Fotobiomodulación Asociada o No a Otras Técnicas Terapéuticas en el Tratamiento del Linfedema Poscáncer de Mama: Revisión Sistemática de Literatura

Autores/as

DOI:

https://doi.org/10.32635/2176-9745.RBC.2025v71n3.5249

Palabras clave:

Linfedema del Cáncer de Mama, Mastectomía, Terapia por Luz de Baja Intensidad, Revisión Sistemática

Resumen

Introducción: El cáncer de mama es la neoplasia más común entre las mujeres en el Brasil. A pesar de los diversos enfoques terapéuticos, el tratamiento quirúrgico todavía está indicado en muchos casos y comúnmente incluye la biopsia del ganglio linfático centinela o la disección axilar. Estas técnicas se asocian con un mayor riesgo de desarrollar linfedema. Como forma de tratamiento para esta condición crónica, la fotobiomodulación (PBM) se ha destacado por sus efectos en la reducción de la inflamación, edema y fibrosis, favoreciendo la recuperación de los pacientes. Objetivo: Sistematizar los efectos de la PBM como terapia complementaria asociada o no a otras técnicas terapéuticas en el linfedema post cáncer de mama. Método: Revisión sistemática realizada en las bases de datos PubMed/MEDLINE, ScienceDirect, PEDro, BVS y SciELO, utilizando descriptores en portugués e inglés. Se incluyeron ensayos clínicos aleatorizados, sin restricciones de idioma ni periodo de publicación. Resultados: Se incluyeron diez artículos de un total de 227 (todos ensayos clínicos aleatorizados, puntuación PEDro de 6 a 9). La PBM aislada demostró eficacia para reducir el volumen del miembro, mejorar el dolor y la funcionalidad, con efectos más evidentes en los primeros meses y posible mantenimiento a largo plazo. Al asociarlo con otras terapias, los resultados se potenciaron. Conclusión: La PBM parece ser un enfoque complementario prometedor para el tratamiento del linfedema posterior al cáncer de mama, con resultados beneficiosos sobre los síntomas. Se necesitan nuevas investigaciones para estandarizar protocolos que favorezcan la reproducibilidad y ampliar su aplicación en la práctica clínica.

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Citas

Instituto Nacional de Câncer. Estimativa 2023: incidência de câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2022. [Acesso 2025 jan 30]. 162 p. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2023.pdf

Bezerra TS, Rett MT, Mendonça ACR, et al. Hipoestesia, dor e incapacidade no membro superior após radioterapia adjuvante no tratamento para câncer de mama. Rev Dor. 2012;13(4):320-6. doi: https://www.doi.org/10.1590/S1806-00132012000400003 DOI: https://doi.org/10.1590/S1806-00132012000400003

Lovelace DL, McDaniel LR, Golden D. Long-term effects of breast cancer surgery, treatment, and survivor care. J Midwifery Women’s Heal. 2019;64(6):713-24. doi: https://www.doi.org/10.1111/jmwh.13012 DOI: https://doi.org/10.1111/jmwh.13012

Fourgeaud C, Vignes S. New insights in breast cancer-related lymphedema. JMV. 2024;49(3-4):135-40. doi: https://www.doi.org/10.1016/j.jdmv.2024.06.001 DOI: https://doi.org/10.1016/j.jdmv.2024.06.001

Kisner C, Colby LA. Exercícios terapêuticos: fundamentos e técnicas. 5. ed. Barueri: Manole; 2009. 1056 p.

Guirro E, Guirro R. Fisioterapia dermato-funcional: fundamentos, recursos, patologias. 3. ed. Barueri: Manole; 2003.

Boughey JC, Attai D, Chen SL, et al. Contralateral prophylactic mastectomy (CPM) Consensus statement from the American Society of Breast Surgeons: data on CPM outcomes and risks. Ann Surg Oncol. 2016;23(10):3100-5. doi: https://www.doi.org/10.1245/s10434-016-5443-5 DOI: https://doi.org/10.1245/s10434-016-5443-5

Warmuth MA, Bowen G, Prosnitz LR, et al. Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey. Cancer. 1998;83(7):1362-8. doi: https://www.doi.org/10.1002/(sici)1097-0142(19981001)83:7<1362::aid-cncr13>3.0.co;2-2 DOI: https://doi.org/10.1002/(SICI)1097-0142(19981001)83:7<1362::AID-CNCR13>3.0.CO;2-2

