Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages
DOI:
https://doi.org/10.32635/2176-9745.RBC.1998v44n3.2811Keywords:
Cathodic Electrotherapy, Ehrlich Ascitic Tumor, Necrosis Percentage, TumorAbstract
Electrotherapy with direct electric current was performed on a subcutaneous murine tumor model (Ehrlich tumor). The current was supplied through Pt electrodes, where the cathode was inserted directly into the tumors and the anode subcutaneously in their vicinity. After the single shock electrotherapy the tumors volume diminish and the necrosis percentage were observed to be significant and dependent on direct electric current (1.8 and 4 mA). On the repetitive electrotherapy with 1.8 and 4 mA in different days and sites of tumor, tumor volume decrease was also observed. The control groups in both were subjected to the same conditions without electric current. These results show that electrotherapy in advanced stages also can be an effective antitumoral therapy and that its ejfects are better for the highest current intensity. It was concluded that electrotherapy for these stages must be applied by means of an electrodes array placed symmetrically all over the tumor, or in sections ofthe tumor separately, with the aim ofreducing the high voltage applied between the electrodes.
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