Tumor germinativo extra-gonadal e síndrome de Klinefelter - Relato de caso
DOI:
https://doi.org/10.32635/2176-9745.RBC.1996v42n4.2904Palabras clave:
Tumor Germinativo Extragonadal, Síndrome De KlinefelterResumen
Muitos relatos vêm sugerindo a associação entre a síndrome de Klinefelter e o tumor germinativo. Um risco elevado de tumor germinativo extragonadal (mediastinal) ocorre a partir da adolescência até 30 anos. O autor apresenta ocaso de um jovem de 19 anos de idade com sintomas respiratórios, massa torácica e características clínicas de síndrome de Klinefelter. O cariótipo do sangue periférico foi de 47 XXY e o estudo da lesão torácica foi de teratoma imaturo O paciente foi tratado com quimioterapia combinada seguida de toracotomia, estando em remissão completa há seis anos após o diagnóstico. Este estudo discute as características clínicas e laboratoriais dos pacientes com tumor germinativo 235 extragonadal associado a síndrome de Klinefelter, e sua participação na gênese dos tumores de células germinativas.
Descargas
Citas
Lee, MW.; Stephens, R.L. - Klinefelter's syndrome and extragonadal germ cell tumors. Cancer, 60: 1053-1055, 1987. DOI: https://doi.org/10.1002/1097-0142(19870901)60:5<1053::AID-CNCR2820600520>3.0.CO;2-1
Arens, R.; Marcus, D.; Engelberg, S., et al. - Cerebral germinoma and Klinefelter's syndrome. Cancer, 61: 1228-1231, 1988. DOI: https://doi.org/10.1002/1097-0142(19880315)61:6<1228::AID-CNCR2820610628>3.0.CO;2-R
Logothestis - Chemoterapy of extragonadal germ cell tumours. Journal of Clinical Oncology, 3: 316, 1985. DOI: https://doi.org/10.1200/JCO.1985.3.3.316
McNeil, M.M.; Leong, A.S.Y.; SaGe, R.E. - Mediastinal embryonal cancer in Klinefelter's syndrome. Cancer, 47: 343-345, 1981. DOI: https://doi.org/10.1002/1097-0142(19810115)47:2<343::AID-CNCR2820470222>3.0.CO;2-5
Dexeus - Genetic abnormalities in men with gonadal germ cell tumours. Journal Urology, 140: 80, 1989. DOI: https://doi.org/10.1016/S0022-5347(17)41492-3
Hasle, H.; Meilemgaard, A.; Nielsen, J.; Hansen, J. - Cancer incidence in Klinefelter's syndrome. British Journal of Cancer, 171: 416-420, 1995. DOI: https://doi.org/10.1038/bjc.1995.85
Nichols, C.R.; Heerema, N.A.; Palmer, C., et al. - Klinefeiter's syndrome associated with mediastinal germ cell neoplasm. Journal of Clinical Oncology, 5: 1290-1294, 1987. DOI: https://doi.org/10.1200/JCO.1987.5.8.1290
Landanyi, M.; Samaniego, F.; Reuter, V.E.; Motzer, R.J., et al. - Cytogentic and immunohistochemical evidence for the germ cell origin of a subset of acute leukemias associated with mediatinal germ cell tumors. Journal of the National Cancer lnstitute, 82:22 1-227, 1990. DOI: https://doi.org/10.1093/jnci/82.3.221
Carrol - Testicular fallure in patients with extragonadal germ tumours. Cancer, 60: 108, 1987. DOI: https://doi.org/10.1002/1097-0142(19870701)60:1<108::AID-CNCR2820600120>3.0.CO;2-8
Chaganti, R.S.K.; Rodriguez, E.; Mathew, S. - Origin of adult male mediastinal germ cell tumours. The Lancet, 343: 1130-1132, 1994. DOI: https://doi.org/10.1016/S0140-6736(94)90235-6
Sogge, M.R.; McDonald, S.D.; Cofold, P.B. - Dysgenetic germ cell in Klinefeiter's syndrome. The American Journal of Medicine, 66: 515-518, 1979. DOI: https://doi.org/10.1016/0002-9343(79)91084-2
Friedman - The function of primordial germ cell in extragonadal tissues. International Journal Andrology, 10: 43, 1987. DOI: https://doi.org/10.1111/j.1365-2605.1987.tb00164.x
Beasiey, S.W.; Tiedemann; Howat, A., et al. - Precocious puberty, malignancy and Klinefeiter's. Medical and Pediatric Oncology, 15: 277-280, 1987. DOI: https://doi.org/10.1002/mpo.2950150511
Loehrer, P.J.; Williams, S .D.; Einhorn, L.H. - Testicular cancer: The question continues. Journal of The National Cancer Institute, 180: 1373-1382, 1988. DOI: https://doi.org/10.1093/jnci/80.17.1373
Hasle, H. - Mediastinai germ ceil tumour associated with Klinefelter syndrome. European Journal Pediatric, 151: 375-376, 1992. DOI: https://doi.org/10.1007/BF01959079
