Marcadores Biológicos Potenciais na Avaliação do Câncer da Mama
DOI:
https://doi.org/10.32635/2176-9745.RBC.1982v29n2.3540Keywords:
Breast Neoplasms/diagnosis, Receptors, Cell Surface, Receptors, EstrogenAbstract
There are large numbers of tumor-associated markers that can be immunologically detected and are under active evaluation for their applicability in the diagnosis and management of cancer. The principal agents used for human breast cancer are steroid hormone receptor and surface antigens specifically associated with tumor cells. To predict hormone dependency with accuracy, the analysis of Estradiol and Progesterone receptors (Es, PgR) is suggested. The authors stress the need of well Studied Standard Carcinoembrionic Antigen (CEA) levels as monitoring tools to evaluate the results of therapy.
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ALLEGRA, J.C.; BARLOCK, A.; HUFF, K.K.; LIPPMAN, M.E. - Changes in multiple or sequential ER determinations in breast cancer. Cancer, 45: 792-794, 1980. DOI: https://doi.org/10.1002/1097-0142(19800215)45:4<792::AID-CNCR2820450430>3.0.CO;2-X
ANTONIADES, K.; SPECTOR, H.— Correlation of Estrogen Receptor levels with histology and cytomorphology in human mammary cancer. Am. J. Clin. Pathol., 71: 497-503, 1979. DOI: https://doi.org/10.1093/ajcp/71.5.497
BEATSON, G.T. - Oh the treatment of inoperable cases of carcinoma of the mamma. Suggestions for a new method of treatment, with illustrative cases: Lancet, 2: 104-107, 1896. DOI: https://doi.org/10.1016/S0140-6736(01)72307-0
BEATTY, J.D.; ROMERO, C.; BROWN, P.W.: LAWRENCE Jr., W.; TERZ, J.J. — Clinical value of Carcinoembryonic Antigen. Diagnosis, prognosis, and follow-up of patients with cancer. Arch Surg., 114: 563-567, 1979. DOI: https://doi.org/10.1001/archsurg.1979.01370290013002
BURKE, R.E.; MIRA, J.G.; DATTA, R; ZAVA, D.T.; McGUIRE, W.L. - Estrogen action following irradiation of human breast cancer cells. Cancer Res., 38: 2813-2817, 1978.
COOMBES, R.C.; POWLES, T.J.- GAZET, J.C.; NASH, A.G.; FORD, H.T.; McKINNA, A; NEVILLE, A.M. — Assessment of biochemical tests to screen for metastases in patients with breast cancef. Lancet, 9, 8163: 296-291, 1980. DOI: https://doi.org/10.1016/S0140-6736(80)90790-4
COOPER, A.P.: — In: The principles and practice of surgery. Vol. I. ed. London, E. Cox: 333-335; 1836 (Citado por Jensen E.V. in: Cancer 46 (suppl.): 2759-2761,1980). DOI: https://doi.org/10.1002/1097-0142(19801215)46:12+<2759::AID-CNCR2820461402>3.0.CO;2-7
De SOMBRE, E.R.; GREENE, G.L. JENSEN, E.V. — Estrophilin and endocrine responsiveness of breast cancer. In: Hormones, Receptors and Breast Cancer. Raven Press, NY ed. Mc Guire: 1-14, 1978.
