Heterogeneidade celular nos tumores malignos de mama: implicação clínica do estudo de receptores hormonais
DOI:
https://doi.org/10.32635/2176-9745.RBC.1984v30n4.3466Palabras clave:
Câncer de Mama, Receptores de Estrogénio e Progesterona, Método Histoquímico, Heterogeneidade CelularResumen
Conforme demonstrado, os tumores malignos não são entidades uniformes, constituídas por células com características idênticas. Utilizando método histoquímico direto por conjugado hormonal fluorescente, mostra-se que os carcinomas mamários são compostos por população heterogênea, de células receptor-positivas e receptor-negativas em diversas proporções. Nossos resultados comprovam que poucos tumores malignos de mama podem ser considerados como totalmente hormônio-dependentes. Isto explicaria por que em alguns tumores ER+e PgR+, obtêm-se apenas respostas parciais ou curtas remissões pela hormonioterapia. As dificuldades inerentes à racionalização do tratamento são analisadas.
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