Ovary tumor by Sertoli-Leydig cells tumor - A case report and review of the literature
DOI:
https://doi.org/10.32635/2176-9745.RBC.1998v44n4.2832Keywords:
Sertoli-Leydig Cell Tumor, Ovary, ChildAbstract
The authors report a case of a Sertoli-Leydig cell tumor (SLCT), stage Ia, in the right ovary of a 10-year-old girl. The initial clinical manifestations were pain and abdominal distention. A physical examination revealed a large abdominal tumor located in the central region of abdomen. She didn ’t show signs of virilization. Manifestations of precocious puberty were not noticed. Laparotomy was performed, a right salpingo- oophorectomy with incision biopsy of the left ovary was carried out. Histopathologically, it was a well differentiated tumor without heterologous elements. The patient has been free of disease for 34 months, now. We think this case is the first report in the Brazilian medical literature index of SLCT in a child younger than 10 years of age.
Downloads
References
Young, R.H.; Clement, P.B.; Scully, E. – The Ovary. In: Sternberg SS (ed.) Diagnostic Surgical Pathology, 2“ ed, New York, Raven Press Ltda, 2195-2279,1994.
Breen, J.L.; Maxson, W.S. - Ovarian tumors in children and adolescents. Clinicai Obst Gynecol, 20(3): 607-623,1977. DOI: https://doi.org/10.1097/00003081-197709000-00010
Abrão, F.S.; Farias, J.W.M.; Silva, B.B. - Androblastoma do ovário. Rev Paul Med, 97:86-88, 1981.
Kawage, K.; Yoshiro, F. - Androblastoma in a five-year-oldgirl.JPNJClin Oncol, 19:149-152,1989.
Chadha, S.; Honnebier, W.J.; Schabirg, A. - Raised seven a-fetoprotein in Sertoli-Leydig cell tumor (Androblastoma) of ovary: report of two cases. Int J Gynecol Pathol, 6:82-88, 1987. DOI: https://doi.org/10.1097/00004347-198703000-00010
Young, R.H.; Scully, R.E. - Ovarian Sertoli-Leydig cell tumors - a clinico pathological analysis of207 cases. Am J Surg Pathol, 9(8): 543-569,1985. DOI: https://doi.org/10.1097/00000478-198508000-00001
Emembolu, J. - Malignant giant androblastoma of the ovary with masculinization: a case report. Cen Aff J Med, 32(11):277-281, 1996.
Florencio, R.S.; Costa, I.A. - Tumor virilizante do ovário. Rev Bras Ginecol Obstet, 2: 32-34,1989.
Sainzde la Cuesta, R.; Rock, J. A., et al. – Case report - analy sis for steroid production of a Sertoli-Leydig cell tumor. Ginecol Oncol, 52: 276-280,1994. DOI: https://doi.org/10.1006/gyno.1994.1046
Farley, J.H.; Taylor, R.R.; Bossdier, J.R. - Case report: late presentation of an a-feto protein secreting isolated large upper abdominal retroperitoneal Sertoli-Leydig cell tumor recurrence. Gynecol Oncol, 56:319-322, 1995. DOI: https://doi.org/10.1006/gyno.1995.1055
Hammad, A.;Jasnosz, K.M.;Olson,P.R.-Expression of a-fetoprotein by ovarian Sertoli-Leydig cell tumors - case report and review of theliterature. ArchPatholLabMed, 119:1075-1079,1995.
Singh, Z.N.; Suigh, M.K.; Chopra, P. – Sertoli-Leydig cell tumor with malignant heterologous elements and raised alpha-feto-protein; a case report. J Obstet Gynaecol Res, 22(6): 595-8, 1996. DOI: https://doi.org/10.1111/j.1447-0756.1996.tb01076.x
Gershenson, D.M.; Moreis, M.; Burke, T.W.; Levenbock, C.; Matthews, C.M.; Wharton, J.T. - Treatment of poor-prognosis sex cordstromal tumors of the ovary with the combination of Bleomicin, Etoposide and cisplatin. Obstet Gynecol, 87(4); 527-31,1996. DOI: https://doi.org/10.1016/0029-7844(95)00491-2
Flores, O.R. - Tumor de células de Sertoli-Leydig. Rev Med Hond, 59:29-33,1991.