Hidding JT, Beurskens CHG, van der Wees PJ, et al. Treatment related impairments in arm and shoulder in patients with breast cancer: a systematic review. PLoS One. 2014;9(5):e96748. doi: https://www.doi.org/10.1371/journal.pone.0096748 DOI: https://doi.org/10.1371/journal.pone.0096748

Leal NFBS, Dias LAR, Carrara HHA, et al. Linfedema pós-câncer de mama: comparação de duas técnicas fisioterapêuticas – estudo piloto. Fisioter Mov. 2011;24(4):647-54.7. doi: https://www.doi.org/10.1590/S0103-51502011000400008 DOI: https://doi.org/10.1590/S0103-51502011000400008

Harris SR, Hugi MR, Olivotto IA, et al. Clinicalpractice guidelines for the care and treatment of breastcancer: 11. Lymphedema. CMAJ. 2001;1634(2):191-9.

Bergmann A, Mattos IE, Koifman RJ. Incidência e prevalência de linfedema após tratamento cirúrgico do câncer de mama: revisão de literatura. Rev Bras Cancerol. 2007;53(4):461-70. doi: https://www.doi.org/10.32635/2176-9745.RBC.2007v53n4.1788 DOI: https://doi.org/10.32635/2176-9745.RBC.2007v53n4.1788

Brennan MJ, DePompolo RW, Garden FH. Focused review: postmastectomy lymphedema. Arch Phys Med Rehabil. 1996;77(Supl 3):S74-80. doi: https://www.doi.org/10.1016/s0003-9993(96)90248-8 DOI: https://doi.org/10.1016/S0003-9993(96)90248-8

Ribeiro RVE. Prevalence of lymphedema after mastectomy in women living with breast cancer: a systematic review of the influence of immediate reconstruction. Rev Bras Cir Plast. 2019;34(1):113-9. doi: https://www.doi.org/10.5935/2177-1235.2019RBCP0017 DOI: https://doi.org/10.5935/2177-1235.2019RBCP0017

Lee KW, Kim SB, Lee JH, et al. Effects of extracorporeal shockwave therapy on improvements in lymphedema, quality of life, and fibrous tissue in breast cancer-related lymphedema. Ann Rehabil Med. 2020;44(5):386-92. doi: https://www.doi.org/10.5535/arm.19213 DOI: https://doi.org/10.5535/arm.19213

Dayan JH, Ly CL, Kataru RP, et al. Lymphedema: pathogenesis and novel therapies. Annu Rev Med. 2018;69:263-76. doi: https://www.doi.org/10.1146/annurev-med-060116-022900 DOI: https://doi.org/10.1146/annurev-med-060116-022900

Nascimento SL, Oliveira RR, Oliveira MMF, et al. Complicações e condutas fisioterapêuticas após cirurgia por câncer de mama: estudo retrospectivo. Fisioter Pesq. 2012;19(3):248-55. doi: https://www.doi.org/10.1590/S1809-29502012000300010 DOI: https://doi.org/10.1590/S1809-29502012000300010

Recchia TL, Prim AC, Luz CM. Upper limb functionality and quality of life in women with five-year survival after breast cancer surgery. Rev Bras Ginecol e Obstet. 2017;39(3):115-22. doi: https://www.doi.org/10.1055/s-0037-1598642 DOI: https://doi.org/10.1055/s-0037-1598642

Morgan PA, Franks PJ, Moffatt CJ. Health-related quality of life with lymphoedema: a review of the literature. Int Wound J. 2005;2(1):47-62. doi: https://www.doi.org/10.1111/j.1742-4801.2005.00066.x DOI: https://doi.org/10.1111/j.1742-4801.2005.00066.x

Meirelles M, Mamede M, Souza L, et al. Avaliação de técnicas fisioterapêuticas no tratamento do linfedema pós-cirurgia de mama em mulheres. Rev Bras Fisioter. 2006;10(4). doi: https://www.doi.org/10.1590/S1413-35552006000400006 DOI: https://doi.org/10.1590/S1413-35552006000400006

Lymphology EC of the IS of. Consensus document of the International Society of Lymphology. Lymphology. 2020;53(1):3-19.

