Marcadores Biológicos Potenciais na Avaliação do Câncer da Mama
DOI:
https://doi.org/10.32635/2176-9745.RBC.1982v29n2.3540Palavras-chave:
Neoplasias da Mama/diagnóstico, Receptores de Superfície Celular, Receptores de EstrogênioResumo
Numerosos marcadores biológicos associados a tumor e detectados imunologicamente têm grande aplicabilidade no diagnóstico e monitorização do câncer. Os mais utilizados para a mama são os receptores esteróides e os antígenos de superfície relacionados com as células tumorais. Para que a avaliação hormonal seja mais apurada, sugere-se analisar os receptores de estrogénio e progesterona (ER e PgR). Já para a análise da eficácia terapêutica, sugere-se a monitorização com o antígeno carcinoembriônico (CEA).
Downloads
Referências
ALLEGRA, J.C.; BARLOCK, A.; HUFF, K.K.; LIPPMAN, M.E. - Changes in multiple or sequential ER determinations in breast cancer. Cancer, 45: 792-794, 1980. DOI: https://doi.org/10.1002/1097-0142(19800215)45:4<792::AID-CNCR2820450430>3.0.CO;2-X
ANTONIADES, K.; SPECTOR, H.— Correlation of Estrogen Receptor levels with histology and cytomorphology in human mammary cancer. Am. J. Clin. Pathol., 71: 497-503, 1979. DOI: https://doi.org/10.1093/ajcp/71.5.497
BEATSON, G.T. - Oh the treatment of inoperable cases of carcinoma of the mamma. Suggestions for a new method of treatment, with illustrative cases: Lancet, 2: 104-107, 1896. DOI: https://doi.org/10.1016/S0140-6736(01)72307-0
BEATTY, J.D.; ROMERO, C.; BROWN, P.W.: LAWRENCE Jr., W.; TERZ, J.J. — Clinical value of Carcinoembryonic Antigen. Diagnosis, prognosis, and follow-up of patients with cancer. Arch Surg., 114: 563-567, 1979. DOI: https://doi.org/10.1001/archsurg.1979.01370290013002
BURKE, R.E.; MIRA, J.G.; DATTA, R; ZAVA, D.T.; McGUIRE, W.L. - Estrogen action following irradiation of human breast cancer cells. Cancer Res., 38: 2813-2817, 1978.
COOMBES, R.C.; POWLES, T.J.- GAZET, J.C.; NASH, A.G.; FORD, H.T.; McKINNA, A; NEVILLE, A.M. — Assessment of biochemical tests to screen for metastases in patients with breast cancef. Lancet, 9, 8163: 296-291, 1980. DOI: https://doi.org/10.1016/S0140-6736(80)90790-4
COOPER, A.P.: — In: The principles and practice of surgery. Vol. I. ed. London, E. Cox: 333-335; 1836 (Citado por Jensen E.V. in: Cancer 46 (suppl.): 2759-2761,1980). DOI: https://doi.org/10.1002/1097-0142(19801215)46:12+<2759::AID-CNCR2820461402>3.0.CO;2-7
De SOMBRE, E.R.; GREENE, G.L. JENSEN, E.V. — Estrophilin and endocrine responsiveness of breast cancer. In: Hormones, Receptors and Breast Cancer. Raven Press, NY ed. Mc Guire: 1-14, 1978.
