Factors Associated with Neuropathic Pain in Cancer Patients Admitted to a Palliative Care Unit

Authors

  • Patricia Almeida Chelles Instituto Nacional de Câncer (INCA), Unidade de Cuidados Paliativos. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0001-5687-0302
  • Livia Costa de Oliveira Instituto Nacional de Câncer (INCA), Unidade de Cuidados Paliativos. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0002-5052-1846
  • Luciana Silva Couto Instituto Nacional de Câncer (INCA), Unidade de Cuidados Paliativos. Rio de Janeiro (RJ), Brasil. https://orcid.org/0009-0006-2870-567X
  • Simone Garruth dos Santos Machado Sampaio Instituto Nacional de Câncer (INCA), Unidade de Cuidados Paliativos. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0001-5537-7399
  • Anke Bergmann Instituto Nacional de Câncer (INCA), Grupo de Pesquisa em Epidemiologia Clínica. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0002-1972-8777

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n2.4603

Keywords:

Cancer Pain, Hospitalization, Neoplasm Metastasis, Palliative Care

Abstract

Introduction: Recognizing factors associated with pain in advanced cancer patients may favor a better multidisciplinary approach. Objective: To identify factors associated with the most prevalent type of pain in cancer patients admitted to a palliative care unit. Method: Cohort-study-based cross-sectional analysis of baseline data collected from cancer inpatients at the palliative care unit assisted by the physiotherapy service. Sociodemographic, clinical data and pain characteristics were obtained and analyzed according to the most prevalent type of pain at hospital admission. An odds ratio (OR) logistic regression was utilized as a measure of effect at a 95% confidence
interval (95% CI). Results: A total of 62 patients were assessed, mostly women (69.3%) with less than 60 years old (67.7%), the most frequent tumor sites were gynecological (25.8%) and breast (16.1%). Local disease progression associated with metastasis was observed in 87.1% of all patients, with 50.0% presenting bone metastasis and 37.1%, a bone event. The most prevalent type was moderate to
severe (69.3%) neuropathic pain (51.6%), associated with the presence of a bone event (OR = 3.16; 95% CI: 1.01-9.90) and less than 60 years old (OR = 4.08; 95% CI: 1.91 -17.52). Conclusion: Neuropathic pain was the most prevalent pain in cancer patients receiving palliative care associated with the presence of bone events and less than 60 years old.

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References

Snijders RAH, Brom L, Theunissen M, et al. Update on prevalence of pain in patients with cancer 2022: a systematic literature review and meta-analysis. Cancers (Basel). 2023;15(3):591. doi: https://doi.org/10.3390/cancers15030591 DOI: https://doi.org/10.3390/cancers15030591

Mendes CMC, Machado DM, Linartevichi VF. Neuropathic index in oncological patients and pharmacological conduct. FJH. 2020;2(4):424-8. doi: https://doi.org/10.35984/fjh.v2i4.264 DOI: https://doi.org/10.35984/fjh.v2i4.264

Couceiro TCM, Lima LC, Coutinho Júnior MP, et al. Prevalence of neuropathic pain in patients with cancer. Br J Pain. 2018;1(3):231-5. doi: https://doi.org/10.5935/2595-0118.20180045 DOI: https://doi.org/10.5935/2595-0118.20180045

Zajączkowska R, Kocot-Kępska M, Leppert W, et al. Bone pain in cancer patients: mechanisms and current treatment. Int J Mol Sci. 2019;20(23):6047. doi: https://doi.org/10.3390/ijms20236047 DOI: https://doi.org/10.3390/ijms20236047

Associação Brasileira de Fisioterapia em Oncologia. Manual de Condutas e Práticas Fisioterapêuticas em Cuidados Paliativos Oncológicos da ABFO. Rio de Janeiro: Thiene Revinter Publicações; 2021.

Academia Nacional de Cuidados Paliativos. Manual de Cuidados Paliativos da ANCP. 3. ed. Rio de Janeiro: Atheneu; 2021.

Instituto Nacional De Câncer José Alencar Gomes da Silva. Cuidados paliativos: vivências e aplicações práticas do Hospital do Câncer IV [Internet]. Rio de Janeiro: INCA, 2021. [acesso 2023 jun 15]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//cuidados_paliativos-hciv.pdf

Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.

Malta MS, Cardoso LO, Bastos FIPM, et al. Iniciativa STROBE: subsídios para a comunicação de estudos observacionais. Rev Saúde Pública. 2010;44(3):559-65. DOI: https://doi.org/10.1590/S0034-89102010000300021

Finnerup NB, Haroutounian S, Kamerman P, et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016;157(8):1599-1606. doi: https://doi.org/10.1097/j.pain.0000000000000492 DOI: https://doi.org/10.1097/j.pain.0000000000000492

Fortunato JGS, Furtado MDS, Hirabae LFDA, et al. “Scales of pain in the critically ill patient: an integrative review”. Rev HUPE. 2013 [acesso 2023 jun 15];12(3):110. Disponível em: https://link.gale.com/apps/doc/A372554603/AONE?u=anon~e1184ef5&sid=googleScholar&xid=67c55fee

SPSS®: Statistical Package for Social Science (SPSS) [Internet]. Versão 20.0. [Nova York]. International Business Machines Corporation. [acesso 2024 jan 9]. Disponível em: https://www.ibm.com/br-pt/spss?utm_content=SRCWW&p1=Search&p4=43700077515785492&p5=p&gclid=CjwKCAjwgZCoBhBnEiwAz35Rwiltb7s14pOSLocnooMOQh9qAL59IHVc9WP4ixhNTVMjenRp3-aEgxoCubsQAvD_BwE&gclsrc=aw.ds

