Observações sobre o Desenvolvimento de Fibrossarcoma Transplantado em Gerbil (Meriones Unguiculatus)
DOI:
https://doi.org/10.32635/2176-9745.RBC.1989v35n3/4.4279Keywords:
Transplantation, Fibrosarcoma, GerbilAbstract
The authors report the study of a chemically induced and transplantable fibrosarcoma in the gerbil. This tumor was mantained by successive intraperitoneal passages using tumor cell suspension in association or not with mineral oil. The incidence, latencyperiod, growth pattern and host response were determined after subcutaneous implantation of 1 x 10F tumor cells. The latency period was significantly lower in animal receiving cell suspension derived from donors treated with mineral oil. Nevertheless incidence and overall tumor growth was similar in both groups. The kinetic analysis of tumor growth, showed an initial exponencial proliferative phase, with a tendency to convex upwards. This was also demonstreated by an increasing duplication time of the tumor area. Gerbils bearing subeutaneous fibrosarcoma lost body weight during the experimental period. Tumor weight showed a significative linear relationship with tumor area, and at least for this tumor, an estimation of tumor weight might be obtained from externai measurements of the area.
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