Scrambler Therapy for the Management of Chronic Oncologic Pain: Integrative Literature Review

Authors

  • Laura Ferreira de Rezende Centro Universitário das Faculdades Associadas de Ensino (Unifae), Curso de Fisioterapia. São João da Boa Vista (SP), Brasil. https://orcid.org/0000-0002-3714-1558
  • Vanessa Fonseca Vilas Boas Centro Universitário das Faculdades Associadas de Ensino (Unifae), Curso de Fisioterapia. São João da Boa Vista (SP), Brasil. https://orcid.org/0000-0002-0675-4781
  • Regiane Luz Carvalho Centro Universitário das Faculdades Associadas de Ensino (Unifae), Curso de Fisioterapia. São João da Boa Vista (SP), Brasil. https://orcid.org/0000-0003-2948-8903
  • Juliana Lenzi Universidade Estadual de Campinas (Unicamp). Campinas (SP), Brasil. https://orcid.org/0000-0002-9454-0440

DOI:

https://doi.org/10.32635/2176-9745.RBC.2022v68n1.1656

Keywords:

neoplasms, transcutaneous electric nerve stimulation, pain management, cancer pain/therapy, chronic pain

Abstract

Introduction: Scrambler therapy is a novel, non-invasive pain modifying technique that utilizes transcutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways. Objective: Evaluate the benefits of Scrambler therapy to manage the intensity of pain in oncologic patients. Method: Integrative literature review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in the electronic databases LILACS, PEDro, SciELO and PubMed. The descriptors “Scrambler therapy”, “cancer”, “pain” were randomly combined in addition to the Boolean operators AND, OR in Portuguese, English and Spanish with no time limitation. Results: For this review, 15 articles were found relevant. The Scrambler therapy machine is based on 5 artificial neurons controlled by an optimized algorithm to provide safety and effectiveness. The hardware receives information from the algorithm that creates the strings of “non-pain,” and processes them by transforming into potential flows of synthetic action (i.e. created by technology) functionally compatible with endogenous flows. Pain scrambler therapy had a potential to decrease pain in cancer patients. Conclusion: The positive findings from preliminary studies with Scrambler therapy endorses the benefits this device provides to manage oncologic pain.

Downloads

Download data is not yet available.

References

Neufeld NJ, Elnahal SM, Alvarez RH. Cancer pain: a review of epidemiology, clinical quality and value impact. Future Oncol. 2017;13(9):833-41. doi: https://doi.org/10.2217/fon-2016-0423 DOI: https://doi.org/10.2217/fon-2016-0423

Marineo G. Inside the Scrambler therapy, a noninvasive treatment of chronic neuropathic and cancer pain: from the gate control theory to the active principle of information. Integr Cancer Ther. 2019;18:1534735419845143. doi: https://doi.org/10.1177/1534735419845143 DOI: https://doi.org/10.1177/1534735419845143

Marineo G. Untreatable pain resulting from abdominal cancer: new hope from biophysics? JOP. 2003;4(1):1-10. Cited in: PubMed; PMID: 12555009.

Sabato AF, Marineo G, Gatti A. Scrambler therapy. Minerva Anestesiol. 2005;71(7-8):479-82. Cited in: PubMed; PMID: 16012423.

Lee JS. Efficacy of Scrambler therapy on breast cancer-related lymphedema. J Phys Ther Sci. 2018;30(11):1370-1. doi: https://doi.org/10.1589/jpts.30.1370 DOI: https://doi.org/10.1589/jpts.30.1370

Smith T, Cheville AL, Loprinzi CL, et al. Scrambler therapy for the treatment of chronic post-mastectomy pain (cPMP). Cureus. 2017;9(6):e1378. doi: https://doi.org/10.7759/cureus.1378 DOI: https://doi.org/10.7759/cureus.1378

Tomasello C, Pinto RM, Mennini C, et al. Scrambler therapy efficacy and safety for neuropathic pain correlated with chemotherapy-induced peripheral neuropathy in adolescents: a preliminary study. Pediatr Blood Cancer. 2018;65(7):e27064. doi: https://doi.org/10.1002/pbc.27064 DOI: https://doi.org/10.1002/pbc.27064

Notaro P, Dell'Agnola CA, Dell'Agnola AJ, et al. Pilot evaluation of Scrambler therapy for pain induced by bone and visceral metastases and refractory to standard therapies. Support Care Cancer. 2016;24(4):1649-54. doi: https://doi.org/10.1007/s00520-015-2952-x DOI: https://doi.org/10.1007/s00520-015-2952-x

Pachman DR, Weisbrod BL, Seisler DK, et al. Pilot evaluation of Scrambler therapy for the treatment of chemotherapy-induced peripheral neuropathy. Support Care Cancer. 2015;23(4):943-51. doi: https://doi.org/10.1007/s00520-014-2424-8 DOI: https://doi.org/10.1007/s00520-014-2424-8

