Rabdomiosarcoma del Subtipo Alveolar en la Región Tenar con Invasión de los Ganglios Linfáticos Axilares en Adulto: Informe de Caso
DOI:
https://doi.org/10.32635/2176-9745.RBC.2025v71n2.4969Palabras clave:
Rabdomiosarcoma, Neoplasias de los Tejidos Blandos, Adulto, Amputación Quirúrgica, Informe de CasoResumen
Introducción: El rabdomiosarcoma es un subtipo de sarcoma maligno de tejidos blandos de alto grado, con células tumorales que se asemejan a los mioblastos esqueléticos. Los dos subtipos principales son el alveolar, que aparece principalmente en las extremidades, y el embrionario, que aparece más comúnmente en la cabeza y el cuello. Reporte del caso: Mujer de 33 años acudió a consulta médica por la presencia de una lesión violácea y no ulcerada en la región tenar de la mano izquierda, con linfadenomegalia en la axila izquierda. Inicialmente, la resonancia magnética reveló una formación expansiva en la región tenar, y una biopsia de esa área mostró una neoplasia poco diferenciada. El examen inmunohistoquímico sugirió rabdomiosarcoma alveolar de alto grado. Se indicó la amputación del primer metacarpiano de la mano izquierda y la disección axilar de los ganglios linfáticos comprometidos. Conclusión: El caso reportado presenta una localización anatómica y un rango de edad poco comunes para el rabdomiosarcoma, y los factores clave para un buen seguimiento clínico son el diagnóstico precoz y la terapia multimodal.
Descargas
Citas
Kumar V, Aster JC, Abbas AK. Robbins Patologia Básica. 10. ed. Rio de Janeiro: Guanabara Koogan; 2021. 1421 p.
Cassidy J, Bissett D, Spence RAJ, et al. Oxford handbook of oncology. 4. ed. Oxford: Oxford University Press; 2015. DOI: https://doi.org/10.1093/med/9780199689842.001.0001
Agarwala S. Pediatric rhabdomyosarcomas and nonrhabdomyosarcoma soft tissue sarcoma. J Indian Assoc Pediatr Surg [Internet]. 2006 [acesso 2024 maio 3];11(1):15. Disponível em: http://www.jiaps.com/text.asp?2006/11/1/15/24632 DOI: https://doi.org/10.4103/0971-9261.24632
Agaram NP. Evolving classification of rhabdomyosarcoma. Histopathology [Internet]. 2022 [acesso 2024 maio 3];80(1):98-108. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425116/ DOI: https://doi.org/10.1111/his.14449
Egas-Bejar D, Huh WW. Rhabdomyosarcoma in adolescent and young adult patients: current perspectives. Adolesc Health Med Ther [Internet]. 2014 [acesso 2024 maio 3];5:115-25. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069040/ DOI: https://doi.org/10.2147/AHMT.S44582
Xarchas K, Papavassiliou N, Tsoutseos N, et al. Rhabdomyosarcoma of the hand. Two case reports and a review of the literature. J Hand Surg Edinb Scotl. 1996;21(3):325-9. DOI: https://doi.org/10.1016/S0266-7681(05)80194-9
Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.