FALKSON, H.C.;VAN DER WATT, J.J.; PORTUGAL, M.A. PITOUT. M.S.; FALKSON, G. Carcinoembryonic Antigen in patients with breast cancer. An adjuntive tool to monitor response and therapy. Cancer, 42: 1308, 1313, 1978. DOI: https://doi.org/10.1002/1097-0142(197809)42:3<1308::AID-CNCR2820420341>3.0.CO;2-N
FRANCHIMONT, P.; ZANGERLE P.F.; NOGAREDE, J.; BURY F MOLTER, F.; REUTER, A.; HENDRICK.S.C.; COLLETTE, J. -Simultaneous assays of cancer - associated antigens in various neoplastic disorders. Cancer, 88: 2287-2295, 1976. DOI: https://doi.org/10.1002/1097-0142(197612)38:6<2287::AID-CNCR2820380616>3.0.CO;2-2
GOLD, P.; FREEDMAN, S.O. - Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med., 121: 439-459, 1965. DOI: https://doi.org/10.1084/jem.121.3.439
GRODIN, J.M.; SÜTERI, P.K.; Mac DONALD, P.C. — Surce of Estrogen production in postmenopausal women J. Clin. Endocrinot. Metab., 36: 207-214, 1973. DOI: https://doi.org/10.1210/jcem-36-2-207
HAAGENSEN Jr., D.E.; KISTER, S.J.; VANDEVOORDE, J.P.; GATES, J.B.; SMART, E.K.; HANSEN, H.J.; WELLS J.r., S.A. — Evaluation of CEA as a plasma monitor for human breast carcinoma. Cancer, 42: (SuppI.): 1512-1 519, 1978. DOI: https://doi.org/10.1002/1097-0142(197809)42:3+<1512::AID-CNCR2820420824>3.0.CO;2-6
HAHNEL, R.; WOODINGS, T.; VIVIAN, A.B. — Prognostic value of Estrogen Receptors in primary breast cancer. Cancer, 44: 671 -675, 1979. DOI: https://doi.org/10.1002/1097-0142(197908)44:2<671::AID-CNCR2820440238>3.0.CO;2-V
HANSEN, H.J.; SNYDER, J.J.; MILLER, E.; VANDEVOORDE, J.P.; MILLER, O.N.; HINES, L.R.; BURNS, J.J. — Carcinoembryonic Antigen assay. A laboratory adjunct in the diagnosis and management of cancer. Human Pathol., 5: 139-147, 1974. DOI: https://doi.org/10.1016/S0046-8177(74)80061-4
HEUSON, J.C.; LONGEVAL, E.; MATTHEIEM, W.H.; DEBOEL, M. C.; SYLVESTER, R.J.; LECLERCQ. G. — Significance of quantitative assessment of ER for endocrine therapy in advanced breast cancer. Cancer, 39: 1971-1977; 1977. DOI: https://doi.org/10.1002/1097-0142(197705)39:5<1971::AID-CNCR2820390510>3.0.CO;2-8
HEUSON, J.C.; LECLERCQ, G.; LONGEVAL, E.; DEBOEL, M.C.- MATTHEIEM, W.H.; HEIMANN, R. — Estrogen Receptors: Prognostic significance in breast cancer. In: Estrogen receptors in human breast cancer. Raven Press, N.Y., ed. W.L. McGuire: 57-72, 1975.
HUGGINS, C.; BERGENSTAL, D. M. — Inibition of human mammary and prostatlc cancers by adrenalectomy. Cancer Res., 12: 134-141, 1952.
JENSEN, E.V. — Estrogen Receptors in hormone-dependent breast cancers. Cancer Res., 35: 3362-3364, 1975.
KNIGHT, W.A.; LIVINGSTON, R. B.; GREGORY, E.J.; McGUIRE, W.L. — Estrogen Receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res., 37: 4669-4771, 1977.
LECLERCQ, G.; HEUSON, J.C.; DE BOEL. M.C.; LEGROS. N.: LONGEVAL, E.; MATTHEIM.W.H. - Estrogen and Progesterone Receptors in human breast cancer. In: Progesterone Receptors in normal and neoplastic tissues. Raven Press, N.Y. ed. W.L. McGuire: 141-153, 1977.
