Evaluation of ASC/SIL Ratio Utility as a Cytopathology Quality Marker

Abstract

Introduction: The term “atypical squamous cells” (ASC) is considered the most frequently epithelial abnormality described in cervical smears, and it’s related to an uncertainty epidemiological group. The ASC/SIL (squamous intraepithelial lesion) ratio has been used by many cytopathology laboratories as a quality marker. Objective: To evaluate the annual ASC/SIL ratio in a large Surgical Pathology Laboratory for a period of 10 years, comparing these data to the values recommended by the College of American Pathologists (CAP), and to verify the utility of the ASC/SIL ratio as a quality marker tool in the ASC cytological interpretation for any cytopathology laboratory. Method: Retrospective and transversal study (2002 to 2011) conducted according to the anatomic pathology laboratory database, located in Joinville/SC. Both conventional cytology and liquid based cytology were included in this study. We established the ASC/SIL ratio per year and the results were compared to the ones published by CAP. Results: The ASC/SIL ratios were the same as those recommended by CAP, with an average of 1.467. Conclusion: The ASC/SIL ratio provides a simple and effective feedback to laboratories about the ASC diagnosis, indicating the need to reduce or elevate this ratio whenever necessary.