Influence of Age on Health-Related Quality of Life of Women Diagnosed with Breast Cancer
DOI:
https://doi.org/10.32635/2176-9745.RBC.2023v69n2.3826Keywords:
breast neoplasms, quality of life, surveys and questionnaires, age factorsAbstract
Introduction: Women with breast cancer may have differences in health-related quality of life (HRQoL) at diagnosis by age. Objective: To analyze the influence of age on the HRQoL of women diagnosed with breast cancer. Method: Cross-sectional study was carried out with women diagnosed with breast cancer. HRQoL assessment was performed before starting cancer treatment, using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its specific breast cancer module (BR-23). Association between age group and HRQoL was determined through multiple linear regression. Results: 961 women were included in the study, with a mean age of 54 (SD±11.7). Women aged ≥50 years displayed better emotional functioning (+7.6 points; p<0.001), and less fatigue (-4.4 points; p=0.014), pain (-4.7 points; p=0.033), nausea and vomiting (-2.3 points; p=0.030) and financial difficulties (-10.3 points; p<0.001) compared to younger women. Concerning the BR-23 module, these women displayed better body image scores (+3.6 points; p=0.029) and future perspective (+12.4 points; p<0.001), and worse sexual functioning (-19.9 points; p<0.001) and sexual enjoyment (-8.9 points; p=0.001), and on the symptom scale, less breast symptoms (-11.6 points; p<0.001) and arm symptoms (-3.5 points; p=0.047). Conclusion: Patients aged ≥50 years exhibited better HRQoL in all QLQ C-30 and BR-23 functioning scales and symptom scales, except for sexual functioning and sexual enjoyment.
Downloads
References
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. doi: https://doi.org/10.3322/caac.21660 DOI: https://doi.org/10.3322/caac.21660
Tsaras K, Papathanasiou IV, Mitsi D, et al. Assessment of depression and anxiety in breast cancer patients: prevalence and associated factors. Asian Pac J Cancer Prev. 2018;19(6):1661-69. doi: https://doi.org/10.22034/APJCP.2018.19.6.1661
Brunault P, Champagne AL, Huguet G, et al. Major depressive disorder, personality disorders, and coping strategies are independent risk factors for lower quality of life in non-metastatic breast cancer patients. Psychooncology. 2016;25(5):513-20. doi: https://doi.org/10.1002/pon.3947 DOI: https://doi.org/10.1002/pon.3947
Gold M, Dunn LB, Phoenix B, et al. Co-occurrence of anxiety and depressive symptoms following breast cancer surgery and its impact on quality of life. Eur J Oncol Nurs. 2016;20:97-105. doi: https://doi.org/10.1016/j.ejon.2015.06.003 DOI: https://doi.org/10.1016/j.ejon.2015.06.003
Cho YU, Lee BG, Kim SH. Coping style at diagnosis and its association with subsequent health-related quality of life in women with breast cancer: a 3-year follow-up study. Eur J Oncol Nurs. 2020;45:101726. doi: https://doi.org/10.1016/j.ejon.2020.101726 DOI: https://doi.org/10.1016/j.ejon.2020.101726
De Aguiar SS, Bergmann A, Mattos IE. Quality of life as a predictor of overall survival after breast cancer treatment. Qual Life Res. 2014;23(2):627-37. doi: https://doi.org/10.1007/s11136-013-0476-8 DOI: https://doi.org/10.1007/s11136-013-0476-8
Karlsen RV, Frederiksen K, Larsen MB, et al. The impact of a breast cancer diagnosis on health-related quality of life. A prospective comparison among middle-aged to elderly women with and without breast cancer. Acta Oncol. 2016;55(6):720-7. doi: https://doi.org/10.3109/0284186X.2015.1127415 DOI: https://doi.org/10.3109/0284186X.2015.1127415
Mierzynska J, Taye M, Pe M, et al. Reference values for the EORTC QLQ-C30 in early and metastatic breast cancer. Eur J Cancer. 2020;125:69-82. doi: https://doi.org/10.1016/J.Ejca.2019.10.031 DOI: https://doi.org/10.1016/j.ejca.2019.10.031
Sitlinger A, Zafar SY. Health-related quality of life: the impact on morbidity and mortality. Surg Oncol Clin N Am. 2018;27(4):675-84. doi: https://doi.org/10.1016/j.soc.2018.05.008 DOI: https://doi.org/10.1016/j.soc.2018.05.008
Sinha R, Coyle C, Ring A. Breast cancer in older patients: national cancer registry data. Int J Clin Pract. 2013;67(7):698-700. doi: https://doi.org/10.1111/ijcp.12117 DOI: https://doi.org/10.1111/ijcp.12117
Park JH, Jung YS, Kim JY, et al. Trajectories of health-related quality of life in breast cancer patients. Support Care Cancer. 2020;28(7):3381-9. doi: https://doi.org/10.1007/s00520-019-05184-3 DOI: https://doi.org/10.1007/s00520-019-05184-3
