Ação do VM-26 em Casos de Doença de Hodgkin Estádios III e IV
DOI:
https://doi.org/10.32635/2176-9745.RBC.1976v26n5.3811Keywords:
Hodgkin Disease/therapy, Teniposide/therapeutic use, Teniposide/toxicityAbstract
The authors studied the Efficiency of a new podophyllotoxin derivative, in 10 patients with Hodgkin's disease stage III and IV. They obtained 60% of objective responses but no one case of complete remission. Appart from 2 cases of alopecia of median intensity, there were not any side effects with the treatment employed. The authors also found that the doses given were low, proposing further studies with higher doses and new schemes, including the association of VM-26 to other drugs for a better use of the potenciality of this new compound. Finally they concluded that VM-26 could be part of the antiblastic therapeutic arsenal considering its efficiency and its capacity of transposing the hematoencefalic barrier.
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