Retrasos en el Inicio del Tratamiento del Cáncer Cervical y Factores Asociados en una Cohorte Hospitalaria de la Amazonía Occidental Brasileña
DOI:
https://doi.org/10.32635/2176-9745.RBC.2025v71n4.5228Palabras clave:
Neoplasias del Cuello Uterino, Tiempo de Tratamiento, Salud de la Mujer, Retraso en el Tratamiento/estadística & datos numéricosResumen
Introducción: El diagnóstico precoz seguido de un tratamiento oportuno del cáncer cervical son fundamentales para un mejor pronóstico y supervivencia. Objetivo: Estimar la magnitud del retraso en el início del tratamiento del cáncer cervical y los factores asociados en mujeres diagnosticadas y tratadas en Rio Branco, Acre, entre 2012 y 2017. Métodos: Estudio transversal de mujeres con cáncer cervical tratadas en Rio Branco, Acre, entre 2012 y 2017. Se categorizó el tiempo entre el diagnóstico y el primer tratamiento según la legislación brasileña. Las variables continuas fueron analizadas con pruebas T-student y Kruskal-Wallis, y las categóricas con X2-Pearson y Fisher. Se calcularon las odds ratios (OR) brutas y ajustadas mediante regresión logística incondicional, con un intervalo de confianza del 95%. Resultados: El tiempo mediano entre el diagnóstico y el primer tratamiento fue de 39 días, con variaciones entre 81 días para cirugía y 29 días para radioterapia. La prevalencia del retraso fue del 34%. Factores asociados al retraso incluyeron edad >40 años, espera >30 días para consulta con especialista y tratamiento quirúrgico. La radioterapia con/sin braquiterapia y los estadios IIIB-IVA estuvieron inversamente relacionados con el retraso. Conclusión: El retraso en el início del tratamiento del cáncer cervical en Acre fue menor que en otras regiones del país. Edad >40 años, esperar >30 días para consulta con especialista y cirugía como primer tratamiento estuvieron asociados positivamente con el retraso, mientras que el estadio avanzado y los tratamientos de radioterapia estuvieron inversamente asociados.
Descargas
Citas
Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: cancer today [Internet]. Lyon: International Agency for Research on Cancer; 2020 [acesso 2024 jun13]. Disponível em: https://gco.iarc.who.int/today/
Silva GA, Jardim BC, Ferreira VM, et al. Cancer mortality in the capitals and in the interior of Brazil: a four-decade analysis. Rev Saúde Pública. 2020;54:126. doi: https://doi.org/10.11606/s1518-8787.2020054002255 DOI: https://doi.org/10.11606/s1518-8787.2020054002255
Jardim BC, Junger WL, Daumas RP, et al. Estimativa de incidência de câncer no Brasil e regiões em 2018: aspectos metodológicos. Cad Saúde Pública. 2024;40(6):e00131623. doi: https://doi.org/10.1590/0102-311XPT131623 DOI: https://doi.org/10.1590/0102-311xpt131623
Incidências do BasePop [Internet]. Rio de Janeiro: INCA; 2023. [acesso 2024 jun 13]. Disponível em: https://www.inca.gov.br/BasePopIncidencias/Home.action
Nakashima JDP, Koifman RJ, Koifman S. Cancer incidence in the Western Amazon: population-based estimates in Rio Branco, Acre State, Brazil, 2007-2009. Cad Saúde Pública. 2012;28(11):2125-32. DOI: https://doi.org/10.1590/S0102-311X2012001100012
International Agency for Research on Cancer. Cervical cancer screening [Internet]. Lyon: IARC; 2022. [acesso 2024 jun 13]. Disponível em: https://publications.iarc.fr/_publications/media/download/5768/2ede2d8620766fdfd85bf922f28c91ec123274f1.pdf
Prendiville W, Sankaranarayanan R. Colposcopy and treatment of cervical precancer [Internet]. Lyon: International Agency for Research on Cancer; 2017. [acesso 2024 jun 13]. Disponível em: https://publications.iarc.fr/Book-And-Report-Series/Iarc-Technical-Publications/Colposcopy-And-Treatment-Of-Cervical-Precancer-2017
Vaccarella S, organizador. Reducing social inequalities in cancer: evidence and priorities for research. Lyon: International Agency for Research on Cancer; 2019. (IARC Scientific Publications; 168).
World Health Organization. WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention. 2. ed. Geneva: World Health Organization; 2021.