Skapek SX, Ferrari A, Gupta AA, et al. Rhabdomyosarcoma. Nat Rev Dis Primer. 2019;5(1):1. DOI: https://doi.org/10.1038/s41572-018-0051-2
Seyhan N, Keskin M, Tosun Z, et al. Rhabdomyosarcoma in an adult hand. J Plast Surg Hand Surg. 2013;47(5):422-4. DOI: https://doi.org/10.3109/2000656X.2012.731580
Okcu MF. Rhabdomyosarcoma in childhood, adolescence, and adulthood: treatment. Uptodate [Internet]. 2023 [acesso 2024 maio 3];1. Disponível em: https://www.uptodate.com/contents/rhabdomyosarcoma-inchildhood-adolescence-and-adulthood-treatment
Van Erp A, Versleijen-Jonkers Y, Van der Graaf W, et al. Targeted therapy–based combination treatment in rhabdomyosarcoma. Mol Cancer Ther. 2018;17:1365-80. DOI: https://doi.org/10.1158/1535-7163.MCT-17-1131
Taza F, Kanwal A, Zulty M, et al. High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature. J Community Hosp Intern Med Perspect. 2020;10(3):287-9. doi: https://www.doi.org.br/10.1080/20009666.2020.1766820 DOI: https://doi.org/10.1080/20009666.2020.1766820
Gorunova L, Bjerkehagen B, Micci F, et al. Cytogenetic and molecular study of an adult sclerosing rhabdomyosarcoma of the extremity: MYOD1-mutation and clonal evolution. Cancer Genom Proteom. 2020;17(5):563-9. doi: https://www.doi.org/10.21873/cgp.20212
Widikusumo A, Triyanto L, Istutiningrum R, et al. Adult alveolar rhabdomyosarcoma on extremity, successful treatment with radiotherapy following chemotherapy: serial case report. Int J Appl Basic Med Res. 2019;9(2):121-3. doi: https://www.doi.org/10.4103/ijabmr.IJABMR_100_18
Martorell M, Ortiz CM, Garcia JA. Testicular fusocellular rhabdomyosarcoma as a metastasis of elbow sclerosing rhabdomyosarcoma: a clinicopathologic, immunohistochemical and molecular study of one case. Diagn Pathol. 2010;5(52):1-6. doi: https://www.doi.org/10.1186/1746-1596-5-52 DOI: https://doi.org/10.1186/1746-1596-5-52
Othman H, Mohamed Haflah NH, Sani MH, et al. Distal tibiofibular joint reconstruction using autograft in a rare case of lower limb sclerosing/spindle cell rhabdomyosarcoma: a two-year follow-up. Cureus. 2023;15(8):e42869. doi: https://www.doi.org/10.7759/cureus.42869 DOI: https://doi.org/10.7759/cureus.42869
Rasekhi RT, Hosseini N, Babapoor-Farrokhran S, et al. A rare case of primary adult cardiac rhabdomyosarcoma with lower extremity metastasis. Radiol Case Rep. 2023;18(5):1666-70. DOI: https://doi.org/10.1016/j.radcr.2023.01.089
Widikusumo A, Triyanto L, Istutiningrum R, et al. Adult alveolar rhabdomyosarcoma on extremity, successful treatment with radiotherapy following chemotherapy: serial case report. Int J Appl Basic Med Res. 2019;9(2):121-3. DOI: https://doi.org/10.4103/ijabmr.IJABMR_100_18
Bar Y, Merimsky O. Soft-Tissue sarcoma following traumatic injury: case report and review of the literature. Front Oncol. 2017;7:134. doi: https://www.doi.org/10.3389/fonc.2017.00134 DOI: https://doi.org/10.3389/fonc.2017.00134
Fang AS, Morse LJ, Wustrack R, et al. Complete regression of rhabdomyosarcoma in an adult secondary to postoperative wound infection following limb salvage surgery: a case report. Perm J. 2020;25(1):1. doi: https://www.doi.org/10.7812/TPP/20.172 DOI: https://doi.org/10.7812/TPP/20.172
Valone III F, Liu J, Genrich G, et al. Alveolar rhabdomyosarcoma causing acute compartment syndrome of the forearm: a case report and review of the literature. J Hand Microsurg. 2014;6(2):92-5. doi: https://www.doi.org/10.1007/s12593-013-0108-0 DOI: https://doi.org/10.1007/s12593-013-0108-0
Gorunova L, Bjerkehagen B, Micci F, et al. Cytogenetic and molecular study of an adult sclerosing rhabdomyosarcoma of the extremity: MYOD1-mutation and clonal evolution. Cancer Genom Proteom. 2020;17(5):563-9. doi: https://www.doi.org/10.21873/cgp.20212 DOI: https://doi.org/10.21873/cgp.20212
Fabian ID, Hildebrand GD, Wilson S, et al. Alveolar rhabdomyosarcoma of the foot metastasizing to the Iris: report of a rare case. BMC Cancer. 2016;16(447):1-3. doi: https://www.doi.org/10.1186/s12885-016-2496-6 DOI: https://doi.org/10.1186/s12885-016-2496-6
Fisher MH, Woods JFC, Bartlett EK, et al. A rare case of rhabdomyosarcoma identified in a VRAM flap after lower extremity reconstruction. J Surg Case Rep. 2023;2023(3):rjad083. doi: https://www.doi.org/10.1093/jscr/rjad083 DOI: https://doi.org/10.1093/jscr/rjad083
Publicado
Cómo citar
Número
Sección
Licencia
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
