Cells with dyskeratotic ínclusions in smears from cervix uteri infected by human papillomavírus
DOI:
https://doi.org/10.32635/2176-9745.RBC.1999v45n2.2771Palavras-chave:
cell with dyskeratotic inclusions, koilocytes, cervical condylomaResumo
An additional feature has been reported in cervical smears from patients with human papillomavirus (HPV) infection: the “cell inside another cell”, that shows inclusion bodies in addition to a nuclear smudging (cell with dyskeratotic inclusions: CDl). We observed smears from 129 patients with diagnosis of HPV infection ofthe cervix uteri, stained by Papanicolaou technique. Koilocytes were observed in 48,8% of the patients, and CDI in 30,2% of them. CDI wes presented by 19,3% of the patients. The CDl could not be related to a special type of HPV, therefore it is not a parameter for estimation ofthe oncogenic risk. Further studies are needed to clarify if CDl could be other indirect feature suggestive of HPV infection.
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MEISELS A, FORTIN R. Condylomatous lesions of the cervix and vagina I: Cytologic pattems. Acta Cytol, 1976, 20: 506-509.
MEISELS A, ROY M, FORTIER M, MORIN C. Condylomatous lesions of the cervix: Morphologic and colposcopic diagnosis. Am J Diagn Gynecol Obstet, 1979, 1: 109-116.
MEISELS A, ROY M, FORTIER M ET AL. Human papillomavirus infection of the cervix: the atypical condyloma. Acta Cytol, 1981,25: 7-16.
DE BORGES RJ, MIRALLES EP. Aspectos morfológicos y epidemiológicos de Ias llamadas “Atipías koilocíticas”. Rev Obstet Ginecol Venez, 1982, 42: 1-5.
MEISELS A, FORTIN R, ROY M. Condylomatous lesions of the cervix II: Cytologic, colposcopic and histopathologic study. Acta Cytol 21: 379-390, 1977
CRUM CP, NAGAI N, LEVINE RU, SILVERSTEIN S. In situ hybridization analysis of the HPV 16 DNA sequences in early cervical neoplasia. Am JPathol, 1986, 123: 174-182.
GHIRARDINI C, GHINOSI P, RAISI O, PORTOLANl M. Human papillomavirus DNA detection in Papanicolaou-stained cervical smears with a nonradioactive, in situ hybridization assay. Acta Cytol, 1992, 36: 183-188.
LUZZATTO R, RECKTENVALD M LA MAS PORTUGAL JP. Multinucleation and abortive cellular division in human papillomavirus infection. Acta Cytol, 1990, 2: 286-287.
VAN NIEKERK WA. Cervical cytological abnormalities caused by folie acid deficiency. Acta Cytol, 1966, 10; 67-73.
EL-LABBAN NG, OSORIO HERRERA E. Apoptotic bodies and abnormally dividing epithelial cells in squamous cell carcinoma. Histopathology, 1986 10; 921-931. DOI: https://doi.org/10.1111/j.1365-2559.1986.tb02590.x
ARENDS MJ, HARRISON DJ. Apoptosis; Molecular aspects and pathological perspective. In; John Crocker De , Molecular Biology in Histopathology. Baffins Lane, Chichester, West Sussex, England, 1994, 151-170.
ARENS MJ, WYLLIE AH. Apoptosis; Mechanisms and roles in pathology. Int Ver Exp Paíhol, 1991, 32; 223-254. DOI: https://doi.org/10.1016/B978-0-12-364932-4.50010-1
DE BRGES RJ, GARCÍA TAMAYO J, ZAITZMAN M. Cytologic and ultrastructural findings of a peculiar alteration in cervical cells ffom patients with human papillomavirus infections. /Icta Cytol 1989, 3; 314-318.
HERR1NGTON CS, GRAHAM AK, MC GEE JO’D. Interphase Cytonetics IIl: Enhanced sensitivity and flexibility of digoxigenin labelled probes for in situ hybridization. J Clin Paíhol, 1991,44; 33- 38. DOI: https://doi.org/10.1136/jcp.44.1.33
HERRINGTON CS. Human Papillomaviruses (HPV) in gynaecological cytology; from molecular biology to clinical testing. Cytopathology, 1995, 6; 176-189, 1995 DOI: https://doi.org/10.1111/j.1365-2303.1995.tb00471.x
TAKANA H, CHUA K-L, LINDH E, HJERPE A. Patients with various types of human papillomavirus; covariation and diagnostic relevance of cytological findings in Papanicolaou smears. Cytopathology, 1993,4; 273-283. DOI: https://doi.org/10.1111/j.1365-2303.1993.tb00102.x
WIJSMAN JH, JONKER RR, KEIJZER R et al. A new method to detect apoptosis in paraffin sections; insitu end-labeling of fragmented DNA. J Histochem Cytochem, 1993, 41; 7-12, 1993 DOI: https://doi.org/10.1177/41.1.7678025
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