Deficiência aguda de tiamina: Efeitos no crescimento e resposta quimioterápica de um fibro-histiocitoma maligno de rato
DOI:
https://doi.org/10.32635/2176-9745.RBC.1990v36n1/4.3117Keywords:
Thiamine Deficiency, Experimental CancerAbstract
The present investigation has been carried on to study the effects of acute thiamine deficiency on the growth and response to chemotherapy of a malignant fibrohistiocytoma (MFH). Rats were inoculated subcutaneously with a tumoral cell suspension and divided into four groups of 10 animals each: animals fed with a thiamine-free diet (TFD); animals fed with a thiamine-free diet and treated with vincristine sulfate (TFV); animais fed a with control diet (CD); and animais fed with a control diet and treated with vincrístine sulfate (TFD). The animals treated with vincristine sulfate (TFV and CDV) showed a decrease in tumoral volume when compared to untreated animais (TFD and CD). The thiamine-deficient and the treated rats (TFV) showed no difference in tumoral volume when compared to animais receiving control diet and treated withvincristine sulfate (TFD). These data led us to conclude that acute thiamine deficiency per se does not alter MFH growth and does not modify the response of the tumor to chemotherapy with vincristine sulfate.
Downloads
References
FARMER PB. Cancer chemotherapy I: Design and mechanism of action cytotoxic drugs. In: Farmer PB, and Walker JM (Editors), The molecular basis of cancer. Croom Heim, London and Sydney 1985: 259-286. DOI: https://doi.org/10.1007/978-1-4684-7313-1_10
VINCENT MD. The clinical problem: In Farmer PB and Walker JM. (Editors). The Molecular Basis of Cancer. Croom Helm, London and Sydney, 1985: 1-236.
BRISTRIAN RR, BLACKBURN GL, VITLATLE J, COCHRAN D, NAYLOR J. Prevalence of malnutrition in general medical patients. Journal American Medical Association 1976; 235: 1567-1570. DOI: https://doi.org/10.1001/jama.235.15.1567
WEINSIER RL, HUNKER EM, KRUNDIECK CL, RUTTERWORD CE. A prospective evaluation of general medical patients during the course of hospitalization. American Journal of Clinical Nutrition, 1979; 32: 418-426. DOI: https://doi.org/10.1093/ajcn/32.2.418
LEEVY CM, CARDI L, FRANK O, GELLENE R, BECKER H. Incidence and significance of hypovitaminemia in a randomly selected municipal hospital population. American Journal of Clinical Nutrition 1965; 17: 259-271. DOI: https://doi.org/10.1093/ajcn/17.4.259
CIPRIANO TC, ZUCOLOTO S, MUCCILLO G. Acute thiamin deficiency: a morphometric and cell proliferation study of jejunum epithelial cell. International Journal for Vitamin and Nutrition Research 1987: 151-154.
KOVACEVIC Z AND McGlVAN JD. Mitochondrial metabolism of glutamine and glutamate and its physiological significance. Physiological Reviews 1983; 63: 547-605. DOI: https://doi.org/10.1152/physrev.1983.63.2.547
THOMLINSON RH, GRAY LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. British Journal of Cancer 1955; 9: 539-549. DOI: https://doi.org/10.1038/bjc.1955.55
GOLDACRE RJ, SYLVEN B. On the accessofblood-borne dyes to various tumor regions. British Journal of Cancer 1962; 16: 306-322. DOI: https://doi.org/10.1038/bjc.1962.36
GULLENO PM. The internal milieu of tumors. Progress of Experimental Tumor Research 1966; 8: 1-25. DOI: https://doi.org/10.1159/000386002
TANNOCK IF. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumor. British Journal of Cancer 1968; 22: 258-273. DOI: https://doi.org/10.1038/bjc.1968.34
RIBEIRO RA, BEZERRA DE ARAÚJO RW, FONTELES MC, FERREIRA FVA, ZUCOLOTO S, ROSSI MA. Tumor fibrohistiocltico (TEGS-2047) transplantável em ratos Wistar - Histopatologia, ultra-estrutura, citoquímica enzimática e potencial metastático. Rev Bras Cancerol 1986a; 32(2): 159.
RIBEIRO RA, ZUCOLOTO S, CIPRIANO TC, LEITÃO MC, FONTELES MC. Tumor fibro-histiocítico (TEGS-2047) transplantável em ratos Wistar - Estudo cinético com bloqueador de mitose. Rev Bras Cancerol 1986b; 32(2): 160.
RIBEIRO RA, FONTELES MC, ZUCOLOTO S, BACCHI CE. lmunohistochemical identification of lysozyme and Vimentin in na experimental malignant fibrous histiocytoma. Brazilian J Med Biol Aos 1988; 21: 995-997.
HENDERSON GI, DILLON M, SCHENKER S. Effect of diet-induced thiamine deficiency on visceral DNA synthesis and tissue composition. Biochem Pharmacol 1976; 25: 2275-2284. DOI: https://doi.org/10.1016/0006-2952(76)90010-1
PAUL F. CeIl on tissue culture. Churchill Livingstone, New York 1975; 219-231.
STEEL GG. Growth kinetics of tumors. Clarendon Press, Oxford 1977: 5-55.
