El Papel de los Polimorfismos de Núcleotido Único en los Genes ERCC1, BACH1 y NR5A2 en la Susceptibilidad al Cáncer de Páncreas y la Epidemiología Global: Revisión Sistemática de la Literatura

Autores/as

  • Ana Clara Patrício Barbosa Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0002-2806-2003
  • Camila Carreira Brito Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0006-1150-7490
  • Giovanna Gilioli da Costa Nunes Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0002-9005-0281
  • Natasha Monte da Silva Universidade Federal do Pará (UFPA), Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0000-0003-4061-5045
  • João Victor Souza de Barros Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0001-5618-7578
  • Lethycia Santana de Araujo Castro Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0008-3690-928X
  • João Vitor Smith da Silva Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0006-4971-0558
  • Jerffson Carvalho de Souza Universidade Federal do Pará (UFPA), Faculdade de Medicina, Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0009-0004-1858-753X
  • Laura Patrícia Albarello Gellen Universidade Federal do Pará (UFPA), Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0000-0001-8620-5987
  • Ney Pereira Carneiro dos Santos Universidade Federal do Pará (UFPA), Núcleo de Pesquisas em Oncologia. Belém (PA), Brasil. https://orcid.org/0000-0001-8087-7037

DOI:

https://doi.org/10.32635/2176-9745.RBC.2026v72n1.5363

Palabras clave:

Neoplasias Pancreáticas/etiología, Epidemiología/estadística & datos numéricos, Incidencia, Mortalidad/tendencias, Variación Genética

Resumen

Introducción: El cáncer de páncreas es una de las neoplasias malignas más agresivas, ocupando el duodécimo lugar entre los cánceres más comunes, y la sexta causa principal de muertes relacionadas con el cáncer a nivel mundial. Su etiología es multifactorial, involucrando factores genéticos y no genéticos. Objetivo: Investigar la relación entre los datos epidemiológicos sobre la incidencia y mortalidad global del cáncer de páncreas y variaciones genéticas específicas conocidas como polimorfismos de un solo nucleótido (SNP). Método: Se analizaron 253 SNP, identificados a través de estudios de asociación del genoma completo (GWAS). Las frecuencias alélicas se obtuvieron de bases de datos de poblaciones globales. Utilizando el análisis de correlación de Pearson, se evaluaron las relaciones entre las frecuencias de los SNP, la incidencia y las tasas de mortalidad. Resultados: Los resultados identificaron 16 SNP significativos (p<0,05), entre los cuales rs2816938, rs372883 y rs2236575 fueron altamente significativos (p<0,001). Estas variantes se asociaron principalmente con tasas de mortalidad más elevadas, particularmente en poblaciones europeas y americanas, mientras que las poblaciones africanas y del Sudeste Asiático mostraron frecuencias de SNP más bajas y tasas de mortalidad más reducidas. Los hallazgos sugieren que la predisposición genética desempeña un papel crucial en la susceptibilidad y progresión del cáncer de páncreas. Conclusión: La correlación entre las frecuencias de SNP y los datos epidemiológicos refuerza la influencia de los factores de riesgo genéticos específicos de cada población, destacando la importancia de enfoques personalizados en las estrategias de detección, prevención y tratamiento.

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Citas

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Publicado

2025-10-01

Cómo citar

1.
Barbosa ACP, Brito CC, Nunes GG da C, Silva NM da, Barros JVS de, Castro LS de A, Silva JVS da, Souza JC de, Gellen LPA, Santos NPC dos. El Papel de los Polimorfismos de Núcleotido Único en los Genes ERCC1, BACH1 y NR5A2 en la Susceptibilidad al Cáncer de Páncreas y la Epidemiología Global: Revisión Sistemática de la Literatura. Rev. Bras. Cancerol. [Internet]. 1 de octubre de 2025 [citado 5 de diciembre de 2025];72(1):e-025363. Disponible en: https://rbc.inca.gov.br/index.php/revista/article/view/5363

Número

Vol. 72 Núm. 1 (2026): ene./feb./mar.

Sección

REVISIÓN DE LITERATURA

Licencia

Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.

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Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

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