Hipercalcemias das Neoplasias Malignas

Autores

  • Sonia M. O. Guerra Médica. Serviço de Clínica Médica. Instituto Nacional do Câncer (INCA). Rio de Janeiro (RJ), Brasil.
  • Wlademir Gonzalez Médico. Serviço de Clínica Médica. Instituto Nacional do Câncer (INCA). Rio de Janeiro (RJ), Brasil.
  • Mário Panza Chefe. Serviço de Clínica Médica. Instituto Nacional do Câncer (INCA). Rio de Janeiro (RJ), Brasil.

DOI:

https://doi.org/10.32635/2176-9745.RBC.1982v29n2.3530

Palavras-chave:

Neoplasias/complicações, Hipercalcemia

Resumo

Os autores fazem uma revisão dos mecanismos fisiopatológicos de hipercalcemia em neoplasias malignas, abordando também o quadro clínico e diagnóstico diferencial, assim como as diversas formas de tratamento disponíveis. Um caso clínico é descrito para fins ilustrativos.

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Referências

ALBRIGHT, F. — Cited in case Records of the Massachussets General Hospital; Case 27461. N. Engl. J. Med., 225: 789-791, 1941. DOI: https://doi.org/10.1056/NEJM194111132252007

ALBRIGHT, F.; BAUER, W,; CLAFLIN, O. et al. — Studies in parathyroid physiology III. The effect of phosphate ingestion in clinical hyperparathyroidism. J. Clin. invest., II: 411-435, 1953. DOI: https://doi.org/10.1172/JCI100423

BECKER, V.L., — Hypercalcemia associated with estrogen administration in patients with breast carcinoma. Cancer, 24: 610-616, 1969. DOI: https://doi.org/10.1002/1097-0142(196909)24:3<610::AID-CNCR2820240328>3.0.CO;2-4

BINSTOCK, M.L.; MUNDY, G.R. — Effect of calcitonin and glucocorticoids in combination on the hypercalcemia Of malignancy. Ann. intern. Med., 93: 269-272, 1980. DOI: https://doi.org/10.7326/0003-4819-93-2-269

BRERETON, H.D.; HALUSHKA, P.V.; ALEXANDRE, R.W. et al. - Indomethacin-responsive hypercalcemia in a patient with renal cell adenocarcinoma. N. Engl. J. Med., 291'.83-85, 1974. DOI: https://doi.org/10.1056/NEJM197407112910207

BREWER, H.B. - Osteoclastic Bone Resorption and the hypercalcemia of cancer. N. Engi. J. Med., 291: 1081-1082, 1974. DOI: https://doi.org/10.1056/NEJM197411142912009

DEFTOS, L.J.; FIRST, B.P. - Calcitonin as a drug. Ann Intern. Med., 95: 192-197, 1981. DOI: https://doi.org/10.7326/0003-4819-95-2-192

EILON, G.; MUNDY, G.R.-Direct resorption of bone by human breast câncer cells in vitro. Nature, 276: 726-728, 1978. DOI: https://doi.org/10.1038/276726a0

FAN, H.W., FAHEY, T.J.; NASH, A.G. et al. — Primary hyperparathyroidism and câncer. Am. J. Surg., 126: 539-543, 1973. DOI: https://doi.org/10.1016/S0002-9610(73)80046-7

GOLDSMITH, R.S. - Treatment of hypercalcemia. Med. Clin. of North America, 56: 951 -960, 1972. DOI: https://doi.org/10.1016/S0025-7125(16)32361-6

GOLDSMITH, R.S.; - INGBAR, S. H. — Inorganic Phosphatetreatment of hypercalcemia of diverse etiologies. N. Engi. J. Med., 274: 1-7, 1966. DOI: https://doi.org/10.1056/NEJM196601062740101

HICKEY, R.C.; SAMAAN, N.A.; JACKSON, G.L. — Hypercalcemia in patients with breast cancer. Arch Surg, 116: 545-552, 1981. DOI: https://doi.org/10.1001/archsurg.1981.01380170035006

HIRSHORN, J.E.; VRHOUSEK, E.; POSEN, S. — Carcinoma of the breast associated with hypercalcemia and the presence of parathyrold hormone-like substance in the tumor. J. Clin. Cndocrinol. Metab., 48: 217-221, 1979. DOI: https://doi.org/10.1210/jcem-48-2-217

HORTON, J.E. et al. — Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science, 177: 793-795, 1972. DOI: https://doi.org/10.1126/science.177.4051.793

JACOBS, T.P.; SIRIS, E.S.; BILEZIKIAN, J.P. et al. — Hypercalcemia of malignancy: Treatment with intravenous dichioromethylene diphosphonate. Ann. intern. Med.,94: 312-316, 1981. DOI: https://doi.org/10.7326/0003-4819-94-3-312

KAPLAN, L; KATZ, A.D.; BEN, I.C. et al. — Malignat neoplasms and paratyroid adenoma. Cancer, 28: 401-407,1971. DOI: https://doi.org/10.1002/1097-0142(197108)28:2<401::AID-CNCR2820280221>3.0.CO;2-H

KENNEDY, B.J.; TIBBETS, D.M.; NATHANSON, I.T. et al. - Hypercalcemia, a complication of hormona therapy of advanced breast cancer. Cancer Res., 13: 445, 1953.