Kasperlik-Zoluska, A.A. (17); Sikorawa, L., et al. - Ectopic Acth syndrome due to bilateral ovarian androblastoma with double, gynandroblastic differentiation in one ovary. EurJObst Gynecol, 52:223-228,1993. DOI: https://doi.org/10.1016/0028-2243(93)90077-P
Ayhan, A.; Tunner, Z.S.; Hakverdian, A.V.; Yuce, K.; Ayhan, A. - Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases. Eur J Gynaecol Oncol, 17(1): 75-8,1996.
Perez, E.; Mena, R.; Diaz, J.R.; Ortiz, FI.; Ramirez, L. A. - Arrenoblastoma. Rev Med Dominicana, 49; 27-28,1988.
Lunde, O.; Djoselandi, O. - Hirsutism caused by an androgen-producing ovarian tumor. A case of arrhenoblastoma. J Endocrinol Invest,9:513-516,1986. DOI: https://doi.org/10.1007/BF03346978
Hales, S.A.; Cree,I.A.; Pinion, S. – A poorly differentiated Sertoli-Leydig cell tumor associated with an ovarian sex cord tumor with annular tubules in a woman with Pints Jeghers syndrome. Histopathology, 25: 391-393,1994. DOI: https://doi.org/10.1111/j.1365-2559.1994.tb01361.x
Sever, I.B.; Pasquiuelli,G.; Martinelli,G.N., et col.- Origin of unreacti ve hyaline bodies from erythrocytis in genital tumors. J Submicroscop Cytol Pathol,26(2);211-217,1994.
Halperin, E.C.; Constine, L.S.; Tarbell, N.J.; Kun, L.E. - Germ and stromal cell tumors of the gonads and extragonadal germ cell tumor. In: Pediatric Radiation Oncology, 2“ ed, New Y ork, Raven Press Ltd, p. 402-414,1994.
Kristensen, G.B.; Baunsgaard, P.; Hessel-dahl, H. - Androblastoma associated with pregnancy in two sisters. Case report. Br J Obst and Gynaecol, 91:592-595,1984. DOI: https://doi.org/10.1111/j.1471-0528.1984.tb04809.x
Munemura, M.;Inoue,S.;Himeno,R.;Koyama, N., et al. - Endocrine studies on ovarian androblastomas. JEndocrinol Invest, 7: 615-621,1984. DOI: https://doi.org/10.1007/BF03349495
Wiebe, R.H.; Morris, C.V. - Testosterona/Androstenedione ratio in the evaluation of women with ovarian androgen excess. Obst Gynecol, 61(3): 279-283,1983.
Ortega, J.; Siegel, SE. - Biologic markers in pediatric solid tumors. In Pizzo PA& Poplac DG (ed) Principies and Practice of Pediatric Oncology, 2ª ed, Philadelphia, JB Lippincott Company, p 179-194, 1993.
Parham, D.M. - Pediatric Neoplasia. Morphology and Biology. Lippincott-Ravem Publishers 1996, cap. 12, pag.389.
Young, R.H.; Scully, R. - Pathology of the Female Genital Tract, cap. 19, pág. 607-58, Springer-Verlong-New York. Inc., 3ª ed., 1996.
Abrahamsson, G.; Dahlgren, E.; Hahlin,M.; Knutson, F.; Norstrõm, A.; Janson P.O. – In vitro production of cyclic AMP and steroids from an ovarian Sertoli-Leydig cell tumor. Acta Obstet Gynecol Scand, 74:310-317,1995. DOI: https://doi.org/10.3109/00016349509024456
Sabatino, E.H.; Garcia, I.M.; Quintero, H.; Gonzáles, J.G. - Sindrome virilizante produzido por arrenoblastoma. Rev. C. Pol. Val, 11:131-139,1985
Barkan, A.; Cassorla, F.; Loriaux, L.; Mars hall, J.C. - Pregnancy in a patient with virilizing arrhenoblastoma. Am J. Obstet Gynecol, 149 (8):909-910,1984. DOI: https://doi.org/10.1016/0002-9378(84)90618-5