Kashyap K, Joshi S, Vig S, et al. Impact of Scrambler therapy on pain management and quality of life in cancer patients: a study of twenty cases. Indian J Palliat Care. 2017;23(1):18-23. doi: https://doi.org/10.4103/0973-1075.197948 DOI: https://doi.org/10.4103/0973-1075.197948

Loprinzi C, Le-Rademacher JG, Majithia N, et al. Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial. Support Care Cancer. 2020;28(3):1183-97. doi: https://doi.org/10.1007/s00520-019-04881-3 DOI: https://doi.org/10.1007/s00520-019-04881-3

Park HS, Kim WJ, Kim HG, et al. Scrambler therapy for the treatment of neuropathic pain related to leukemia in a pediatric patient: a case report. Medicine (Baltimore). 2017;96(45):e8629. doi: https://doi.org/10.1097/MD.0000000000008629 DOI: https://doi.org/10.1097/MD.0000000000008629

Lee SC, Park KS, Moon JY, et al. An exploratory study on the effectiveness of "Calmare therapy" in patients with cancer-related neuropathic pain: a pilot study. Eur J Oncol Nurs. 2016;21:1-7. doi: https://doi.org/10.1016/j.ejon.2015.12.001 DOI: https://doi.org/10.1016/j.ejon.2015.12.001

Coyne PJ, Wan W, Dodson P, et al. A trial of Scrambler therapy in the treatment of cancer pain syndromes and chronic chemotherapy-induced peripheral neuropathy. J Pain Palliat Care Pharmacother. 2013;27(4):359-64. doi: https://doi.org/10.3109/15360288.2013.847519 DOI: https://doi.org/10.3109/15360288.2013.847519

Ricci M, Fabbri L, Pirotti S, et al. Scrambler therapy: what's new after 15 years? The results from 219 patients treated for chronic pain. Medicine (Baltimore). 2019;98(2):e13895. doi: https://doi.org/10.1097/MD.0000000000013895 DOI: https://doi.org/10.1097/MD.0000000000013895

Kashyap K, Singh V, Mishra S, et al. The efficacy of Scrambler therapy for the management of head, neck and thoracic cancer pain: a randomized controlled trial. Pain Physician. 2020;23(5):495-506. Cited in: PubMed; PMID: 32967392. DOI: https://doi.org/10.36076/ppj.2020/23/495

Smith TJ, Coyne PJ, Parker GL, et al. Pilot trial of a patient-specific cutaneous electrostimulation device (MC5-A Calmare®) for chemotherapy-induced peripheral neuropathy. J Pain Symptom Manage. 2010;40(6):883-91. doi: https://doi.org/10.1016/j.jpainsymman.2010.03.022 DOI: https://doi.org/10.1016/j.jpainsymman.2010.03.022

Childs DS, Le-Rademacher JG, McMurray R, et al. Randomized trial of Scrambler therapy for chemotherapy-induced peripheral neuropathy: crossover analysis. J Pain Symptom Manage. 2021;61(6):1247-53. doi: https://doi.org/10.1016/j.jpainsymman.2020.11.025 DOI: https://doi.org/10.1016/j.jpainsymman.2020.11.025

Majithia N, Smith TJ, Coyne PJ, et al. Scrambler therapy for the management of chronic pain. Support Care Cancer. 2016;24(6):2807-14. doi: https://doi.org/10.1007/s00520-016-3177-3 DOI: https://doi.org/10.1007/s00520-016-3177-3

Starkweather AR, Coyne P, Lyon DE, et al. Decreased low back pain intensity and differential gene expression following calmare®: results from a double-blinded randomized sham-controlled study. Res Nurs Health. 2015;38(1):29-38. doi: https://doi.org/10.1002/nur.21632 DOI: https://doi.org/10.1002/nur.21632

Ghatak RK, Nandi SN, Bhakta A, et al. Prospective study of application of biological communication (cybernatics) in management of chronic low back pain--a preliminary report. Nepal Med Coll J. 2011;13(4):257-60. Cited in: PubMed; PMID: 23016475.

Smith TJ, Marineo G. Treatment of postherpetic pain with Scrambler therapy, a patient-specific neurocutaneous electrical stimulation device. Am J Hosp Palliat Care. 2018;35(5):812-3. doi: https://doi.org/10.1177/1049909113494002 DOI: https://doi.org/10.1177/1049909113494002

Moon JY, Kurihara C, Beckles JP, et al. Predictive factors associated with success and failure for calmare (Scrambler) therapy: a multicenter analysis. Clin J Pain. 2014;31:750-56. doi: https://doi.org/10.1097/AJP.0000000000000155 DOI: https://doi.org/10.1097/AJP.0000000000000155

Published

2022-03-11

How to Cite

1.
Rezende LF de, Vilas Boas VF, Carvalho RL, Lenzi J. Scrambler Therapy for the Management of Chronic Oncologic Pain: Integrative Literature Review. Rev. Bras. Cancerol. [Internet]. 2022 Mar. 11 [cited 2024 Nov. 24];68(1):e-191656. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/1656

Issue

Section

LITERATURE REVIEW