FALKSON, H.C.;VAN DER WATT, J.J.; PORTUGAL, M.A. PITOUT. M.S.; FALKSON, G. Carcinoembryonic Antigen in patients with breast cancer. An adjuntive tool to monitor response and therapy. Cancer, 42: 1308, 1313, 1978. DOI: https://doi.org/10.1002/1097-0142(197809)42:3<1308::AID-CNCR2820420341>3.0.CO;2-N
FRANCHIMONT, P.; ZANGERLE P.F.; NOGAREDE, J.; BURY F MOLTER, F.; REUTER, A.; HENDRICK.S.C.; COLLETTE, J. -Simultaneous assays of cancer - associated antigens in various neoplastic disorders. Cancer, 88: 2287-2295, 1976. DOI: https://doi.org/10.1002/1097-0142(197612)38:6<2287::AID-CNCR2820380616>3.0.CO;2-2
GOLD, P.; FREEDMAN, S.O. - Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med., 121: 439-459, 1965. DOI: https://doi.org/10.1084/jem.121.3.439
GRODIN, J.M.; SÜTERI, P.K.; Mac DONALD, P.C. — Surce of Estrogen production in postmenopausal women J. Clin. Endocrinot. Metab., 36: 207-214, 1973. DOI: https://doi.org/10.1210/jcem-36-2-207
HAAGENSEN Jr., D.E.; KISTER, S.J.; VANDEVOORDE, J.P.; GATES, J.B.; SMART, E.K.; HANSEN, H.J.; WELLS J.r., S.A. — Evaluation of CEA as a plasma monitor for human breast carcinoma. Cancer, 42: (SuppI.): 1512-1 519, 1978. DOI: https://doi.org/10.1002/1097-0142(197809)42:3+<1512::AID-CNCR2820420824>3.0.CO;2-6
HAHNEL, R.; WOODINGS, T.; VIVIAN, A.B. — Prognostic value of Estrogen Receptors in primary breast cancer. Cancer, 44: 671 -675, 1979. DOI: https://doi.org/10.1002/1097-0142(197908)44:2<671::AID-CNCR2820440238>3.0.CO;2-V
HANSEN, H.J.; SNYDER, J.J.; MILLER, E.; VANDEVOORDE, J.P.; MILLER, O.N.; HINES, L.R.; BURNS, J.J. — Carcinoembryonic Antigen assay. A laboratory adjunct in the diagnosis and management of cancer. Human Pathol., 5: 139-147, 1974. DOI: https://doi.org/10.1016/S0046-8177(74)80061-4
HEUSON, J.C.; LONGEVAL, E.; MATTHEIEM, W.H.; DEBOEL, M. C.; SYLVESTER, R.J.; LECLERCQ. G. — Significance of quantitative assessment of ER for endocrine therapy in advanced breast cancer. Cancer, 39: 1971-1977; 1977. DOI: https://doi.org/10.1002/1097-0142(197705)39:5<1971::AID-CNCR2820390510>3.0.CO;2-8
HEUSON, J.C.; LECLERCQ, G.; LONGEVAL, E.; DEBOEL, M.C.- MATTHEIEM, W.H.; HEIMANN, R. — Estrogen Receptors: Prognostic significance in breast cancer. In: Estrogen receptors in human breast cancer. Raven Press, N.Y., ed. W.L. McGuire: 57-72, 1975.
HUGGINS, C.; BERGENSTAL, D. M. — Inibition of human mammary and prostatlc cancers by adrenalectomy. Cancer Res., 12: 134-141, 1952.
JENSEN, E.V. — Estrogen Receptors in hormone-dependent breast cancers. Cancer Res., 35: 3362-3364, 1975.
KNIGHT, W.A.; LIVINGSTON, R. B.; GREGORY, E.J.; McGUIRE, W.L. — Estrogen Receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res., 37: 4669-4771, 1977.
LECLERCQ, G.; HEUSON, J.C.; DE BOEL. M.C.; LEGROS. N.: LONGEVAL, E.; MATTHEIM.W.H. - Estrogen and Progesterone Receptors in human breast cancer. In: Progesterone Receptors in normal and neoplastic tissues. Raven Press, N.Y. ed. W.L. McGuire: 141-153, 1977.