Bhatla N, Aoki D, Sharma DN, et al. Cancer of the cervix uteri: 2021 update. Int J Gynaecol Obstet. 2021;155(S1):28-44. doi: https://doi.org/10.1002/ijgo.13865 DOI: https://doi.org/10.1002/ijgo.13865
Abu-Rustum NR, Yashar CM, Arend R, NCCN Guidelines® Insights: cervical cancer, Version 1.2024. J Natl Compr Canc Netw. 2023;21(12):1224-33. doi: https://doi.org/10.6004/jnccn.2023.0062 DOI: https://doi.org/10.6004/jnccn.2023.0062
Marth C, Landoni F, Mahner S, et al. Cervical cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(sup4):iv72-83. doi: https://doi.org/10.1093/annonc/mdx220 DOI: https://doi.org/10.1093/annonc/mdx220
Hansen RP, Vedsted P, Sokolowski I, et al. Time intervals from first symptom to treatment of cancer: a cohort study of 2,212 newly diagnosed cancer patients. BMC Health Serv Res. 2011;11(1):284. doi: https://doi.org/10.1186/1472-6963-11-284 DOI: https://doi.org/10.1186/1472-6963-11-284
Robinson KM, Ottesen B, Christensen KB, et al. Diagnostic delay experienced among gynecological cancer patients: a nationwide survey in Denmark. Acta Obstet Gynecol Scand. 2009;88(6):685-92. doi: https://doi.org/10.1080/00016340902971482 DOI: https://doi.org/10.1080/00016340902971482
Santos TTDM, Andrade LSDS, Oliveira MECD, et al. Availability of diagnostic services and their impact on patient flow in two brazilian referral centres of breast cancer treatment. Asian Pac J Cancer Prev. 2020;21(2):317-24. doi: https://doi.org/10.31557/apjcp.2020.21.2.317 DOI: https://doi.org/10.31557/APJCP.2020.21.2.317
Carvalho PGD, O´Dwer G, Rodrigues NCP. Trajetórias assistenciais de mulheres entre diagnóstico e início de tratamento do câncer de colo uterino. Saúde debate. 2018;42(118):687-701. doi: https://doi.org/10.1590/0103-1104201811812 DOI: https://doi.org/10.1590/0103-1104201811812
Brookfield KF, Cheung MC, Lucci J, et al. Disparities in survival among women with invasive cervical cancer: a problem of access to care. Cancer. 2009;115(1):166-78. DOI: https://doi.org/10.1002/cncr.24007
Perri T, Issakov G, Ben-Baruch G, et al. Effect of treatment delay on survival in patients with cervical cancer: a historical cohort study. Int J Gynecol Cancer. 2014;24(7):1326-32. doi: https://doi.org/10.1097/igc.0000000000000211 DOI: https://doi.org/10.1097/IGC.0000000000000211
Silva IF, Silva IF, Saraceni V, et al. Delays in treatment initiation and conclusion in women with stage IA to IIIB cervical cancer: a survival study in a hospital-based cohort from a developing country. Cancer Epidemiol. 2023;86:102450. doi: https://doi.org/10.1016/j.canep.2023.102450 DOI: https://doi.org/10.1016/j.canep.2023.102450
Chen SW, Liang JA, Yang SN, et al. The adverse effect of treatment prolongation in cervical cancer byhigh-dose-rate intracavitary brachytherapy. Radiother Oncol. 2003;67(1):69-76. doi: https://doi.org/10.1016/s0167-8140(02)00439-5 DOI: https://doi.org/10.1016/S0167-8140(02)00439-5
Nascimento MID, Azevedo e Silva G. Efeito do tempo de espera para radioterapia na sobrevida geral em cinco anos de mulheres com câncer do colo do útero, 1995-2010. Cad Saúde Pública. 2015;31(11):2437-48. doi: https://doi.org/10.1590/0102-311X00004015 DOI: https://doi.org/10.1590/0102-311X00004015
McLaughlin JM, Anderson RT, Ferketich AK, et al. Effect on survival of longer intervals between confirmed diagnosis and treatment initiation among low-income women with breast cancer. J Clin Oncol. 2012;30(36):4493-500. doi: https://doi.org/10.1200/jco.2012.39.7695 DOI: https://doi.org/10.1200/JCO.2012.39.7695
Weller D, Vedsted P, Rubin G, et al. The Aarhus statement: improving design and reporting of studies on early cancer diagnosis. Br J Cancer. 2012;106(7):1262-7. doi: https://doi.org/10.1038/bjc.2012.68 DOI: https://doi.org/10.1038/bjc.2012.68
Chen CP, Kung PT, Wang YH, et al. Effect of time interval from diagnosis to treatment for cervical cancer on survival: a nationwide cohort study. PLoS One. 2019;14(9):e0221946. doi: https://doi.org/10.1371/journal.pone.0221946
Presidência da República (BR). Lei no 12.732 de 22 de novembro de 2012. Dispõe sobre o primeiro tratamento de paciente com neoplasia maligna comprovada e estabelece prazo para seu início. Diário Oficial da União [Internet], Brasília, DF. 2012 nov 23 [acesso 2024 jun 13]; Edição 226; Seção 1:1. Disponível em: https://pesquisa.in.gov.br/imprensa/jsp/visualiza/index.jsp?jornal=1&pagina=1&data=23/11/2012&totalArquivos=240
Assenço KC, Kluthcovsky ACGC, Mansani FP. Atraso no diagnóstico e tratamento de pacientes com câncer de colo de útero atendidas pelo Sistema Único de Saúde em um centro de referência do Sul do Brasil. Mundo Saúde. 2017;41(4):692-702. DOI: https://doi.org/10.15343/0104-7809.20174104692702
Nakagawa JT, Espinosa MM, Barbieri M, et al. Carcinoma do colo do útero: taxa de sobrevida e fatores prognósticos em mulheres no Estado de Mato Grosso. Acta Paulista de Enfermagem. 2011;24(5):631-7. doi: https://doi.org/10.1590/S0103-21002011000500006 DOI: https://doi.org/10.1590/S0103-21002011000500006
Silva IF, Silva IF, Koifman RJ. Cervical cancer treatment delays and associated factors in a cohort of women from a developing country. J Glob Oncol. 2019;(5):1-11. doi: https://doi.org/10.1200/jgo.18.00199 DOI: https://doi.org/10.1200/JGO.18.00199
Silva DS, Pinto MC, Figueiredo MAA. Factors associated with delay in specialized treatment after diagnosis of cervical cancer in Bahia State, Brazil. Cad Saúde Pública. 2022;38(5):e00022421. doi: https://doi.org/10.1590/0102-311xpt022421 DOI: https://doi.org/10.1590/0102-311xpt022421
Jensen OM, International Agency for Research on Cancer, World Health Organization, et al., organizadores. Cancer registration: principles and methods. Lyon: International Agency for Research on Cancer; New York: Distributed in the USA by Oxford University Press; 1991. 288 p. (IARC scientific publications).
