Relato de Dados Clínicos Periodontais em Pacientes com Câncer de Cabeça e Pescoço: Opinião de Especialistas

Authors

  • Rodrigo Dutra Norberto de Oliveira Universidade do Estado do Rio de Janeiro (Uerj), Faculdade de Odontologia, Programa de Pós-graduação em Odontologia. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0002-9653-1978
  • Fernanda Brito Universidade do Estado do Rio de Janeiro (Uerj), aculdade de Odontologia, Departamento de Procedimentos Clínicos Integrados. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0003-4067-9372
  • Ricardo Guimarães Fischer Universidade do Estado do Rio de Janeiro (Uerj), aculdade de Odontologia, Departamento de Procedimentos Clínicos Integrados. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0003-0695-8159
  • Raquel Richelieu Lima de Andrade Universidade do Estado do Rio de Janeiro (Uerj), Hospital Universitário Pedro Ernesto, Centro Universitário de Controle do Câncer. Rio de Janeiro (RJ), Brasil. https://orcid.org/0009-0002-7139-5639
  • Guilherme Goulart Cabral-Oliveira Faculdade de Ciências Médicas, Programa de Pós-graduação em Microbiologia. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0001-9762-4669
  • Fernando Luiz Dias Instituto Nacional de Câncer (INCA), Departamento de Cirurgia de Cabeça e Pescoço. Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0003-1000-7436

DOI:

https://doi.org/10.32635/2176-9745.RBC.2026v72n4.5732

Keywords:

Head and Neck Neoplasms, Periodontal Diseases, Inflammation

Abstract

Over the past two decades, inflammation has been recognized as an additional risk indicator for head and neck cancer (HNC). Periodontal diseases, including gingivitis and periodontitis, may contribute to cancer development; however, few studies have incorporated comprehensive clinical periodontal assessments when investigating their association with HNC. This article emphasizes the importance of monitoring periodontal disease in patients with head and neck cancer and explores possible correlations between these conditions. Given the limited evidence available, further studies using gold-standard periodontal examinations in HNC patients are needed, especially studies performing full periodontal examinations and reporting data using the Full-mouth MB-B-D partial protocol. The parallel presentation of both assessment methods would facilitate methodological comparisons, improve the consistency of periodontal data, and support comparisons across different populations. This approach may strengthen the evidence for periodontal disease as a potential predictive risk factor for the development and progression of head and neck cancer.

Downloads

Download data is not yet available.

References

Johnson DE, Burtness B, Leemans CR, et al. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6(1):1893. doi: https://doi.org/10.3390/cancers12071893 DOI: https://doi.org/10.1038/s41572-020-00224-3

Gopinath D, Menon RK, Veettil SK, et al. Periodontal diseases as putative risk factors for head and neck cancer: systematic review and meta-analysis. Cancers (Basel). 2020;12(7):1-15. doi: https://doi.org/10.3390/cancers12071893 DOI: https://doi.org/10.3390/cancers12071893

Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357(9255):539-45. doi: https://doi.org/10.1016/S0140-6736(00)04046-0 DOI: https://doi.org/10.1016/S0140-6736(00)04046-0

Chapple ILC, Mealey BL, Van Dyke TE, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(Suppl1):68-77. doi: https://doi.org/10.1002/JPER.17-0719 DOI: https://doi.org/10.1002/JPER.17-0719

Sanz M, Herrera D, Kebschull M, et al. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2020;47(Suppl 22):4-60. doi: https://doi.org/10.1111/jcpe.13290 DOI: https://doi.org/10.1111/jcpe.13290

Komlós G, Csurgay K, Horváth F, et al. Periodontitis as a risk for oral cancer: a case–control study. BMC Oral Health. 2021;21(640):1-9. doi: https://doi.org/10.1186/s12903-021-01998-y DOI: https://doi.org/10.1186/s12903-021-01998-y

Gupta B, Kumar N, Johnson NW. Periodontitis, oral hygiene habits, and risk of upper aerodigestive tract cancers: a case-control study in Maharashtra, India. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2020;129(4):339-46. doi: https://doi.org/10.1016/j.oooo.2019.12.001 DOI: https://doi.org/10.1016/j.oooo.2019.12.001

