Parotid carcinoma concomitant with breast carcinoma: case report
DOI:
https://doi.org/10.32635/2176-9745.RBC.1999v45n2.2775Keywords:
Salivary Gland Neoplasms, Breast NeoplasmsAbstract
The risk of development of breast cancer in patients that present salivary gland tumors has been discussed since 1968. However, it was not found a common causal factor, responsible for this association. The authors report a case of papillary parotid adenocarcinoma on the right side in an 85 year-oldpatient, who also had a concomitant ductal invasive breast carcinoma in the same side as the parotid neoplasm. Clinically, there was information of malignancy in both lesions, in the parotid and in the breast. The diagnosis was confirmed by citology of the parotid tumor and histology (biopsy) of the breast cancer. The initial idea was to perform a parotidectomy plus modified unilateral cervical dissection and mastectomy for the breast cancer. The patient has refused to the mastectomy procedure. She has only accepted surgery of the parotid gland. Total parotidectomy plus modified cervical dissection were performed and postoperatory radiotherapy and tamoxifen were used for the breast disead. There was a satisfactory response of the breast cancer, with consequent decrease of the disease. One year after the first surgery there was a recurrence of adenocarcinoma in the right parotid region. On this occasion, a new ressection of tumors was performed. It was done a classic neck dissection and deltoyd-great myocutaneos flap reconstruction. It was necessary this kind of reconstruction because there was tumor in the skin. Presently the patient been followed up at the outpatient clinic, without signs of local recurrence. The present case points at a possible relation to pre-existing factors that many exist, to justijy the tumors, according to authors mentioned in the literature. In a salivary gland tumor study with 521 patients (154 men and 367 women), 8 patients presented concomitant breast cancer (I men and 7 women), showing a relative risk ofl,3 (p<0,005). There is evidence of the influence of endogenous hormones in salivary gland tumor and breast cancer as well as in other tumors. Other authors mention chromossomic alterations associated to this tumors.
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References
BERG, J.W.; HUTTER, R.V.P.; FOOTE, F.W. - The unique association between salivary gland câncer and breast câncer. JAMA, 1968, 204(9):771-774. DOI: https://doi.org/10.1001/jama.204.9.771
STANDFAST, S.J. - Salivary gland câncer and breast câncer. JAMA, 1968,205(8); 125. DOI: https://doi.org/10.1001/jama.1968.03140340067025
MOERTEL, C.G.; ELVEBACK, L.R. – The association between salivary gland câncer and breast câncer. JAMA, 1969, 210(2):306-308. DOI: https://doi.org/10.1001/jama.210.2.306
DUNN, J.E.Jr.; BRAGG, K.U.; SAUTTER, C.et al - Breast câncer risk following a major salivary gland carcinoma. Câncer, 1972, 29:1343. DOI: https://doi.org/10.1002/1097-0142(197205)29:5<1343::AID-CNCR2820290532>3.0.CO;2-Y
PRIOR, R; WATERHOUSE, J. A.H. – Second primary cancers in patients with tumours of the salivary glands. Br.J.Câncer, 1997, 36:362. DOI: https://doi.org/10.1038/bjc.1977.201
BIGGAR, R.J.; CURTIS, R.E.; HOFFMAN, D. A. - Second primary malignances following salivary gland cancers. BrJ.Cancer, 1983,47:383-386. DOI: https://doi.org/10.1038/bjc.1983.57
ARMSTRONG, B. - Endocrine factors in human carcinogenesis. lARC Sei Publ, 1982,39:193-221.
TOOHILL R.J.; LEHMAN R.H.; GROSSMAN T.W. - Adenoid eystie carcinoma of the submaxillary gland. Laryngoscope, 1982, 92:497-501. DOI: https://doi.org/10.1288/00005537-198205000-00007
AFIFY, A.; BLAND, K. I.; MARK, H. F. - Fluorescent in situ hybridization assessment of chromosome 8 copy number in breast câncer. Breast Câncer Res Treat, 1996, 38(2);201-208 DOI: https://doi.org/10.1007/BF01806674