Sá A, Silva T, Pereira TB. Fotobiomodulação no tratamento do câncer de mama photobiomodulation in the treatment of breast cancer. Ciênc Atual. 2023;19(2):36-56.

Silveira PCL, Ferreira KB, Rocha FR, et al. Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on inflammatory response in burn wound healing. Inflammation. 2016;39(4):1395-404. doi: https://www.doi.org/10.1007/s10753-016-0371-x DOI: https://doi.org/10.1007/s10753-016-0371-x

Lawenda BD, Mondry TE, Johnstone PAS. Lymphedema: a primer on the identification and management of a chronic condition in oncologic treatment. CA Cancer J Clin. 2009;59(1):8-24. doi: https://www.doi.org/10.3322/caac.20001 DOI: https://doi.org/10.3322/caac.20001

Baxter GD, Liu L, Tumilty S, et al. Low level laser therapy for the management of breast cancer-related lymphedema: a randomized controlled feasibility study. Lasers Surg Med. 2018;50(9):924-32. doi: https://www.doi.org/10.1002/lsm.22947 DOI: https://doi.org/10.1002/lsm.22947

Ferraresi C, Kaippert B, Avci P, et al. Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3-6 h. Photochem Photobiol. 2015;91(2):411-6. doi: https://www.doi.org/10.1111/php.12397 DOI: https://doi.org/10.1111/php.12397

Chen JC, Chang YW, Hong CC, et al. The role of the VEGF-C/VEGFRs axis in tumor progression and therapy. Int J Mol Sci. 2013;14(1):88-107. doi: https://www.doi.org/10.3390/ijms14010088 DOI: https://doi.org/10.3390/ijms14010088

Hossain L, Gomes KP, Yang X, et al. Vascular endothelial growth factor C (VEGF-C) Sensitizes lymphatic endothelial cells to oxidative-stress-induced apoptosis through DNA damage and mitochondrial dysfunction: implications for lymphedema. Int J Mol Sci. 2024;25(14). doi: https://www.doi.org/10.3390/ijms25147828 DOI: https://doi.org/10.3390/ijms25147828

University of York. Centre for Reviews and Dissemination. New York: University of York; 2019. PROSPERO - International prospective register of systematic reviews. 2023. [acesso 2024 ago 31]. Disponível em: https://www.crd.york.ac.uk/PROSPERO/

Page MJ, Moher D, Bossuyt PM, et al. Prisma 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160. doi: https://doi.org/10.1136/bmj.n160 DOI: https://doi.org/10.1136/bmj.n160

Physiotherapy Evidence Database (PEDro) (Portugal) [Internet]. Sydney: The George Institute for Global Health; 2009. [acesso 2024 ago 31]. Disponível em: https://www.pedro.org.au/portuguese/downloads/pedro-scale/

Kaviani A, Fateh M, Yousefi-Nooraie R, et al. Low-level laser therapy in management of postmastectomy lymphedema. Lasers Med Sci. 2006;21(2):90-4. doi: https://doi.org/10.1007/s10103-006-0380-3 DOI: https://doi.org/10.1007/s10103-006-0380-3

Carati CJ, Anderson SN, Gannon BJ, et al. Treatment of postmastectomy lymphedema with low-level laser therapy: a double blind, placebo-controlled trial. Cancer. 2003;98(6):1114-22. doi: https://doi.org/10.1002/cncr.11641 DOI: https://doi.org/10.1002/cncr.11641

Kozanoglu E, Basaran S, Paydas S, et al. Efficacy of pneumatic compression and low-level laser therapy in the treatment of postmastectomy lymphoedema: a randomized controlled trial. Clin Rehabil. 2009;23(2):117-24. https://doi.org/10.1177/0269215508096173 DOI: https://doi.org/10.1177/0269215508096173

Storz MA, Gronwald B, Gottschling S, et al. Photobiomodulation therapy in breast cancer-related lymphedema: a randomized placebo-controlled trial. Photodermatol Photoimmunol Photomed. 2017;33(1):32-40. doi: https://doi.org/10.1111/phpp.12284 DOI: https://doi.org/10.1111/phpp.12284

