Incidental Gallbladder Cancer: Statistical Overview in a Tertiary Hospital in Fortaleza, CE, Brazil

Authors

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n1.4503

Keywords:

Gallbladder Diseases/epidemiology, Gallbladder Neoplasms/epidemiology, Cholecystolithiasis/surgery, Cholecystectomy

Abstract

Introduction: Gallbladder adenocarcinoma is the most common malignant tumor of the bile ducts and is sometimes discovered incidentally after cholecystectomy for benign gallbladder disease. Objective: To determine the prevalence and describe epidemiological aspects observed in patients diagnosed with incidental gallbladder cancer (IBC) in cholecystectomies performed between 2015 and 2022 at the Walter Cantídio University Hospital. Method: Descriptive cross-sectional study, with retrospective data where all medical records of patients undergoing elective and non-elective cholecystectomy in a high-complexity public hospital in Fortaleza, between January 2015 and December 2022, were included. The exclusion criteria were all patients who underwent cholecystectomy and had an established or presumed diagnosis of gallbladder neoplasia. Results: During the study period, 1,707 patients who underwent cholecystectomy with a diagnosis of cholelithiasis or cholecystitis have been found, 382 anatomopathological reports were lost and six patients with a previous diagnosis of gallbladder neoplasia were excluded, totaling 1,319 patients. Of these, nine (0.7%) were incidentally diagnosed with gallbladder adenocarcinoma after anatomopathological study. Conclusion: Corroborating the global literature, the prevalence of IBC in the present study was low and occurred more frequently in older female patients than those affected by benign bile duct disease.

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References

Torres OJM, Alikhanov R, Agarwal A, et al. Consenso brasileiro de carcinoma incidental de vesícula biliar. ABCD. Arq Bras Cir Dig. 2020;33(1):e1496. doi: https://doi.org/10.1590/0102-672020190001e1496 DOI: https://doi.org/10.1590/0102-672020190001e1496

Geramizadeh B, Kashkooe A. Incidental gall bladder adenocarcinoma in cholecystectomy specimens; a single center experience and review of the literature. Middle East J Dig Dis. 2018;10(4):249-53. doi: https://doi.org/10.15171/mejdd.2018.118 DOI: https://doi.org/10.15171/mejdd.2018.118

Silva DAG, Veloso OLL, Valadares MSP, et al. Câncer incidental de vesícula biliar: qual a prevalência e como operamos a colecistectomia por doença presumidamente benigna? Rev Col Bras Cir. 2022;49:e20223417. doi: https://doi.org/10.1590/0100-6991e-20223417 DOI: https://doi.org/10.1590/0100-6991e-20223417

Kanlioz M, Ekici U, Ayva Y. Analysis of incidental gallbladder cancer in cholecystectomies. Cureus. 2019;11(9):e5710. doi: https://doi.org/10.7759/cureus.5710 DOI: https://doi.org/10.7759/cureus.5710

Mehrotra B. Gallbladder cancer: epidemiology, risk factors, clinical features, and diagnosis. UpTodate [Internet]. 2022[acesso 2023 set 1];1:1. Disponível em: https://www.uptodate.com/contents/gallbladder-cancer-epidemiology-risk-factors-clinical-features-and-diagnosis/print?search=cancer%20de%20vesicula&source=search_result&selectedTitle=1~62&usage_type=default&display_rank=1

House MG, Mehrotra B. Surgical management of gallbladder cancer. UpTodate [Internet]. 2021;1:1. [acesso 2023 set 3]. Disponível em: https://www.uptodate.com/contents/surgical-management-of-gallbladder-cancer?search=cancer%20de%20vesicula&source=search_result&selectedTitle=2~62&usage_type=default&display_rank=2

Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.

Figueiredo WR, Santos RR, Paula MMDRC. Comparative incidence of incidental gallbladder cancer in emergency cholecystectomies versus in elective cholecystectomies. Incidência comparativa de câncer incidental de vesícula biliar em colecistectomias de urgência versus colecistectomias eletivas. Rev Col Bras Cir. 2019;46(6):e20192366. doi: https://doi.org/10.1590/0100-6991e-20192366 DOI: https://doi.org/10.1590/0100-6991e-20192366

Martins-Filho ED, Batista TP, Kreimer F, et al. Prevalence of incidental gallbladder cancer in a tertiary-care hospital from Pernambuco, Brazil. Arq Gastroenterol. 2015;52(3):247-9. doi: https://doi.org/10.1590/S0004-28032015000300017 DOI: https://doi.org/10.1590/S0004-28032015000300017

Di Mauro D, Orabi A, Myintmo A, et al. Routine examination of gallbladder specimens after cholecystectomy: a single-centre analysis of the incidence, clinical and histopathological aspects of incidental gallbladder carcinoma. Discov Oncol. 2021;12(4):1-7. doi https://doi.org/10.1007/s12672-021-00399-5 DOI: https://doi.org/10.1007/s12672-021-00399-5

Apodaca-Rueda M, Cazzo E, De-Carvalho RB, et al. PREVALENCE of gallbladder cancer in patients submitted to cholecystectomy: experience of the university hospital, faculty of medical sciences, State University of Campinas – UNICAMP. Rev Col Bras Cir. 2017;44(3):252-6. doi: https://doi.org/10.1590/0100-69912017003005 DOI: https://doi.org/10.1590/0100-69912017003005

Ocón FJM, Vicente JB, Orts FR, et al. Cáncer de vesícula biliar en un hospital comarcal. Cirug Esp. 2009;86(4):219-23. doi: https://doi.org/10.1016/j.ciresp.2009.02.021 DOI: https://doi.org/10.1016/j.ciresp.2009.02.021

Yadav R, Sagar M, Kumar S, et al. Incidental gallbladder carcinoma in north Indian population: importance of routine histopathological examination of all benign gallbladder specimens. Cureus. 2021;13(7):e16156. doi: https://doi.org/10.7759/cureus.16156 DOI: https://doi.org/10.7759/cureus.16156

Published

2024-04-19

How to Cite

1.
Aguiar AAC de, Almeida AM, Gomes ACF, Pessoa MVN, Ponte IM da, Goes ACA de M, Costa MLV. Incidental Gallbladder Cancer: Statistical Overview in a Tertiary Hospital in Fortaleza, CE, Brazil. Rev. Bras. Cancerol. [Internet]. 2024 Apr. 19 [cited 2024 Jul. 3];70(1):e-204503. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/4503

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ORIGINAL ARTICLE

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