BRCA Genes Contribution in the hereditary predisposition for breast cancer

Authors

  • Luis Cláudio Belo Amendola Mestre em Saúde da Criança e da Mulher - Instituto Fernandes Figueira - FIOCRUZ, Coordenador Administrativo do Projeto Câncer de Mama e Genética - FIOCRUZ, Especialista em Mastologia - SBM, Especialista em Ginecologia e Obstetrícia
  • Roberto Vieira Mestre e Doutor - Instituto Fernandes Figueira - FIOCRUZ, Pesquisador e Professor da Pós-Graduação do IFF, Chefe do Serviço de Mastologia do IFF - FIOCRUZ Coordenador do Projeto Câncer de Mama e Genética

DOI:

https://doi.org/10.32635/2176-9745.RBC.2005v51n4.1927

Keywords:

Breast neoplasms, Genetic, BRCA genes

Abstract

Approximately 20% of the cases related to familiar breast cancer are associated to one gene of hereditary susceptibility for breast and ovarian cancer, BRCA1 and BRCA2. Recent works have demonstrated the mechanism of action of these genes, with functions well established for maintaining the genome integrity and for controlling homologates recombination. Familiar history, bilaterality, precocious diseases, as well as specific histopathologic results are indicative factors of the presence of mutation in these genes. This literature review summarizes some of this knowledge, trying to understand them in the current functional context of these genes.

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Published

2005-12-30

How to Cite

1.
Amendola LCB, Vieira R. BRCA Genes Contribution in the hereditary predisposition for breast cancer. Rev. Bras. Cancerol. [Internet]. 2005 Dec. 30 [cited 2024 May 20];51(4):325-30. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/1927

Issue

Vol. 51 No. 4 (2005): Oct./Nov./Dec.

Section

LITERATURE REVIEW