Kozanoglu E, Gokcen N, Basaran S, et al. Long-term effectiveness of combined intermittent pneumatic compression plus low-level laser therapy in patients with postmastectomy lymphedema: a randomized controlled trial. Lymphat Res Biol. 2022;20(2):175-84. doi: https://doi.org/10.1089/lrb.2020.0132 DOI: https://doi.org/10.1089/lrb.2020.0132

Yilmaz SS, Ayhan FF. The randomized controlled study of low-level laser therapy, kinesio-taping and manual lymphatic drainage in patients with stage II breast cancer-related lymphedema. Eur J Breast Heal. 2023;19(1):34-44. doi: https://doi.org/10.4274/ejbh.galenos.2022.2022-6-4 DOI: https://doi.org/10.4274/ejbh.galenos.2022.2022-6-4

Ridner SH, Poage-hooper E, Kanar C, et al. A randomized pilot trial evaluating low-level laser therapy as an alternative treatment to manual lymphatic drainage for breast cancer-related lymphedema. Oncol Nurs Forum. 2013;383-93. doi: https://doi.org/10.1188/13.ONF.383-393 DOI: https://doi.org/10.1188/13.ONF.383-393

Földi M, Földi E, Kubik S. Textbook of lymphology: for physicians and lymphedema therapists. 2. ed. Munich: Urban & Fischer; 2006.

Ahmed Omar MT, Abd-El-Gayed Ebid A, El Morsy AM. Treatment of post-mastectomy lymphedema with laser therapy: double blind placebo control randomized study. J Surg Res. 2011;165(1):82-90. doi: https://doi.org/10.1016/j.jss.2010.03.050 DOI: https://doi.org/10.1016/j.jss.2010.03.050

Lau RWL, Cheing GLY. Managing postmastectomy lymphedema with low-level laser therapy. photomed laser surg. 2009;27(5):763-9. doi: https://doi.org/10.1089/pho.2008.2330 DOI: https://doi.org/10.1089/pho.2008.2330

Kilmartin L, Denham T, Fu MR, et al. Complementary low-level laser therapy for breast cancer-related lymphedema: a pilot, double-blind, randomized, placebo-controlled study. Lasers Med Sci. 2020;95-105. doi: https://doi.org/10.1007/s10103-019-02798-1 DOI: https://doi.org/10.1007/s10103-019-02798-1

Lievens PC. The effect of a combined HeNe and i.r. laser treatment on the regeneration of the lymphatic system during the process of wound healing. Lasers Med Sci. 1991;6(2):193-9. DOI: https://doi.org/10.1007/BF02032548

Wang Y, Ge Y, Xing W, et al. The effectiveness and safety of low-level laser therapy on breast cancer-related lymphedema: an overview and update of systematic reviews. Lasers Med Sci. 2022;37(3):1389-413. doi: https://doi.org/10.1007/s10103-021-03446-3 DOI: https://doi.org/10.1007/s10103-021-03446-3

Baxter GD, Liu L, Petrich S, et al. Low level laser therapy (Photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review. BMC Cancer. 2017;17(1):833. doi: https://doi.org/10.1186/s12885-017-3852-x DOI: https://doi.org/10.1186/s12885-017-3852-x

Mahmood D, Ahmad A, Sharif F, et al. Clinical application of low-level laser therapy (Photo-biomodulation therapy) in the management of breast cancer-related lymphedema: a systematic review. BMC Cancer. 2022;22(1):937. doi: https://doi.org/10.1186/s12885-022-10021-8 DOI: https://doi.org/10.1186/s12885-022-10021-8

Chen HY, Tsai HH, Tam KW, Effects of photobiomodulation therapy on breast cancer-related lymphoedema: a systematic review and meta-analysis of randomised controlled trials. Complement Ther Med. 2019;47:102200. doi: https://doi.org/10.1016/j.ctim.2019.102200 DOI: https://doi.org/10.1016/j.ctim.2019.102200

Publicado

2025-08-20

Cómo citar

1.
Reis LS dos, Silva TS da, Januário PG. Fotobiomodulación Asociada o No a Otras Técnicas Terapéuticas en el Tratamiento del Linfedema Poscáncer de Mama: Revisión Sistemática de Literatura. Rev. Bras. Cancerol. [Internet]. 20 de agosto de 2025 [citado 15 de diciembre de 2025];71(3):e-255249. Disponible en: https://rbc.inca.gov.br/index.php/revista/article/view/5249

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REVISIÓN DE LITERATURA