Laprise C, Shahul HP, Madathil SA, et al. Periodontal diseases and risk of oral cancer in Southern India: results from the HeNCe Life study. Int J Cancer. 2016;139(7):1512-9. doi: https://doi.org/10.1002/ijc.30201 DOI: https://doi.org/10.1002/ijc.30201

Moraes RC, Dias FL, Figueredo CMS, et al. Association between chronic periodontitis and oral/oropharyngeal cancer. Braz Dent J. 2016;27(3):261-66. doi: https://doi.org/10.1590/0103-6440201600754 DOI: https://doi.org/10.1590/0103-6440201600754

Rezende CP, Ramos MB, Daguíla CH, et al. Alterações da saúde bucal em portadores de câncer da boca e orofaringe. Rev Bras Otorrinolaringol. 2008;74(4):596-600. doi: https://doi.org/10.1590/S0034-72992008000400018 DOI: https://doi.org/10.1590/S0034-72992008000400018

Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol. 2005;76(3):406-10. doi: https://doi.gov/10.1902/jop.2005.76.3.406 DOI: https://doi.org/10.1902/jop.2005.76.3.406

Gallimidi AB, Fischman S, Revach B, et al. Periodontal pathogens porphyromonas gingivalis and fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6(26):22613-23. doi: https://doi.org/10.18632/oncotarget.4209 DOI: https://doi.org/10.18632/oncotarget.4209

Nieminen MT, Listyarifah D, Hagström J, et al. Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation. BJC. 2017;118(3):428-34. doi: https://doi.org/10.1038/bjc.2017.409 DOI: https://doi.org/10.1038/bjc.2017.409

Zepeda-Rivera M, Minot SS, Bouzek H, et al. A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche. Nature. 2024; 68:424-32. doi: https://doi.org/10.1038/s41586-024-07182-w DOI: https://doi.org/10.1038/s41586-024-07182-w

Belibasakis GN, Belstrøm D, Eick S, et al. Periodontal microbiology and microbial etiology of periodontal diseases: historical concepts and contemporary perspectives. Periodontol 2000. 2023;1-17. doi: https://doi.org/10.1111/prd.12473 DOI: https://doi.org/10.1111/prd.12473

Rapidis AD, Dijkstra PU, Roodenburg JLN, et al. Trismus in patients with head and neck cancer: etiopathogenesis, diagnosis and management. Clin Otolaryngol. 2015;40(6):516-26. doi: https://doi.gov/10.1111/coa.12488 DOI: https://doi.org/10.1111/coa.12488

Benigeri M, Brodeur JM, Payette M, et al. Community periodontal index of treatment needs and prevalence of periodontal conditions. J Clin Periodontol. 2000;27(5):308-12. doi: https://doi.org/10.1034/j.1600-051x.2000.027005308.x DOI: https://doi.org/10.1034/j.1600-051x.2000.027005308.x

Romano F, Perotto S, Castiglione A, et al. Prevalence of periodontitis: misclassification, under-recognition or over-diagnosis using partial and full-mouth periodontal examination protocols. Acta Odontol Scand. 2019;77(3):189-96. doi: https://doi.org/10.1080/00016357.2018.1535136 DOI: https://doi.org/10.1080/00016357.2018.1535136

Alawaji YN, Alshammari A, Aleksejuniene J. Accuracy of estimating periodontitis and its risk association using partial-mouth recordings for surveillance studies: a systematic review and meta-analysis. Int J Dent. 2022;2022:1-16. doi: https://doi.org/10.1155/2022/7961199 DOI: https://doi.org/10.1155/2022/7961199

Tran DT, Gay I, Du XL, et al. Assessing periodontitis in populations: a systematic review of the validity of partial‐mouth examination protocols. J Clin Periodontol. 2013;40(12):1064-71. doi: https://doi.org/10.1111/jcpe.12165 DOI: https://doi.org/10.1111/jcpe.12165

Downloads

Published

2026-08-13

How to Cite

1.
Oliveira RDN de, Brito F, Fischer RG, Andrade RRL de, Cabral-Oliveira GG, Dias FL. Relato de Dados Clínicos Periodontais em Pacientes com Câncer de Cabeça e Pescoço: Opinião de Especialistas. Rev. Bras. Cancerol. [Internet]. 2026 Aug. 13 [cited 2026 Nov. 11];72(4):e-125732. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/5732

Issue

Section

OPINION ARTICLE

Most read articles by the same author(s)