Cleft Lip/Palate and Cancer: a True Connection

Authors

  • Alexandre Rezende Vieira University of Pittsburgh, School of Dental Medicine, Department of Oral & Craniofacial Sciences. Pittsburgh, PA, USA. https://orcid.org/0000-0003-3392-6881

DOI:

https://doi.org/10.32635/2176-9745.RBC.2021v67n4.2396

Keywords:

Cleft Lip, Cleft Palate, Neoplasms

Abstract

Multifactorial cleft lip and palate is relatively common in populations (1 in every 700 livebirths). Individuals born with clefts require lifelong treatment after initial surgical repair and data suggested that their lifespan is shorter, possibly due to cancer or psychiatric conditions. Molecular defects that alter facial development in utero appear to later in life predispose to cancer. Common polymorphisms in e-cadherin and an endoplasmic reticulum transmembrane sensor gene appear to hold the promise to be biomarkers that may help to define individual risks to cancer, in the presence or not of family history of clefts.

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Published

2021-09-29

How to Cite

1.
Vieira AR. Cleft Lip/Palate and Cancer: a True Connection. Rev. Bras. Cancerol. [Internet]. 2021 Sep. 29 [cited 2024 Jul. 22];67(4):e-062396. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/2396

Issue

Vol. 67 No. 4 (2021): Oct./Nov./Dec.

Section

OPINION

License

Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.