Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos
DOI:
https://doi.org/10.32635/2176-9745.RBC.1993v39n3.3030Palavras-chave:
Cicatrização das Feridas, Anastomoses Intestinais, Aderências, Cisplatina, Macroscopia, RatosResumo
Os AA. estudaram a ação da cisplatina (cis-diaminocloroplatina-ll) administrada intraperitonealmente sobre a cicatrização de anastomoses do intestino delgado do rato, do ponto de vista macroscópico. Foram operados 48 ratos Wistar, machos, com peso médio de 315,5 gramas, no Laboratório de Cirurgia Experimental do Departamento de Cirurgia da Faculdade de Medicina da Universidade Federal do Rio de Janeiro. Nos 24 animais do grupo-controle foi injetado por via intraperitoneal soro fisiológico a 0,9% (20% do peso corporal) e 24 horas após realizou-se laparotomia mediana associada a ressecção de 1 cm de íleo e anastomose término-terminal com fio de seda 6-0 em plano único total com sutura contínua. Nos ratos do grupo-experimento foi administrada cisplatina (5 mg/kg de peso corporal associada a soro fisiológico a 0,9%, na proporção de 20% do peso corpóreo) e, após um dia, foi efetuado o mesmo procedimento cirúrgico no grupo-controle. Foi feita uma avaliação macroscópica da ferida da parede do abdome, da cavidade peritoneal e da anastomose intestinal. A presença de aderências ocorreu na totalidade dos animais operados, com distintos graus de intensidade. As aderências foram mais extensas e firmes no subgrupo-A2(sete dias com cisplatina). Não foram observadas infecção, deiscências, eventração ou evisceração da ferida cirúrgica da parede abdominal, bem como peritonite, abscessos, fístulas ou deiscências da sutura intestinal em ambos os grupos. Observou-se, macroscopicamente, que em todos os subgrupos com cisplatina foi menor a protuberância ao nível da linha de sutura intestinal do lado intraluminal do segmento do intestino delgado durante a necrópsia.
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