LEE, S.H. Cytochemical study of Estrogen Receptor in human mammary cancer. Amer. J. Clin. Pathol. 70: 197-203, 1978. DOI: https://doi.org/10.1093/ajcp/70.2.197
LIPPMAN, M.E.; ALLEGRA, J.C.- THOMPSON, E.B.; SIMON, R.- BARLOCK, A.; GREEN, L; HUFF, K. K.; DO, H.M.T.; AITKEN, S.C.; WARREN, R. — The relation between Estrogen Receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N. Engl. J. Med., 298: 1223-1228, 1978. DOI: https://doi.org/10.1056/NEJM197806012982203
Lo GERFO, P.; KRUPEY, J.; HANSEN, H.J. — Demonstration of anantigen common to several varieties of neoplasia. N. England. J. Med.; 285: 138-141, 1971. DOI: https://doi.org/10.1056/NEJM197107152850302
LOKICH, J.J.; ZAMCHECK, N.; LOWNSTEIN, M.W. – Sequential Carcinoembryonic Antigen levels in the therapy of metastatic breast cancer. A predictor and monitor of response and relepse. Ann. Intern. Med., 89: 902-906, 1978. DOI: https://doi.org/10.7326/0003-4819-89-6-902
LUFT, R.; OLIVECRONA, H. - Experiences with hypophysectomy in man. J. Neurosurg., 10: 301-316, 1953. DOI: https://doi.org/10.3171/jns.1953.10.3.0301
Mac SWEEN.J.M.; WARNER, N.L.; BANKHURST, A.D.; Mac KAY, I. R. — Carcinoembryonic Antigen in whole serum. Br. J. Cancer, 26: 356-360, 1972. DOI: https://doi.org/10.1038/bjc.1972.46
MARTIN. Jr., E.W.; KIBBEY, W.E.; Di VECCHIA, I.; ANDERSON, G.; CATALANO, P.; MENTON, J.P. - Carcinoembryonic Antigen Clinical and historical aspects. Cancer, 37: 62-81, 1976. DOI: https://doi.org/10.1002/1097-0142(197601)37:1<62::AID-CNCR2820370110>3.0.CO;2-#
Mc CARTY, Jr. K.; BARTON, T.K.; FETTER, B.F.; WOODARD, B.H.; MOSSLER, J.A.; REEVS, W.; DALY, J.; WILKINSON, W.E.; Mc CARTY, K.S. - Correlation of Estrogen and Progesterone Receptors with histologic differentiation in mammary carcinoma. Cancer, 46: 2851-2858, 1980. DOI: https://doi.org/10.1002/1097-0142(19801215)46:12+<2851::AID-CNCR2820461424>3.0.CO;2-K
Mc GUIRE, W.L. — Estrogen Receptors in human breast cancer. J. Clin. Invest, 52: 73-77, 1973. DOI: https://doi.org/10.1172/JCI107175
McGUIRE, W.; HORWITZ, K.B.- Progesterone Receptors in breast cancer In: Hormones, Receptors, and Breast cancer. Raven Press, N. Y., ed. Mc Guire: 31-42, 1978. DOI: https://doi.org/10.1016/B978-0-12-526302-3.50019-8
MERCER, W.; WAHL, T.; CARLSON, C.; TEAGUE, P. - Identification of Estrogen and Progesterone Receptors in breast cancer cells by immunological techniques. Feder. Proced., 38: (3 part II): 913,1979.
MlULS, R.R. — Correlation of hormone Receptors with pathological features in human breast cancer. Cancer, 46: 2869-2871, 1980. DOI: https://doi.org/10.1002/1097-0142(19801215)46:12+<2869::AID-CNCR2820461426>3.0.CO;2-Q
PEARSON, O.H.; RAY, B.S.; HARROLD, C.C. et al. — Hypophysectomy in treatment of advanced cancer. J. Am. Med. Assoc., 161: 17-21, 1956. DOI: https://doi.org/10.1001/jama.1956.02970010019005
POMPECKI, R.; SCHROEDER, G.; GARBRECHT, M.; FRAHM, H. - Carcinoembryonic Antigen (CEA) in patients with metastatic breast cancer. Under endocrine therapeutic treatment. Dtsch. Med. Wochenschr, 103: 620-622, 1978. DOI: https://doi.org/10.1055/s-0028-1104486
ROSEN, P.P.; MENENDES-BOTET, C.J.; SENIE, R.T.; SCHWARTZ, M. K.; SCHOTTENFELD, D.; FARR, G.H. — Estrogen Receptor Protein (ERP) and the histopathology of human mammary carcinoma. In: Hormones, Receptors and Breast cancer. Raven Press, N.Y.; ed. Mc Guire: 71-83, 1978.
