Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate

Authors

  • Wagner Brant Moreira Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Eduardo Carvalho Brandão Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Eduardo Nascimento Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Eugënio Baumgratz Lopes Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • João Augusto Moreira Teixeira Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Maria do Carmo Lima A. Vieira Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Maria Nunes Álvares Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Rogërio Agenor Araújo Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil
  • Sebastião Cabral Filho Serviço de Oncologia Clínica da Santa Casa de Misericórdia e Centro de Quimioterapia Antiblástica do Hospital Belo Horizonte. Belo horizonte (MG), Brasil

DOI:

https://doi.org/10.32635/2176-9745.RBC.1987v33n2.3197

Keywords:

Burkitt Lymphoma, Chemotherapy

Abstract

Between march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients.

Downloads

Download data is not yet available.

References

Anasssie R, Geha S, Alian C, JabbourJ, Khalyl M, Saiem P - Burkitt's Lymphoma lo the Middle East: A study of 34 cases. Cancer, 1954; 56: 2539-43. DOI: https://doi.org/10.1002/1097-0142(19851115)56:10<2539::AID-CNCR2820561038>3.0.CO;2-5

Appelbaum FR eta! - Prolonged complete remission following high dose chemotherapy of Burkitt's Lymphoma in relapse. Cancer, 1978, 41: 1059-63 DOI: https://doi.org/10.1002/1097-0142(197803)41:3<1059::AID-CNCR2820410339>3.0.CO;2-N

Burkitt DP – The Discovery of Burkstt's Lymphoma, Cancer, 1983,51 1777-86 DOI: https://doi.org/10.1002/1097-0142(19830515)51:10<1777::AID-CNCR2820511003>3.0.CO;2-E

Gasparini Metal - Childhood Non-Hodgkin's Lymphoma: Long-term results of ao intensive chemotherapy regimen. Cancer, 19.81, 48 1508-12. DOI: https://doi.org/10.1002/1097-0142(19811001)48:7<1508::AID-CNCR2820480704>3.0.CO;2-F

Levine AM et aI. - Small noncleaved follscular cen ter cell (FOC) L ymphoma. Burkitt and non-Burkitt variants in the Unsted States. Cancer, 1983; 52 1073-79. DOI: https://doi.org/10.1002/1097-0142(19830915)52:6<1073::AID-CNCR2820520624>3.0.CO;2-F

Levine PH et al. - The American Burkstl's Lymphomas registry Eight year's expertence Cancer, 1982, 49. 1016-22. DOI: https://doi.org/10.1002/1097-0142(19820301)49:5<1016::AID-CNCR2820490527>3.0.CO;2-H

Magrath l et al. - Prognostic factors in Burkitt's Lymphoma. Imporlance of total tumor burden. Cancer, 1980; 45: 1507.15 DOI: https://doi.org/10.1002/1097-0142(19800315)45:6<1507::AID-CNCR2820450634>3.0.CO;2-D

Magrath IT et al. - An effective therapy for both unidifferenciated (including Burkitt's) Lymphoma and Lymphoblastsc Lymphomas in children and Young adults 8100d, 7984, 63. 1102 11 DOI: https://doi.org/10.1182/blood.V63.5.1102.1102

Miliauskas JR et al - Undifferencialed Non-Hodgksn's Lymphoma (Burkitt's and Non-Burkitt's lypes) The relevance of making thss hsstologsc dsstsnct,on. Cancer, 1982; 50:2115-21. DOI: https://doi.org/10.1002/1097-0142(19821115)50:10<2115::AID-CNCR2820501024>3.0.CO;2-9

Nkrumah FK, Perkins CV, Hyg Ms, Bsggar RJ - Combina bois Chemolherapy in abdominal Burkill's Lymphoma. Cancer, 1977; 40 14 10-16. DOI: https://doi.org/10.1002/1097-0142(197710)40:4<1410::AID-CNCR2820400408>3.0.CO;2-M

Nkrumah FK, Neequaye JE, Bsggar 8 - Intratecal Chemotherapy-laxss in lhe prevention of central nervous system relapse in Burkitt's Lymphoma. Cancer, 1985, 56 239-42. DOI: https://doi.org/10.1002/1097-0142(19850715)56:2<239::AID-CNCR2820560205>3.0.CO;2-F

Sullivan MP, Ramirez 1 - Curability of Burkitt's Lymphoma with hsgh-dose Ciclophosphamide high-dose Melhotrexate therapy and intralhecal chemoprophy-laxis J Clin Oncol, 1985; 3 627-36 DOI: https://doi.org/10.1200/JCO.1985.3.5.627

Ziegler JL - Treatmentresults of 54 American patients with Burkitl's Lymphoma are similar to the African experience N Engl J Med, 1977, 297 75-80. DOI: https://doi.org/10.1056/NEJM197707142970202

ZieglerJL - Management of Burki lIs Lymphoma. ao updale Cancer Treal Rev, 1979, 6: 95-105. DOI: https://doi.org/10.1016/S0305-7372(79)80044-4

Ziegler JL - Burkitt's Lymphoma .8 Engl J Med, 1981; 305 735-45 DOI: https://doi.org/10.1056/NEJM198109243051305

Published

2023-08-04

How to Cite

1.
Moreira WB, Brandão EC, Nascimento E, Lopes EB, Teixeira JAM, Vieira M do CLA, Álvares MN, Araújo RA, Cabral Filho S. Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate. Rev. Bras. Cancerol. [Internet]. 2023 Aug. 4 [cited 2024 May 16];33(2):133-9. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/3197

Issue

Section

ORIGINAL ARTICLE

Most read articles by the same author(s)