Sentinel Node Biopsy after Neoadjuvant Chemotherapy in Breast Cancer: Real Life Results

Autores

  • Marcelo Adeodato Bello Instituto Nacional de Câncer (INCA), Hospital do Câncer III (HCIII). Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0002-0843-6066
  • Anke Bergmann Instituto Nacional de Câncer (INCA), Programa de Epidemiologia Clínica. Rio de Janeiro (RJ), Brasil https://orcid.org/0000-0002-1972-8777
  • Suzana Sales de Aguiar Instituto Nacional de Câncer (INCA), Programa de Epidemiologia Clínica. Rio de Janeiro (RJ), Brasil https://orcid.org/0000-0003-1963-1294
  • Marcelo Morais Barbosa Instituto Nacional de Câncer (INCA), Hospital do Câncer III (HCIII). Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0001-8654-8269
  • Emanuelle Narciso Alvarez Valente Instituto Nacional de Câncer (INCA), Hospital do Câncer III (HCIII). Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0002-6539-2864
  • Luiz Claudio Santos Thuler Instituto Nacional de Câncer (INCA), Programa de Epidemiologia Clínica. Rio de Janeiro (RJ), Brasil https://orcid.org/0000-0003-2550-6537

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n3.4683

Palavras-chave:

Tratamento Farmacológico, Neoplasias da Mama/cirurgia, Excisão de Linfonodo, Biópsia de Linfonodo Sentinela, Demografia

Resumo

Introdução: O câncer de mama (CM) é o mais comum entre as mulheres. A quimioterapia neoadjuvante (QTNEO) visa melhorar as condições cirúrgicas em pacientes com CM localmente avançado. Objetivo: Comparar as características demográficas, clínicas e de tratamento de mulheres submetidas à QTNEO para tratamento de CM de acordo com a linfadenectomia axilar (LA) ou biópsia de linfonodo sentinela (BLS) e analisar os fatores associados à indicação de BLS em um cenário da vida real. Método: Estudo de coorte retrospectivo em mulheres com CM e indicação de QTNEO. Foram obtidas variáveis demográficas, clínicas, tumorais e de tratamento. Foi realizada regressão logística simples e múltipla para avaliar os fatores independentes associados à indicação de BLS. Resultados: Foram incluídas 918 pacientes, das quais 17,5% foram submetidas à BLS e 11,4% à BLS seguida de LA. As mulheres em estádio III tiveram 95% menos probabilidade de serem submetidas à BLS (OR = 0,05; IC 95%: 0,01-0,17; p < 0,001) em comparação com aquelas no estádio I. As submetidas à mastectomia apresentaram 90% menor chance de realizar BLS do que aquelas com cirurgia conservadora (IC95%: 0,06-0,17; p < 0,001). Considerando as respostas da QTNEO, os casos sem resposta ou com progressão da doença apresentaram chance 55% menor de serem submetidos à BLS em comparação às que apresentaram resposta total (OR = 0,45; IC 95%: 0,24-0,82; p = 0,009). Conclusão: A BLS foi realizada em 29% das pacientes após QTNEO. Pacientes que apresentavam estágio clínico mais avançado da doença e pior resposta à QTNEO e as que foram submetidas a mastectomias tiveram menor probabilidade de serem submetidas à BLS.

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2024-06-28

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Bello MA, Bergmann A, Aguiar SS de, Barbosa MM, Valente ENA, Thuler LCS. Sentinel Node Biopsy after Neoadjuvant Chemotherapy in Breast Cancer: Real Life Results. Rev. Bras. Cancerol. [Internet]. 28º de junho de 2024 [citado 22º de julho de 2024];70(3):e-024683. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/4683

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