ROSEN. P.P.; MENENDES-BOTET, C.J.; URBAN, J.A.; FRACCHIA. A.; SCHWARTZ, M.K. - Estrogen Receptor Protein (ERP) in multiple tumor specimens from individual patients with breast cancer. Cancer, 39: 2194-2200, 1977. DOI: https://doi.org/10.1002/1097-0142(197705)39:5<2194::AID-CNCR2820390537>3.0.CO;2-Y
RUBENS, R.D.; KING, R.B. - Oestrogen receptors and response to cytotoxic chemotherapy. Proceedings of Amer. Assoe, for Cancer Res., 20: 304, 1979.
SAEZ, S.; MAYER, M. – Facteurs hormonaux de prévision d'harmonodépendance du câncer di sein. Bull. du Câncer, 64: 557-565, 1977.
SAMAAN, N.A.; BUZDAR, A.U.; ALDINGER, K.A.; SCHULTZ, P.N.; YANG, K.P.; - ROMSDAHL M.M.; MARTIN, R. — Estrogen Receptor: A prognostic factor in breast cancer. Cancer, 47: 554-560, 1981. DOI: https://doi.org/10.1002/1097-0142(19810201)47:3<554::AID-CNCR2820470322>3.0.CO;2-W
STEWARD, A.M.; NIXON, D.W.; ZAMCHECK, N.; AISENBERG, A. — Carcinoembryonic Antigens in breast cancer patients serum levels and disease progress. Cancer, 33: 1246-1252, 1974. DOI: https://doi.org/10.1002/1097-0142(197405)33:5<1246::AID-CNCR2820330509>3.0.CO;2-O
THOMPSON, D.M.P.; KRUPEY, J.; FREEDMAN, S.O.; GOLO, P. – The radioimunoassay of circulating Carcinoembryonic Antigen of the human digestive System. Proc. Natl. Acad. Sci. USA, 64: 161-167, 1969. DOI: https://doi.org/10.1073/pnas.64.1.161
TORMEY, D.C.; WALLKES, T.P. — Clinical correlation between CEA and breast cancer. Cancer, 42 (Suppl): 1507-1 511, 1978. DOI: https://doi.org/10.1002/1097-0142(197809)42:3+<1507::AID-CNCR2820420823>3.0.CO;2-W
TORMEY, D.C;; WAALKES, T.P.; SNYDER, J.J.; SIMON, R.M. - Biological markers in breast carcinomas (III Clinical correlation with Carcinoembryonic Antigens). Cancer, 39: 2397-2404, 1977. DOI: https://doi.org/10.1002/1097-0142(197706)39:6<2397::AID-CNCR2820390614>3.0.CO;2-N
VIDER, M.; KASHMIRI, R.; HUNTER, L. et al. — Carcinoembryonic Antigen (CEA) monitoring in management of radiotherapeutic patients. Oncology (Basel) 30. 257-272, 1974. DOI: https://doi.org/10.1159/000224965
WAHREN, B.; LIDBRINK, E.; WALLGREN, A.; ENEROTH, P.; ZAJFCEK, J. — Carcinoembryonic Antigen and other tumor markers in tissue and serum or plasma of patients with primary mammary carcinoma. Cancer, 42: 1870-1878, 1978. DOI: https://doi.org/10.1002/1097-0142(197810)42:4<1870::AID-CNCR2820420426>3.0.CO;2-Y
WALT, A.J.; SINGHAKOWITA, A.; BROOKS, S.C.; CORTEZ, A. - The surgical implications of estrophile protein estimations in carcinoma of the breast. Surgery, 80: 506-512, 1976.
WANG, D.Y.; BULBROOK, R.D.; HAYWARD, J.L. et al. - Relationship between plasma Carcinoembryonic Antigen and prognosis in women with breast cancer. Eur. J. Cancer, 11: 615-618, 1975. DOI: https://doi.org/10.1016/0014-2964(75)90094-8
WITTLIFF, J.L. - Specific Receptors of the Steroid Hormones in breast cancer. Semin. OncoL, 1: 109-118, 1974.
WITTLIFF, J.L.; HILF, R.; BROOKS Jr., W.F.; SAVLOV, E.O.; HALL, T.C.; ORLANDO, R.A. - Specific Estrogen-binding capacity of the cytoplasmic Receptor in normal and neoplastic breast tissues of humans. Cancer Res., 32: 1983-1992, 1972.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
