Antígenos Tumorais, em Especial o Antígeno Carcinoembriônico
DOI:
https://doi.org/10.32635/2176-9745.RBC.1976v26n5.3812Palabras clave:
Antígenos de Neoplasias/uso terapêutico, Antígeno CarcinoembrionarioResumen
Os antígenos associados a tumores são adjuntos diagnósticos e auxiliares no manuseio terapêutico dos portadores de neoplasias. Os radioimunoensaios para alfa-1-fetoproteína e antigeno carcinoembriônico estão bem padronizados, porém sujeitos a prematura radiólise (1-2 semanas), limitando a possibilidade atual do emprego no Brasil. A revisão efetuada descortina as principais indicações e limitações da dosagem destes antígenos em oncologia.
Descargas
Citas
BUFFE, O. - Les antigènes de tumeurs et leur dótection dans Ie serum: intérêt des méthodes radioimmunologiques. Coli. Instambul IEFA 177/210, 1973.
CHAYVIALLE, J.A. & GANCULI, P.C. - Radioimunoassay of cs-fetoprotein in human plasma. Lanceti :1355,1973. DOI: https://doi.org/10.1016/S0140-6736(73)91676-0
GITLIN, D. & BOESMAN, M. - Serum alpha-fetoprotein. Albumin and fetoglobulin in the human conceptus. J. Clin. Invest. 45:1826, 1966. DOI: https://doi.org/10.1172/JCI105486
GOLO, P. & FREEDMAN, S.O. – Demonstration of tumor specific antigens in human colonic carcinomata by immunological tolerance and absorption tecniques. J. Exp. Med. 121:439, 1965. DOI: https://doi.org/10.1084/jem.121.3.439
GOLO, P. & FREEDMAN, S.O. - Specific carcinoembryonic antigens of the human digestive systems. J. Exp. Med. 122:467, 1965. DOI: https://doi.org/10.1084/jem.122.3.467
GOLDMANN, J. M., GOODMAN, M. & MILLER, O. - Antibody to Epstein-Barr virus in American patients with carcinoma of the pharynx . JAMA 216:1618, 1972. DOI: https://doi.org/10.1001/jama.1971.03180360064009
HANSEN, M.J., LANCE, K.P. & KRUPEY, J.—Demonstration of an ion sensitive antigenic site on carcinoembryonic antigen using Zirconyl phosphate. Clin Res. 19:143, 1971.
INSTITUTO BEHRING (HOECHST) - M-Partigen, So Paulo, 1975.
KLAVINS, J.V., MESA-TEBAJA, R.& VEISS, M. Human carcinoma antigens cross-reacting with antiembryonic antibodies. Nature 234:153, 1971. DOI: https://doi.org/10.1038/newbio234153a0
LAURENCE, D.J,, STEVEN, U., BETTLEHEIM, R. & col, - Role of CEA in dianoses of cancer. Med. J. 3:605, 1972.
LOEWENSTEIN, M. S., KUPCHIK, HZ. & ZAMCHECK, N. - Disparity between CEA-ROCHE "indirect" and "direct' carcinoembryonic antigen values: clinical relevance. N. Engl. Med. J. 294:1123, 1976, DOI: https://doi.org/10.1056/NEJM197605132942019
MACH, J.P. & PUSZTASVERI, G. - Demonstra tion of a partial identity between CEA and another glycoprotein. Immunochemistry 9:1031, 1972. DOI: https://doi.org/10.1016/0019-2791(72)90113-9
MARTIN, E. & MARTIN, M.S. - RIA of CEA in extracts cf human colon and stomach. int. J. Cancer 9: 641, 1972. DOI: https://doi.org/10.1002/ijc.2910090322
MASSEYEFF, R., KREBS, B.P., CASSUTO, J.P. & col. - Dosagem de I'AFP. Intérêt de Ia méthode radioimmunologique in clinique. BuIl. Cancer 60: 383, 1973.
MASSEYEFF, A., BONET, C., DROUET, J. & col. Radioimunoassay of AFP. I. Technique and sérum leveIs in normal adult. Digestion 10:17, 1974. DOI: https://doi.org/10.1159/000197519
MELO, E., MURAMOTO, 1., RASSI, I., BARALDI, V. & ME LO, M. R. - Metodologa de radioisótopos "in vitro", cap. IX. Princípios básicos dos ensaios de saturação. Rev. Bras. Pat. Clin. (em publicação).
REYNOSO, C., CHU, T.M., HOLYOKE, D. & col. CEA in patients with different cancers. JAMA 220: 361, 1972. DOI: https://doi.org/10.1001/jama.1972.03200030021005
RUOSLAHTI, E. & SEPPALA, M. Studies of carcino-fetal proteins. 3. oevelopment of a radioimmunoassay for ca-fetoprotein. Demonstration of cs-fetoprotein in serum of healthy human adults. Int. J. Cancer 8: 374, 1971. DOI: https://doi.org/10.1002/ijc.2910080304
SOROKIN, J.J., SUGARBAKER, P.H., ZAMBCHECK, N. & col. - Serial carcinoembryonic antigen assays: use in detection of cancer recurrence. JAMA 228: 49, 1974. DOI: https://doi.org/10.1001/jama.1974.03230260023017
STEVENS, D.T. & MACKAY, I.R. - Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet 2: 1238, 1973. DOI: https://doi.org/10.1016/S0140-6736(73)90975-6
THOMSON, D.M.P., KRUPEY, J., FREEDMAN, S.0. & col. - The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc. Natl. Acad. Sci. USA 64:161, 1969. DOI: https://doi.org/10.1073/pnas.64.1.161
ZAMCHECK, N. & KUPCHIK, H.Z. - The interdependende of clinical investigations and methodological development in the early evoluation of assays for carcinoembryonic antigen. Cancer Res, 34: 2131, 1974.
