Influência da Idade na Qualidade de Vida Relacionada à Saúde de Mulheres Diagnosticadas com Câncer de Mama
DOI:
https://doi.org/10.32635/2176-9745.RBC.2023v69n2.3826Palavras-chave:
neoplasias da mama, qualidade de vida, inquéritos e questionários, fatores etáriosResumo
Introdução: Mulheres com câncer de mama podem apresentar diferenças na qualidade de vida relacionada à saúde (QVRS) ao diagnóstico de acordo com a idade. Objetivo: Analisar a influência da idade na QVRS de mulheres com diagnóstico de câncer de mama. Método: Estudo transversal com mulheres diagnosticadas com câncer de mama. A avaliação da QVRS foi realizada antes do início do tratamento oncológico por meio do questionário European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) e seu módulo específico para o câncer de mama (BR-23). A associação entre faixa etária e QVRS foi determinada por meio da regressão linear múltipla. Resultados: Foram incluídas 961 mulheres com média de idade de 54 anos (DP±11,7). Mulheres com idade ≥50 anos apresentaram melhor função emocional (+7,6 pontos; p<0,001), menos fadiga (-4,4 pontos; p=0,014), dor (-4,7 pontos; p=0,033), náuseas e vômitos (-2,3 pontos; p=0,030) e dificuldade financeira (-10,3 pontos; p<0,001) comparadas as mulheres jovens. Em relação ao BR-23, essas mulheres apresentaram melhor escores de imagem corporal (+3,6 pontos; p=0,029) e de perspectiva futura (+12,4 pontos; p<0,001), e piores função sexual (-19,9 pontos; p<0,001) e satisfação sexual (-8,9 pontos; p=0,001); e, na escala de sintomas, menos sintomas na mama (-11,6 pontos; p<0,001) e sintomas no braço (-3,5 pontos; p=0,047). Conclusão: As pacientes com idade ≥50 anos apresentaram melhor QVRS em todos os domínios das escalas de função e escalas de sintomas do QLQ C-30 e BR-23, exceto no que diz respeito a função sexual e a satisfação sexual.
Downloads
Referências
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. doi: https://doi.org/10.3322/caac.21660 DOI: https://doi.org/10.3322/caac.21660
Tsaras K, Papathanasiou IV, Mitsi D, et al. Assessment of depression and anxiety in breast cancer patients: prevalence and associated factors. Asian Pac J Cancer Prev. 2018;19(6):1661-69. doi: https://doi.org/10.22034/APJCP.2018.19.6.1661
Brunault P, Champagne AL, Huguet G, et al. Major depressive disorder, personality disorders, and coping strategies are independent risk factors for lower quality of life in non-metastatic breast cancer patients. Psychooncology. 2016;25(5):513-20. doi: https://doi.org/10.1002/pon.3947 DOI: https://doi.org/10.1002/pon.3947
Gold M, Dunn LB, Phoenix B, et al. Co-occurrence of anxiety and depressive symptoms following breast cancer surgery and its impact on quality of life. Eur J Oncol Nurs. 2016;20:97-105. doi: https://doi.org/10.1016/j.ejon.2015.06.003 DOI: https://doi.org/10.1016/j.ejon.2015.06.003
Cho YU, Lee BG, Kim SH. Coping style at diagnosis and its association with subsequent health-related quality of life in women with breast cancer: a 3-year follow-up study. Eur J Oncol Nurs. 2020;45:101726. doi: https://doi.org/10.1016/j.ejon.2020.101726 DOI: https://doi.org/10.1016/j.ejon.2020.101726
De Aguiar SS, Bergmann A, Mattos IE. Quality of life as a predictor of overall survival after breast cancer treatment. Qual Life Res. 2014;23(2):627-37. doi: https://doi.org/10.1007/s11136-013-0476-8 DOI: https://doi.org/10.1007/s11136-013-0476-8
Karlsen RV, Frederiksen K, Larsen MB, et al. The impact of a breast cancer diagnosis on health-related quality of life. A prospective comparison among middle-aged to elderly women with and without breast cancer. Acta Oncol. 2016;55(6):720-7. doi: https://doi.org/10.3109/0284186X.2015.1127415 DOI: https://doi.org/10.3109/0284186X.2015.1127415
Mierzynska J, Taye M, Pe M, et al. Reference values for the EORTC QLQ-C30 in early and metastatic breast cancer. Eur J Cancer. 2020;125:69-82. doi: https://doi.org/10.1016/J.Ejca.2019.10.031 DOI: https://doi.org/10.1016/j.ejca.2019.10.031
Sitlinger A, Zafar SY. Health-related quality of life: the impact on morbidity and mortality. Surg Oncol Clin N Am. 2018;27(4):675-84. doi: https://doi.org/10.1016/j.soc.2018.05.008 DOI: https://doi.org/10.1016/j.soc.2018.05.008
Sinha R, Coyle C, Ring A. Breast cancer in older patients: national cancer registry data. Int J Clin Pract. 2013;67(7):698-700. doi: https://doi.org/10.1111/ijcp.12117 DOI: https://doi.org/10.1111/ijcp.12117