Girianelli VR, Gamarra CJ, Azevedo e Silva G. Disparities in cervical and breast cancer mortality in Brazil. Rev Saúde Pública. 2014;48(3):459-67. doi: https://doi.org/10.1590/S0034-8910.2014048005214 DOI: https://doi.org/10.1590/S0034-8910.2014048005214
Silva GA, Alcantara LLM, Tomazelli JG, et al. Avaliação das ações de controle do câncer de colo do útero no Brasil e regiões a partir dos dados registrados no Sistema Único de Saúde. Cad Saúde Pública. 2022;38(7):e00041722. doi: https://doi.org/10.1590/0102-311XPT041722 DOI: https://doi.org/10.1590/0102-311xpt041722
Organização Mundial da Saúde. CID-10: Classificação Estatística Internacional de Doenças e problemas relacionados à saúde. São Paulo: Edusp; 2008.
Coutinho LMS, Scazufca M, Menezes PR. Methods for estimating prevalence ratios in cross-sectional studies. Rev Saúde Pública. 2008;42:992-8. DOI: https://doi.org/10.1590/S0034-89102008000600003
Barros AJ, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003;3(1):21. doi: https://doi.org/10.1186/1471-2288-3-21 DOI: https://doi.org/10.1186/1471-2288-3-21
SPSS®: Statistical Package for Social Science (SPSS) [Internet]. Versão 20.0. [Nova York]. International Business Machines Corporation. [acesso 2023 mar 9]. Disponível em: https://www.ibm.com/br-pt/spss?utm_content=SRCWW&p1=Search&p4=43700077515785492&p5=p&gclid=CjwKCAjwgZCoBhBnEiwAz35Rwiltb7s14pOSLocnooMOQh9qAL59IHVc9WP4ixhNTVMjenRp3-aEgxoCubsQAvD_BwE&gclsrc=aw.ds
Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.
Alves RJV, Watte G, Garcez ADS, et al. Assessment of survival in patients with cervical cancer in a hospital based cohort in Southern Brazil. Braz J Oncolog. 2017;13(46). doi: https://www.doi.org/10.26790/BJO20171346A74
Carneiro SR, Fagundes MDA, Rosário PDJO, et al. Five-year survival and associated factors in women treated for cervical cancer at a reference hospital in the Brazilian Amazon. PLoS One. 2017;12(11):e0187579. doi: https://doi.org/10.1371/journal.pone.0187579 DOI: https://doi.org/10.1371/journal.pone.0187579
Chen CP, Kung PT, Wang YH, et al. Effect of time interval from diagnosis to treatment for cervical cancer on survival: a nationwide cohort study. PLoS One 2019;14(9):e0221946. doi: https://doi.org/10.1371/journal.pone.0221946 DOI: https://doi.org/10.1371/journal.pone.0221946
Wassie M, Argaw Z, Tsige Y, et al. Survival status and associated factors of death among cervical cancer patients attending at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia: a retrospective cohort study. BMC Cancer. 2019;19(1):1221. doi: https://doi.org/10.1186/s12885-019-6447-x DOI: https://doi.org/10.1186/s12885-019-6447-x
Ambroggi M, Biasini C, Del Giovane C, et al. Distance as a barrier to cancer diagnosis and treatment: review of the literature. Oncologist. 2015;20(12):1378-85. doi: https://doi.org/10.1634/theoncologist.2015-0110 DOI: https://doi.org/10.1634/theoncologist.2015-0110
Davis TC, Williams MV, Marin E, et al. Health literacy and cancer communication. CA Cancer J Clin. 2002;52(3):134-49. doi: https://doi.org/10.3322/canjclin.52.3.134 DOI: https://doi.org/10.3322/canjclin.52.3.134
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.