Catalasemia em tumor de Wilms
DOI:
https://doi.org/10.32635/2176-9745.RBC.1990v36n1/4.3113Palavras-chave:
Tumor de Wilms, Deficiência de CatalaseResumo
A associação de deficiência de catalase com neoplasias tem sido estudada nos últimos anos, sendo particularmente notável na presença de tumor de Wilms, forma hereditária, e aniridia. Pouco se comenta sobre seu comportamento nas formas esporádicas desse tumor. Em 1984, Turleau e cois. descreveram o primeiro caso de tumor de Wilms e deficiência de catalase, sem aniridia. No presente estudo avaliamos a catalasemia em 13 pacientes com tumor de Wilms e comparamos seus níveis com os de 22 crianças do grupo-controle normal e 10 determinações de um grupo-controle em quimioterapia. Os resultados mostram que a catalasemia foi mais elevada no grupo de pacientes com tumor de Wilms do que no controle normal e mais elevada ainda naqueles que já haviam concluído o tratamento quimioterápico proposto. O grupo-controle em quimioterapia também apresentou níveis elevados de catalasemia, fazendo supor que essa atividade enzimática sofre influência da ação dos quimioterápicos ou, ainda, que ela está associada a uma situação de homeostase do hospedeiro.
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