Satija A, Joad AK, Rana SPS, et al. The burden of cancerrelated neuropathic pain: a multi-centric cross-sectional observational study from North India. Indian J Palliat Care. 2021;27(1):104-08. doi: https://doi.org/10.4103/ijpc.ijpc_277_20 DOI: https://doi.org/10.4103/IJPC.IJPC_277_20

Roberto A, Deandrea S, Greco MT, et al. prevalence of neuropathic pain in cancer patients: pooled estimates from a systematic review of published literature and results from a survey conducted in 50 italian palliative care centers. J Pain Symptom Manage. 2016;51(6):1091-02.e4. doi: https://doi.org/10.1016/j.jpainsymman.2015.12.336 DOI: https://doi.org/10.1016/j.jpainsymman.2015.12.336

Yanaizumi R, Nagamine Y, Harada S, et al. Prevalence of neuropathic pain in terminally ill patients with cancer admitted to a general ward: a prospective observational study. J Int Med Res. 2021;49(1):300060520987726. doi: https://doi.org/10.1177/0300060520987726 DOI: https://doi.org/10.1177/0300060520987726

Belayneh M, Fainsinger R, Nekolaichuk C, et al. Edmonton classification system for cancer pain: comparison of pain classification features and pain intensity across diverse palliative care settings in canada. J Palliat Med. 2023;26(3):366-75. doi: https://doi.org/10.1089/jpm.2022.0187 DOI: https://doi.org/10.1089/jpm.2022.0187

Yoon SL, Scarton L, Duckworth L, et al. Pain, symptom distress, and pain barriers by age among patients with cancer receiving hospice care: comparison of baseline data. J Geriatr Oncol. 2021;12(7):1068-75. doi: https://doi.org/10.1016/j.jgo.2021.04.008 DOI: https://doi.org/10.1016/j.jgo.2021.04.008

Olden AM, Holloway R, Ladwig S, et al. Palliative care needs and symptom patterns of hospitalized elders referred for consultation. J Pain Symptom Manage. 2011;42(3):410-8. doi: https://doi.org/10.1016/j.jpainsymman.2010.12.005 DOI: https://doi.org/10.1016/j.jpainsymman.2010.12.005

Oosterling A, te Boveldt N, Verhagen C, et al. Neuropathic pain components in patients with cancer: prevalence, treatment, and interference with daily activities. Pain Pract. 2016;16(4):413-21. doi: https://doi.org/10.1111/papr.12291 DOI: https://doi.org/10.1111/papr.12291

Hansen MB, Ross L, Petersen MA, et al. Age, cancer site and gender associations with symptoms and problems in specialised palliative care: a large, nationwide, register-based study. BMJ Support Palliat Care. 2022;12(e2):e201-e210. doi: https://doi.org/10.1136/bmjspcare-2019-001880 DOI: https://doi.org/10.1136/bmjspcare-2019-001880

Sumimoto H, Hayashi K, Kimura Y, et al. Factors associated with cancer-related pain requiring high-dose opioid use in palliative cancer patients. Palliat Med Rep. 2021;2(1):237-41. doi: https://doi.org/10.1089/pmr.2021.0037 DOI: https://doi.org/10.1089/pmr.2021.0037

Tsukamoto S, Kido A, Tanaka Y, et al. Current overview of treatment for metastatic bone disease. Curr Oncol. 2021;28(5):3347-72. doi: https://doi.org/10.3390/curroncol28050290 DOI: https://doi.org/10.3390/curroncol28050290

Silva GT, Bergmann A, Thuler LCS. Incidence and risk factors for bone metastasis in non-small cell lung cancer. Asian Pac J Cancer Prev. 2019;20(1):45-51. doi: https://doi.org/10.31557/apjcp.2019.20.1.45 DOI: https://doi.org/10.31557/APJCP.2019.20.1.45

Hong S, Youk T, Lee SJ, et al. Bone metastasis and skeletal-related events in patients with solid cancer: a Korean nationwide health insurance database study. PLoS One. 2020;15(7):e0234927. doi: https://doi.org/10.1371/journal.pone.0234927 DOI: https://doi.org/10.1371/journal.pone.0234927

von Moos R, Body JJ, Egerdie B, et al. Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases. Support Care Cancer. 2016;24(3):1327-37. doi: https://doi.org/10.1007/s00520-015-2908-1 DOI: https://doi.org/10.1007/s00520-015-2908-1

Faria EM, Araujo BP, Chelles PA, et al. Prognostic factors and functionality in metastatic spinal cord compression: cohort study. Rev Bras Cancerol. 2022;68(2):e-182160. doi: https://doi.org/10.32635/2176-9745.RBC.2022v68n2.2160 DOI: https://doi.org/10.32635/2176-9745.RBC.2022v68n2.2160

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Published

2024-06-03

How to Cite

1.
Chelles PA, Oliveira LC de, Couto LS, Sampaio SG dos SM, Bergmann A. Factors Associated with Neuropathic Pain in Cancer Patients Admitted to a Palliative Care Unit. Rev. Bras. Cancerol. [Internet]. 2024 Jun. 3 [cited 2024 Jun. 30];70(2):e-114603. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/4603

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