Evaluation of the Effect of Preventive Laser on Chemo-induced Oral Mucositis in Patients Submitted to High Doses of Methotrexate

Authors

  • Lilian de Jesus Neves Hospital de Câncer Infantojuvenil de Barretos. Departamento de Odontologia. Barretos (SP), Brasil. https://orcid.org/0000-0001-5194-4368
  • Érica Boldrini Hospital de Câncer Infantojuvenil de Barretos. Departamento de Odontologia. Barretos (SP), Brasil. https://orcid.org/0000-0001-8450-8730
  • Hélio Massaiochi Tanimoto Hospital de Câncer Infantojuvenil de Barretos. Departamento de Odontologia. Barretos (SP), Brasil. https://orcid.org/0000-0003-1862-5466
  • Deny Munari Trevisani Hospital de Câncer Infantojuvenil de Barretos. Departamento de Odontologia. Barretos (SP), Brasil. https://orcid.org/0000-0002-2104-952X
  • Luiz Fernando Lopes Hospital de Câncer Infantojuvenil de Barretos. Departamento de Odontologia. Barretos (SP), Brasil. https://orcid.org/0000-0001-9737-9245
  • Karina Silva Moreira Macari Hospital de Câncer Infantojuvenil de Barretos. Departamento de Odontologia. Barretos (SP), Brasil. https://orcid.org/0000-0002-7220-0074

DOI:

https://doi.org/10.32635/2176-9745.RBC.2021v67n1.1128

Keywords:

Stomatitis/drug therapy, Methotrexate, Low-Level Light Therapy, Pediatric Dentistry

Abstract

Introduction: Chemotherapy, one of the treatments for malignant neoplasms, is associated to innumerous drugs, one of them methotrexate (MTX), of high toxicity, responsible for several health damages and impact on the patient’s well-being. One of the main complications is oral mucositis, a clinical manifestation resulting from the oncologic treatment that can interfere in the treatment and cure. Objective: To evaluate comparatively through a retrospective study, the effect of preventive laser in the occurrence of chemo-induced oral mucositis in patients with non-metastatic osteosarcoma submitted to high doses of methotrexate (MTX), and the intensity of oral mucositis, using the preventive laser after the chemotherapy cycles containing the drug methotrexate (MTX) in the patients treated at the Child and Adolescent Cancer Hospital of Barretos/SP. Method: Retrospective cohort study with charts review. The patients were divided in two groups, one submitted to low-intensity laser prophylaxis therapy after infusion of MTX and another group not submitted to prophylactic therapy. Results: The data obtained showed that preventive laser-therapy reduced the severity of oral mucositis with statistically significant results (p<0.001), corroborating the results found in the literature. Conclusion: The use of laser therapy is an important auxiliary therapy in the prevention and reduction of severity of oral mucositis in patients submitted to high doses of MTX, reducing the number of hospitalizations and delays in therapeutic protocol, which reduces costs and improves the patient prognosis.

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Published

2020-12-28

How to Cite

1.
Neves L de J, Boldrini Érica, Tanimoto HM, Trevisani DM, Lopes LF, Macari KSM. Evaluation of the Effect of Preventive Laser on Chemo-induced Oral Mucositis in Patients Submitted to High Doses of Methotrexate. Rev. Bras. Cancerol. [Internet]. 2020 Dec. 28 [cited 2024 Dec. 24];67(1):e-041128. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/1128

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Section

ORIGINAL ARTICLE

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