Park JH, Jung YS, Kim JY, et al. Trajectories of health-related quality of life in breast cancer patients. Support Care Cancer. 2020;28(7):3381-9. doi: https://doi.org/10.1007/s00520-019-05184-3 DOI: https://doi.org/10.1007/s00520-019-05184-3
Tejeda S, Stolley MR, Vijayasiri G, et al. Negative psychological consequences of breast cancer among recently diagnosed ethnically diverse women. Psychooncology. 2017;26(12):2245-52. doi: https://doi.org/10.1002/pon.4456 DOI: https://doi.org/10.1002/pon.4456
Champion VL, Wagner LI, Monahan PO, et al. Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains. Cancer. 2014;120(15):2237-46. doi: https://doi.org/10.1002/cncr.28737 DOI: https://doi.org/10.1002/cncr.28737
Wöckel A, Schwentner L, Krockenberger M, et al. Predictors of the course of quality of life during therapy in women with primary breast cancer. Qual Life Res. 2017;26(8):2201-8. doi: https://doi.org/10.1007/s11136-017-1570-0 DOI: https://doi.org/10.1007/s11136-017-1570-0
Assogba ELF, Kamga AM, Costaz H, et al. What are young women living conditions after breast cancer? Health-related quality of life, sexual and fertility issues, professional reinsertion. Cancers (Basel). 2020;12(6):1564. doi: https://doi.org/10.3390/cancers12061564 DOI: https://doi.org/10.3390/cancers12061564
Michels FAS, Latorre MR, Maciel MS. Validity, reliability and understanding of the EORTC-C30 and EORTC-BR23, quality of life questionnaires specific for breast cancer. Rev Bras Epidemiol. 2013;16(2):352-63. doi: https://doi.org/10.1590/S1415-790X2013000200011 DOI: https://doi.org/10.1590/S1415-790X2013000200011
Fayers P, Bottomley A; EORTC Quality of Life Group, et al. Quality of life research within the EORTC-the EORTC QLQ-C30. Eur J Cancer. 2002;38(Suppl 4):S125-33. doi: https://doi.org/10.1016/s0959-8049(01)00448-8 DOI: https://doi.org/10.1016/S0959-8049(01)00448-8
Conselho Nacional de Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção 1:59.
Tran TH, Trinh NL, Hoang Y, et al. Health-related quality of life among vietnamese breast cancer women. Cancer Control. 2019;26(1):1073274819862787. doi: https://doi.org/10.1177/1073274819862787 DOI: https://doi.org/10.1177/1073274819862787
Hamer J, McDonald R, Zhang L, et al. Quality of life (QOL) and symptom burden (SB) in patients with breast cancer. Support Care Cancer. 2017;25(2):409-19. doi: https://doi.org/10.1007/s00520-016-3417-6 DOI: https://doi.org/10.1007/s00520-016-3417-6
Pinheiro LC, Tan X, Olshan AF, et al. Examining health-related quality of life patterns in women with breast cancer. Qual Life Res. 2017;26(7):1733-43. doi: https://doi.org/10.1007/s11136-017-1533-5 DOI: https://doi.org/10.1007/s11136-017-1533-5
Howard-Anderson J, Ganz PA, Bower JE, et al. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(5):386-405. doi: https://doi.org/10.1093/jnci/djr541 DOI: https://doi.org/10.1093/jnci/djr541
Leinert E, Singer S, Janni W, et al. The impact of age on quality of life in breast cancer patients receiving adjuvant chemotherapy: a comparative analysis from the prospective multicenter randomized ADEBAR trial. Clin Breast Cancer. 2017;17(2):100-6. doi: https://doi.org/10.1016/j.clbc.2016.10.008 DOI: https://doi.org/10.1016/j.clbc.2016.10.008
Dialla PO, Chu WO, Roignot P, et al. Impact of age-related socio-economic and clinical determinants of quality of life among long-term breast cancer survivors. Maturitas. 2015;81(3):362-70. doi: https://doi.org/10.1016/j.maturitas.2015.03.025 DOI: https://doi.org/10.1016/j.maturitas.2015.03.025
Franzoi MA, Rosa DD, Zaffaroni F, et al. Advanced stage at diagnosis and worse clinicopathologic features in young women with breast cancer in Brazil: a subanalysis of the AMAZONA III study (GBECAM 0115). J Glob Oncol. 2019;5:1-10. doi: https://doi.org/10.1200/JGO.19.00263 DOI: https://doi.org/10.1200/JGO.19.00263
Imran M, Al-Wassia R, Alkhayyat SS, et al. Assessment of quality of life (QoL) in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires: a tertiary care center survey in the western region of Saudi Arabia. PLoS One. 2019;14(7):e0219093. doi: https://doi.org/10.1371/journal.pone.0219093 DOI: https://doi.org/10.1371/journal.pone.0219093
Fobair P, Spiegel D. Concerns about sexuality after breast cancer. Cancer J. 2009;15(1):19-26. doi: https://doi.org/10.1097/PPO.0b013e31819587bb DOI: https://doi.org/10.1097/PPO.0b013e31819587bb
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.