LEE, S.H. Cytochemical study of Estrogen Receptor in human mammary cancer. Amer. J. Clin. Pathol. 70: 197-203, 1978. DOI: https://doi.org/10.1093/ajcp/70.2.197
LIPPMAN, M.E.; ALLEGRA, J.C.- THOMPSON, E.B.; SIMON, R.- BARLOCK, A.; GREEN, L; HUFF, K. K.; DO, H.M.T.; AITKEN, S.C.; WARREN, R. — The relation between Estrogen Receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N. Engl. J. Med., 298: 1223-1228, 1978. DOI: https://doi.org/10.1056/NEJM197806012982203
Lo GERFO, P.; KRUPEY, J.; HANSEN, H.J. — Demonstration of anantigen common to several varieties of neoplasia. N. England. J. Med.; 285: 138-141, 1971. DOI: https://doi.org/10.1056/NEJM197107152850302
LOKICH, J.J.; ZAMCHECK, N.; LOWNSTEIN, M.W. – Sequential Carcinoembryonic Antigen levels in the therapy of metastatic breast cancer. A predictor and monitor of response and relepse. Ann. Intern. Med., 89: 902-906, 1978. DOI: https://doi.org/10.7326/0003-4819-89-6-902
LUFT, R.; OLIVECRONA, H. - Experiences with hypophysectomy in man. J. Neurosurg., 10: 301-316, 1953. DOI: https://doi.org/10.3171/jns.1953.10.3.0301
Mac SWEEN.J.M.; WARNER, N.L.; BANKHURST, A.D.; Mac KAY, I. R. — Carcinoembryonic Antigen in whole serum. Br. J. Cancer, 26: 356-360, 1972. DOI: https://doi.org/10.1038/bjc.1972.46
MARTIN. Jr., E.W.; KIBBEY, W.E.; Di VECCHIA, I.; ANDERSON, G.; CATALANO, P.; MENTON, J.P. - Carcinoembryonic Antigen Clinical and historical aspects. Cancer, 37: 62-81, 1976. DOI: https://doi.org/10.1002/1097-0142(197601)37:1<62::AID-CNCR2820370110>3.0.CO;2-#
Mc CARTY, Jr. K.; BARTON, T.K.; FETTER, B.F.; WOODARD, B.H.; MOSSLER, J.A.; REEVS, W.; DALY, J.; WILKINSON, W.E.; Mc CARTY, K.S. - Correlation of Estrogen and Progesterone Receptors with histologic differentiation in mammary carcinoma. Cancer, 46: 2851-2858, 1980. DOI: https://doi.org/10.1002/1097-0142(19801215)46:12+<2851::AID-CNCR2820461424>3.0.CO;2-K
Mc GUIRE, W.L. — Estrogen Receptors in human breast cancer. J. Clin. Invest, 52: 73-77, 1973. DOI: https://doi.org/10.1172/JCI107175
McGUIRE, W.; HORWITZ, K.B.- Progesterone Receptors in breast cancer In: Hormones, Receptors, and Breast cancer. Raven Press, N. Y., ed. Mc Guire: 31-42, 1978. DOI: https://doi.org/10.1016/B978-0-12-526302-3.50019-8
MERCER, W.; WAHL, T.; CARLSON, C.; TEAGUE, P. - Identification of Estrogen and Progesterone Receptors in breast cancer cells by immunological techniques. Feder. Proced., 38: (3 part II): 913,1979.
MlULS, R.R. — Correlation of hormone Receptors with pathological features in human breast cancer. Cancer, 46: 2869-2871, 1980. DOI: https://doi.org/10.1002/1097-0142(19801215)46:12+<2869::AID-CNCR2820461426>3.0.CO;2-Q
PEARSON, O.H.; RAY, B.S.; HARROLD, C.C. et al. — Hypophysectomy in treatment of advanced cancer. J. Am. Med. Assoc., 161: 17-21, 1956. DOI: https://doi.org/10.1001/jama.1956.02970010019005
POMPECKI, R.; SCHROEDER, G.; GARBRECHT, M.; FRAHM, H. - Carcinoembryonic Antigen (CEA) in patients with metastatic breast cancer. Under endocrine therapeutic treatment. Dtsch. Med. Wochenschr, 103: 620-622, 1978. DOI: https://doi.org/10.1055/s-0028-1104486
ROSEN, P.P.; MENENDES-BOTET, C.J.; SENIE, R.T.; SCHWARTZ, M. K.; SCHOTTENFELD, D.; FARR, G.H. — Estrogen Receptor Protein (ERP) and the histopathology of human mammary carcinoma. In: Hormones, Receptors and Breast cancer. Raven Press, N.Y.; ed. Mc Guire: 71-83, 1978.