FÉAUX DE LACROIX W, WEYER M, SCHULT A, LENNARTZ KJ. Age-dependent change of the effect of a cytostatic during on the proliferation kinetics of a solid tumours of the mouse. Journal Cancer Research Clinical Oncology 1979; 94: 29-35. DOI: https://doi.org/10.1007/BF00405347
ARAÚJO RWB, ZUCOLOTO S, FERREIRA FVA, CIPRIANO TC, MELLO DE OLIVEIRA, ROSSI MA CONACCHIONI ALB. Estrutura, perfil histoquímico e comportamento biológico de tumor espontâneo da região da glândula salivar de rato (TEGS-2047). Anais do XVI Congresso Brasileiro de Patologia, 1985; pág. 131.
PEDERSON PL. Tumor mitochondrial and the bioenergetics of cancer cells. Progress Experimental Tumor Research 1978; 22: 190-274. DOI: https://doi.org/10.1159/000401202
RIVERA S, LÓPEZ-SORRANO FJ, AZCON-BIETS J, ARGILES JM. Blood amino acid compartmentation in mico bearing lewis lung carcinoma. Cancer Research 1987; 47: 5644-5646.
CURRIE G, CURRIE A. Cancer the biology of malignant disease. Castlefield Press. Northhampton, England 1982; pp. 39.
CLARCK CM, GOODLAD GAC. Depletion of protein of phasic and tonic muscle in tumor bearing rata. European Cancer 1971; 7:3-9. DOI: https://doi.org/10.1016/0014-2964(71)90088-0
KOVACEVIC Z. Properties and intracellular localizations of Ehrlich ascites tumor cells glutamirrase. Cancer Research 1974: 34: 3403-3407.
LAZO PA. Tumor induction of host leucine starvatiori. FEBS Letters, 1981; 229-231. DOI: https://doi.org/10.1016/0014-5793(81)80788-0
CARRASCOSA JM, MARTINS P AND NUIJEZ DE CASTRO I. Mtrogen movement between host and tumor in mice inoculated with Ehrlich ascitic tumor celis. Cancer Research 1984; 44: 3831-3835.
HAYES KC. Taurine in metabolism. Annual Review of Nutrition 1986; 1:401-425. DOI: https://doi.org/10.1146/annurev.nu.01.070181.002153
LAVIETES BB, REGAN DH, DEMOPOULOS HB. Glutamate oxidation in 6C31-1ED Iymphoma: Effects of L-asparaginase on sensitive and resistant lines. Proceedings National Academy of Sciences 1974; 71: 3993-3997. DOI: https://doi.org/10.1073/pnas.71.10.3993
REITZER LJ, WICE BM AND KENNELL D. Evidence that glutamine, not sugar is the major energy source for cultured HeLa cells. Journal of Biological Chemistry 1979; 254: 2669-2676. DOI: https://doi.org/10.1016/S0021-9258(17)30124-2
CAMPLEJOHN RS, SCHULTZE B, MAVRER W. An in vivo double Iabelling study of the subsequent fate of celis arrested in metáfase by vincristine in the J .B. 1 mouse ascites tumor. CeUs Tissue Kinetic 1980; 13: 239-245. DOI: https://doi.org/10.1111/j.1365-2184.1980.tb00463.x
FÉAUX DE LACROIX W, MALLMAN H. Comparative investigatioris on the effect of different dose schedules of the phase-specific during vincristine (VCR) on the proliferation kinetics of a solid experimental tumour. Cell Tissue Kinetic 1984: 583-591. DOI: https://doi.org/10.1111/j.1365-2184.1984.tb00617.x
OWELLEN RJ, OWENS AH JR., DONIGIAN DW. The bindings of vincristine, vinblastine and coichicirre to tubulin. Biochemical and Biophysical Research Community 1972; 47: 685-691. DOI: https://doi.org/10.1016/0006-291X(72)90546-3
OWELLEN RJ, HARTKE CA, DICKERSON RM, HAINS FO. Inhibition of tubulin-microtubule polymenzation by drugs of the vinca alkaloid class. Cancer Research 1976; 36: 1499-1502.
CREASEY WA. Modifications in biochemical patways produced by the vinca alkaloids. Cancer Chemotherapic 1968; 52: 501-507.
WAGNER EK, ROIZMAN B. Effects of the vinca alkaloids on ANA synthesis in human in vivo. Science 1968; 162: 569-570. DOI: https://doi.org/10.1126/science.162.3853.569
RICHARDS JF. Biochemical studies with the vinca alkaloids. Cancer Chemotherapic Report 1968; 52: 463-467.
Howards SMH, Theologides A and Sheppard JR. Comparative effects of vindesine, vinblastina and vincristine on mitotic arrest and hormonal response of L1210 Ieukemia cells. Cancer Research 1980; 40: 2695-2700.
SEPPARD JA. Effects of vinca alkaloids on cyclic AMP metabolismo of mouse splenic lymphocytes. Contribution of Oncology 1980; 6: 27-36. DOI: https://doi.org/10.1159/000428614
BECK WT. Increase by vinblastine of oxidized glutathiorre in cultured mammalian celis. Biochemistry Pharmacology 1980; 29: 2333-2337. DOI: https://doi.org/10.1016/0006-2952(80)90266-X
GIETZAN K, WUTRICH A, BODER H. Effects of microtubular inhibitors on plasma membrane calmodullin-dependent CA2-transport ATPase. Molecular Pharmacology 1982; 22: 413-420.
