Ocular Metastasis of Breast Cancer: Five Cases Report

Abstract

The authors report five cases of women with breast cancer with ocular dissemination. Four patients presented systemic disease at the time of diagnosis of ocular metastasis, while one presented it as the first sign of breast cancer, not previously diagnosed. The age of the patients ranged between 36 and 48 years when diagnosis was made. The time period between diagnosis of breast cancer and metastatic disease was from 13 to 132 months. After diagnosis of ocular disease, the survival ranged from 4 to 50 months. The time period between diagnosis of breast cancer and the onset of ocular signs and symptoms ranged from 0 to 128 months, with an average time period of 60 months. Two patients received chemotherapy, while the others received both radiotherapy and chemotherapy. It is important to point out that two patients developed ocular metastasis while being treated with chemotherapy. Although the sensitivity of metastasis to radiotherapy has been well documented in different studies, the effectiveness of chemotherapy has not been well documented in previous studies.