ROSEN. P.P.; MENENDES-BOTET, C.J.; URBAN, J.A.; FRACCHIA. A.; SCHWARTZ, M.K. - Estrogen Receptor Protein (ERP) in multiple tumor specimens from individual patients with breast cancer. Cancer, 39: 2194-2200, 1977. DOI: https://doi.org/10.1002/1097-0142(197705)39:5<2194::AID-CNCR2820390537>3.0.CO;2-Y
RUBENS, R.D.; KING, R.B. - Oestrogen receptors and response to cytotoxic chemotherapy. Proceedings of Amer. Assoe, for Cancer Res., 20: 304, 1979.
SAEZ, S.; MAYER, M. – Facteurs hormonaux de prévision d'harmonodépendance du câncer di sein. Bull. du Câncer, 64: 557-565, 1977.
SAMAAN, N.A.; BUZDAR, A.U.; ALDINGER, K.A.; SCHULTZ, P.N.; YANG, K.P.; - ROMSDAHL M.M.; MARTIN, R. — Estrogen Receptor: A prognostic factor in breast cancer. Cancer, 47: 554-560, 1981. DOI: https://doi.org/10.1002/1097-0142(19810201)47:3<554::AID-CNCR2820470322>3.0.CO;2-W
STEWARD, A.M.; NIXON, D.W.; ZAMCHECK, N.; AISENBERG, A. — Carcinoembryonic Antigens in breast cancer patients serum levels and disease progress. Cancer, 33: 1246-1252, 1974. DOI: https://doi.org/10.1002/1097-0142(197405)33:5<1246::AID-CNCR2820330509>3.0.CO;2-O
THOMPSON, D.M.P.; KRUPEY, J.; FREEDMAN, S.O.; GOLO, P. – The radioimunoassay of circulating Carcinoembryonic Antigen of the human digestive System. Proc. Natl. Acad. Sci. USA, 64: 161-167, 1969. DOI: https://doi.org/10.1073/pnas.64.1.161
TORMEY, D.C.; WALLKES, T.P. — Clinical correlation between CEA and breast cancer. Cancer, 42 (Suppl): 1507-1 511, 1978. DOI: https://doi.org/10.1002/1097-0142(197809)42:3+<1507::AID-CNCR2820420823>3.0.CO;2-W
TORMEY, D.C;; WAALKES, T.P.; SNYDER, J.J.; SIMON, R.M. - Biological markers in breast carcinomas (III Clinical correlation with Carcinoembryonic Antigens). Cancer, 39: 2397-2404, 1977. DOI: https://doi.org/10.1002/1097-0142(197706)39:6<2397::AID-CNCR2820390614>3.0.CO;2-N
VIDER, M.; KASHMIRI, R.; HUNTER, L. et al. — Carcinoembryonic Antigen (CEA) monitoring in management of radiotherapeutic patients. Oncology (Basel) 30. 257-272, 1974. DOI: https://doi.org/10.1159/000224965
WAHREN, B.; LIDBRINK, E.; WALLGREN, A.; ENEROTH, P.; ZAJFCEK, J. — Carcinoembryonic Antigen and other tumor markers in tissue and serum or plasma of patients with primary mammary carcinoma. Cancer, 42: 1870-1878, 1978. DOI: https://doi.org/10.1002/1097-0142(197810)42:4<1870::AID-CNCR2820420426>3.0.CO;2-Y
WALT, A.J.; SINGHAKOWITA, A.; BROOKS, S.C.; CORTEZ, A. - The surgical implications of estrophile protein estimations in carcinoma of the breast. Surgery, 80: 506-512, 1976.
WANG, D.Y.; BULBROOK, R.D.; HAYWARD, J.L. et al. - Relationship between plasma Carcinoembryonic Antigen and prognosis in women with breast cancer. Eur. J. Cancer, 11: 615-618, 1975. DOI: https://doi.org/10.1016/0014-2964(75)90094-8
WITTLIFF, J.L. - Specific Receptors of the Steroid Hormones in breast cancer. Semin. OncoL, 1: 109-118, 1974.
WITTLIFF, J.L.; HILF, R.; BROOKS Jr., W.F.; SAVLOV, E.O.; HALL, T.C.; ORLANDO, R.A. - Specific Estrogen-binding capacity of the cytoplasmic Receptor in normal and neoplastic breast tissues of humans. Cancer Res., 32: 1983-1992, 1972.