O Tratamento de Infecções por Bacilos Gram-Negativos em Pacientes Imunossuprimidos
DOI:
https://doi.org/10.32635/2176-9745.RBC.1985v31n2.3322Keywords:
Infection in Immunesupressed Patients, Hospitalar Infection, Cram Negative InfectionsAbstract
Some aspects of the epidemiologic control and treatment of gram-negative rods infections in imunossupressed patients are discussed. Potent new antimicrobial chemotherapy has been developed, with agents of the B-lactam and aminoglycoside class. in spite of these developments, the likelyhood of drug resistance seems great. Presently, much attention has been paid to host defenses. Replacement or supplementation of circulating fagocitic cells has encountered major technical problems and complications. Development of monoclonal anti-bodies and intravenous imunoglobulin must be tested as a new benefit for the patient.
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References
Armstrong D.; Young L. S.; Meyer R. D.; Blevins A. H.: Infectious complications of neoplastic diseases. Med. Clin. North. Am., 55: 729, 1971. DOI: https://doi.org/10.1016/S0025-7125(16)32514-7
Bermudez L. E.; Velasco E.: Comparação da eficácia de seis regimes de antibióticos em pacientes granulocitopênicos com febre. Submetido à publicação, 1984.
Lau W. K.; Young L. S.; Black R. E.; Wiston, D. J.; et al.: Comparativa efficacy and toxicity of amikacin/carbenicilin versus gentamicin/carbenicilin in leukopenic patients. Am. J. Med., 62: 959, 1977. DOI: https://doi.org/10.1016/0002-9343(77)90669-6
Angus, B. L.; Caey, A. M.; Caron, D. A.; et al.: Outer membrana permeability in Pseudomonas aeruginosa: comparison of a wild type with an antibiotic-susceptible mutant. Anti-micr. Agents Chemother, 21: 299, 1982. DOI: https://doi.org/10.1128/AAC.21.2.299
Sanders, C. C.: Novel resistance selected by the new expanded-spectrum cephalosporins: a concern. J. Infect. Dis., 147: 585, 1983. DOI: https://doi.org/10.1093/infdis/147.3.585
Sanders, C. C.; Sanders, W. E.: Emergence of resistance during therapy with the newer beta-lactam antibiotics. Rev. Infect. Dis., 5:639, 1983. DOI: https://doi.org/10.1093/clinids/5.4.639
Bermudez, L. E,; Pereira Dias, L. M.; Braz Neto, E,; Vidal, E.: Evidência in vitro da produção de Beta-lactamase por bactérias isoladas em um Hospital de Câncer. Submetido á publicação. 1984.
Singer, C.; Kaplan, M. H.; Armstrong, D.: Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am. J. Med., 62: 731, 1977. DOI: https://doi.org/10.1016/0002-9343(77)90876-2
Bermudez, L. E.: Infecções hospitalares em pacientes com câncer. In: Infecções Hospitalares, Uriel Zanon (ed); In press.
Roy, C.; Foz, A.; Segura, C.; et al.: Plasmid mediated beta-lactamases identified in a group of 204 ampicilin-resistant Enterobacteriaceae. J. Antimicr. Chemother., 12: 507, 1983. DOI: https://doi.org/10.1093/jac/12.5.507
Seeberg, A. H.; Tolxdorff, R. M.; Wiedemann, B.: Chromossomal B-lactamases of Enterobacter cloacae are responsible by resistance to third generation cephalosporins. Antimicrob. Agents. Chemother., 23: 918, 1983. DOI: https://doi.org/10.1128/AAC.23.6.918
Pennington, J.; Ehrie, M.; Hicrey, W.: Host defense mechanisms against pneumonia due to Pseudomonas aeruginosa. Reviews Infect Dis., 653: 5657, 1984. DOI: https://doi.org/10.1093/clinids/6.Supplement_3.S657
Sickers, E. A.; Young, V. M.; Greene, W. H.: Pneumonia in acute leukemia. Ann Intern Med, 79: 528, 1973. DOI: https://doi.org/10.7326/0003-4819-79-4-528
Zregler, E.; Mc Cutchan, A.; Fierer, J.; et al.: Treatment of gram-negative bactéria and shock with human antiserum to a mutant E. coll. N Engl. J. Med., 307: 1225, 1982. DOI: https://doi.org/10.1056/NEJM198211113072001