LAFFERTY, F.W. — Pseudohyperparathyroidsm. Medicine 45- 247-260, 1966. DOI: https://doi.org/10.1097/00005792-196605000-00004

LENTZ, R.D., BROWN, D.M.; KJELLSTRAND, C.M. – Treatment of Severe hypophosphatemía. Ann. intern. Med., 89: 941 -944, 1978. DOI: https://doi.org/10.7326/0003-4819-89-6-941

LEVINE, L.; HINKLE, P.M.; VOELKEL, E.F. et al. — Prostaglandin production by mouse fibrosarcoma cells in tissue culture: inhibition by indomethacin and aspirín. Bioch. Biophys Res. Commun., 47: 888-896, 1972. DOI: https://doi.org/10.1016/0006-291X(72)90576-1

MAVLIGIT, G.M.; COHEN, J.L.; SHERWOOD, L.M. Ectoplc production of paratyroid hormone and carcinoma of the breast. N. Engl. J. Med., 285: 154-156, 1971. DOI: https://doi.org/10.1056/NEJM197107152850307

MUGGIA, F.M.; HEINEMANN, H. C. - Hypercalcemia associated with Neoplastic Disease. Ann. intern. Med., 73, 2: 281-290, 1970. DOI: https://doi.org/10.7326/0003-4819-73-2-281

MUNDY, G.R.; RAISZ, L.G.; COOPER, R.A. et al. — Evidence for the secretion of an osteoclast stimulating factor in myeloma. N. Engl. J. Med., 291: 1041-1046, 1974. DOI: https://doi.org/10.1056/NEJM197411142912001

POWELL, D.; SINGER, F.R.; MURRAY, T.M. et al.: — Nonparathyroyd humoral hypercalcemia in patients with neoplastic diseases. N. Engl. J. Med. 289: 176-181, 1973. DOI: https://doi.org/10.1056/NEJM197307262890403

RAISZ, L.G. — Prostaglandins and the Hypercalcemia of cancer. N Engl. J. Med., 289: 214-215, 1973. DOI: https://doi.org/10.1056/NEJM197307262890412

RAISZ, L.G.; YAJNIK, C.H.; BOKMAN, R.S. et al. — Comparison of comercially Available Parathyroid Hormone Immunoassays in the differencial diagnosis of hypercalcemia dueto primary hyperparathyroidism or malignancy. Ann. intern. Med., 91: 739-740, 1979. DOI: https://doi.org/10.7326/0003-4819-91-5-739

SCHNEIDER, A.B.; SHERWOOD, L.M. — Calcium homeostasis and the pathogenesis and management of hypercalcemic disorders. Metabolism, 29: 975-1007, 1974. DOI: https://doi.org/10.1016/0026-0495(74)90046-8

SCHOLTZ, D.A.; PURNELL, D.C; GOLDSMITH, R.S. et al. — Diagnostic considerations in hypercalcemic Syndromes. Med. Clin. of North America, 56: 941-950, 1972. DOI: https://doi.org/10.1016/S0025-7125(16)32360-4

SEYBERTH, H.W.; SEGRE, G.V.; MORGAN, J. L. et al. Prostaglandins as mediators of hypercalcemia associated with certain types of cancer. N. Engl. J. Med., 293: 1278-1283, 1975. DOI: https://doi.org/10.1056/NEJM197512182932502

SHERWOOD, L.M. - Ectopic hormone syndromes. In: Ingbar S.M., ed contemporary endocrinology Vol. I New York. Plenum Press, 341-386, 1979. DOI: https://doi.org/10.1007/978-1-4757-4857-4_10

SHERWOOD, L.M. - The Multiple causes of hypercalcemia in malignant disease. N. Engl. J. Med 303: 1412-1413, 1980. DOI: https://doi.org/10.1056/NEJM198012113032409

STEWART, A.F.; HORTS, R.; DEFTOS, L.J. et al. — Biochemical evaluation of patients with cancer — Associated hypercalcemia: Evidence for humoral and nonhumoral groups. N. Engl. J. Med., 303: 1377- 1383, 1980. DOI: https://doi.org/10.1056/NEJM198012113032401

SUKI, W.N.; YIUM, J.J.; VON MINDEN, M. et al. — Acute Treatment of hypercalcemia with furosemida. N. Engl. J. Med., 283: 836-840, 1970. DOI: https://doi.org/10.1056/NEJM197010152831603

TASHJIAN Jr. A. H.; VOELKEL E.F.; GOLDHABER, P. et al. - Successfull treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrossarcoma. Prostaglandins, 3: 515-524, 1973. DOI: https://doi.org/10.1016/0090-6980(73)90161-5

TASHJIAN Jr., A.H. — Tumor Humors and the hypercalcemias of cancer. N. Engl. J. Med., 290: 905-906, 1974. DOI: https://doi.org/10.1056/NEJM197404182901611

TASHJIAN Jr. A. H. — Prostaglandins, hypercalcemia and cancer. N. Engl.. J. Med., 293: 1317-1318, 1975. DOI: https://doi.org/10.1056/NEJM197512182932511

TASHJIAN, Jr., A.H. Role of prostaglandins in the production of hypercalcemia by tumors. Cancer Res.. 38: 4139-4141, 1978.

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Publicado

2023-08-10

Como Citar

1.
Guerra SMO, Gonzalez W, Panza M. Hipercalcemias das Neoplasias Malignas. Rev. Bras. Cancerol. [Internet]. 10º de agosto de 2023 [citado 23º de dezembro de 2024];29(2):5-11. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/3530

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