Tejeda S, Stolley MR, Vijayasiri G, et al. Negative psychological consequences of breast cancer among recently diagnosed ethnically diverse women. Psychooncology. 2017;26(12):2245-52. doi: https://doi.org/10.1002/pon.4456 DOI: https://doi.org/10.1002/pon.4456
Champion VL, Wagner LI, Monahan PO, et al. Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains. Cancer. 2014;120(15):2237-46. doi: https://doi.org/10.1002/cncr.28737 DOI: https://doi.org/10.1002/cncr.28737
Wöckel A, Schwentner L, Krockenberger M, et al. Predictors of the course of quality of life during therapy in women with primary breast cancer. Qual Life Res. 2017;26(8):2201-8. doi: https://doi.org/10.1007/s11136-017-1570-0 DOI: https://doi.org/10.1007/s11136-017-1570-0
Assogba ELF, Kamga AM, Costaz H, et al. What are young women living conditions after breast cancer? Health-related quality of life, sexual and fertility issues, professional reinsertion. Cancers (Basel). 2020;12(6):1564. doi: https://doi.org/10.3390/cancers12061564 DOI: https://doi.org/10.3390/cancers12061564
Michels FAS, Latorre MR, Maciel MS. Validity, reliability and understanding of the EORTC-C30 and EORTC-BR23, quality of life questionnaires specific for breast cancer. Rev Bras Epidemiol. 2013;16(2):352-63. doi: https://doi.org/10.1590/S1415-790X2013000200011 DOI: https://doi.org/10.1590/S1415-790X2013000200011
Fayers P, Bottomley A; EORTC Quality of Life Group, et al. Quality of life research within the EORTC-the EORTC QLQ-C30. Eur J Cancer. 2002;38(Suppl 4):S125-33. doi: https://doi.org/10.1016/s0959-8049(01)00448-8 DOI: https://doi.org/10.1016/S0959-8049(01)00448-8
Conselho Nacional de Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção 1:59.
Tran TH, Trinh NL, Hoang Y, et al. Health-related quality of life among vietnamese breast cancer women. Cancer Control. 2019;26(1):1073274819862787. doi: https://doi.org/10.1177/1073274819862787 DOI: https://doi.org/10.1177/1073274819862787
Hamer J, McDonald R, Zhang L, et al. Quality of life (QOL) and symptom burden (SB) in patients with breast cancer. Support Care Cancer. 2017;25(2):409-19. doi: https://doi.org/10.1007/s00520-016-3417-6 DOI: https://doi.org/10.1007/s00520-016-3417-6
Pinheiro LC, Tan X, Olshan AF, et al. Examining health-related quality of life patterns in women with breast cancer. Qual Life Res. 2017;26(7):1733-43. doi: https://doi.org/10.1007/s11136-017-1533-5 DOI: https://doi.org/10.1007/s11136-017-1533-5
Howard-Anderson J, Ganz PA, Bower JE, et al. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(5):386-405. doi: https://doi.org/10.1093/jnci/djr541 DOI: https://doi.org/10.1093/jnci/djr541
Leinert E, Singer S, Janni W, et al. The impact of age on quality of life in breast cancer patients receiving adjuvant chemotherapy: a comparative analysis from the prospective multicenter randomized ADEBAR trial. Clin Breast Cancer. 2017;17(2):100-6. doi: https://doi.org/10.1016/j.clbc.2016.10.008 DOI: https://doi.org/10.1016/j.clbc.2016.10.008
Dialla PO, Chu WO, Roignot P, et al. Impact of age-related socio-economic and clinical determinants of quality of life among long-term breast cancer survivors. Maturitas. 2015;81(3):362-70. doi: https://doi.org/10.1016/j.maturitas.2015.03.025 DOI: https://doi.org/10.1016/j.maturitas.2015.03.025
Franzoi MA, Rosa DD, Zaffaroni F, et al. Advanced stage at diagnosis and worse clinicopathologic features in young women with breast cancer in Brazil: a subanalysis of the AMAZONA III study (GBECAM 0115). J Glob Oncol. 2019;5:1-10. doi: https://doi.org/10.1200/JGO.19.00263 DOI: https://doi.org/10.1200/JGO.19.00263
Imran M, Al-Wassia R, Alkhayyat SS, et al. Assessment of quality of life (QoL) in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires: a tertiary care center survey in the western region of Saudi Arabia. PLoS One. 2019;14(7):e0219093. doi: https://doi.org/10.1371/journal.pone.0219093 DOI: https://doi.org/10.1371/journal.pone.0219093
Fobair P, Spiegel D. Concerns about sexuality after breast cancer. Cancer J. 2009;15(1):19-26. doi: https://doi.org/10.1097/PPO.0b013e31819587bb DOI: https://doi.org/10.1097/PPO.0b013e31819587bb
Published
How to Cite
Issue
Section
License
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
This work is licensed under a Creative Commons Attribution 4.0 International License.