Deficiência aguda de tiamina: Efeitos no crescimento e resposta quimioterápica de um fibro-histiocitoma maligno de rato
DOI:
https://doi.org/10.32635/2176-9745.RBC.1990v36n1/4.3117Palavras-chave:
Deficiência Aguda em Tiamina, Fibro-Histiocitoma Maligno, QuimioterapiaResumo
Os objetivos do presente trabalho foram estudar os efeitos da deficiência aguda de tiamina no crescimento e na resposta quimioterápica de um fibro-histiocitoma maligno no rato. Para tanto, ratos foram inoculados por via subcutânea com suspensão de células tumorais e divididos em quatro grupos, de 10 animais cada: DCT - alimentados com dieta sem tiamina; DVC - alimentados com dieta sem tiamina e tratados com sulfato de vincristina (SVC); TGT - Alimentados com dieta-controle; e TVC - alimentados com dieta-controle e tratados com SVC. Os animais tratados com SVC (DVC e TVC) apresentaram diminuição de volume tumoral quando comparados com os não tratados (DCT e TCT). Entretanto, não houve alteração no volume tumoral de animais carentes em tiamina e tratados (DVC) em relação àqueles tratados e com dieta-controle (DCT). Estes dados indicam que a deficiência aguda de tiamina per se não altera o crescimento do FHM como também não modifica a resposta do tumor frente à quimioterapia com SVC.
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