Cells with dyskeratotic ínclusions in smears from cervix uteri infected by human papillomavírus
DOI:
https://doi.org/10.32635/2176-9745.RBC.1999v45n2.2771Palavras-chave:
cell with dyskeratotic inclusions, koilocytes, cervical condylomaResumo
An additional feature has been reported in cervical smears from patients with human papillomavirus (HPV) infection: the “cell inside another cell”, that shows inclusion bodies in addition to a nuclear smudging (cell with dyskeratotic inclusions: CDl). We observed smears from 129 patients with diagnosis of HPV infection ofthe cervix uteri, stained by Papanicolaou technique. Koilocytes were observed in 48,8% of the patients, and CDI in 30,2% of them. CDI wes presented by 19,3% of the patients. The CDl could not be related to a special type of HPV, therefore it is not a parameter for estimation ofthe oncogenic risk. Further studies are needed to clarify if CDl could be other indirect feature suggestive of HPV infection.
Downloads
Referências
MEISELS A, FORTIN R. Condylomatous lesions of the cervix and vagina I: Cytologic pattems. Acta Cytol, 1976, 20: 506-509.
MEISELS A, ROY M, FORTIER M, MORIN C. Condylomatous lesions of the cervix: Morphologic and colposcopic diagnosis. Am J Diagn Gynecol Obstet, 1979, 1: 109-116.
MEISELS A, ROY M, FORTIER M ET AL. Human papillomavirus infection of the cervix: the atypical condyloma. Acta Cytol, 1981,25: 7-16.
DE BORGES RJ, MIRALLES EP. Aspectos morfológicos y epidemiológicos de Ias llamadas “Atipías koilocíticas”. Rev Obstet Ginecol Venez, 1982, 42: 1-5.
MEISELS A, FORTIN R, ROY M. Condylomatous lesions of the cervix II: Cytologic, colposcopic and histopathologic study. Acta Cytol 21: 379-390, 1977
CRUM CP, NAGAI N, LEVINE RU, SILVERSTEIN S. In situ hybridization analysis of the HPV 16 DNA sequences in early cervical neoplasia. Am JPathol, 1986, 123: 174-182.
GHIRARDINI C, GHINOSI P, RAISI O, PORTOLANl M. Human papillomavirus DNA detection in Papanicolaou-stained cervical smears with a nonradioactive, in situ hybridization assay. Acta Cytol, 1992, 36: 183-188.
LUZZATTO R, RECKTENVALD M LA MAS PORTUGAL JP. Multinucleation and abortive cellular division in human papillomavirus infection. Acta Cytol, 1990, 2: 286-287.
VAN NIEKERK WA. Cervical cytological abnormalities caused by folie acid deficiency. Acta Cytol, 1966, 10; 67-73.
EL-LABBAN NG, OSORIO HERRERA E. Apoptotic bodies and abnormally dividing epithelial cells in squamous cell carcinoma. Histopathology, 1986 10; 921-931. DOI: https://doi.org/10.1111/j.1365-2559.1986.tb02590.x
ARENDS MJ, HARRISON DJ. Apoptosis; Molecular aspects and pathological perspective. In; John Crocker De , Molecular Biology in Histopathology. Baffins Lane, Chichester, West Sussex, England, 1994, 151-170.
ARENS MJ, WYLLIE AH. Apoptosis; Mechanisms and roles in pathology. Int Ver Exp Paíhol, 1991, 32; 223-254. DOI: https://doi.org/10.1016/B978-0-12-364932-4.50010-1
DE BRGES RJ, GARCÍA TAMAYO J, ZAITZMAN M. Cytologic and ultrastructural findings of a peculiar alteration in cervical cells ffom patients with human papillomavirus infections. /Icta Cytol 1989, 3; 314-318.
HERR1NGTON CS, GRAHAM AK, MC GEE JO’D. Interphase Cytonetics IIl: Enhanced sensitivity and flexibility of digoxigenin labelled probes for in situ hybridization. J Clin Paíhol, 1991,44; 33- 38. DOI: https://doi.org/10.1136/jcp.44.1.33
HERRINGTON CS. Human Papillomaviruses (HPV) in gynaecological cytology; from molecular biology to clinical testing. Cytopathology, 1995, 6; 176-189, 1995 DOI: https://doi.org/10.1111/j.1365-2303.1995.tb00471.x
TAKANA H, CHUA K-L, LINDH E, HJERPE A. Patients with various types of human papillomavirus; covariation and diagnostic relevance of cytological findings in Papanicolaou smears. Cytopathology, 1993,4; 273-283. DOI: https://doi.org/10.1111/j.1365-2303.1993.tb00102.x
WIJSMAN JH, JONKER RR, KEIJZER R et al. A new method to detect apoptosis in paraffin sections; insitu end-labeling of fragmented DNA. J Histochem Cytochem, 1993, 41; 7-12, 1993 DOI: https://doi.org/10.1177/41.1.7678025
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
