Mitomicina C e Vimblastina no Tratamento do Câncer de Mama Refratário
DOI:
https://doi.org/10.32635/2176-9745.RBC.1988v34n2/3.3155Palabras clave:
Câncer de Mama, Mitomicina C, VimblastinaResumen
Entre agosto/83 e dezembro/85, oitenta e três pacientes portadores de câncer de mama avançado e resistente a múltiplos agentes quimioterápicos foram tratados com Mitomicina C 10mg/m2 iv 6/6 semanas e Vimblastina 6mg/m2 iv 3/3 semanas. Setenta e dois pacientes eram avaliáveis quanto à resposta. Observou-se resposta completa em 3 pacientes (4,1 %), resposta parcial em 7 pacientes (9,7%) e doença estabilizada por 3 ou mais meses em 23 pacientes (31,9%). A toxicidade foi considerada moderada, consistindo principalmente de mielossupressão, neurotoxicidade e náuseas. A combinação Mitomicina C e Vimblastina beneficiou um número significativo de pacientes portadores de câncer de mama refratário, podendo ser considerada especialmente naqueles com um bom "performance status".
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