Tratamento Quimioterápico Adjuvante no Câncer Operável da Mama
DOI:
https://doi.org/10.32635/2176-9745.RBC.1987v33n2.3202Palavras-chave:
Câncer da Mama, Quimioterapia AdjuvanteResumo
Em 1981 foi padronizada no Hospital de Oncologia - INAMPS/RIO (H.O.), a conduta terapêutica para o câncer operável da mama. Apresentamos os resultados preliminares obtidos com o tratamento proposto, que consistiu da cirurgia isolada ou associada à quimioterapia adjuvante (Qt adj), em 333 pacientes. A conduta cirúrgica consistiu de mastectomia clássica à Halsted (H) ou modificada tipo Patey (P) e quadrantectomia com esvaziamento axilar (SE). A radioterapia adjuvante ou pós-mastectomia não foi utilizada no presente estudo. A Qt adj consistiu de administração cíclica de ciclo fosfamida, methotrexate e fluorouracil\CMF) endovenosos, repetidos a cada 21/21 dias, por oito ciclos (CMF). Avaliamos e comparamos o intervalo livre de doença (ILD) e a sobrevida (SV) de 139 pacientes que tinham axila histologicamente comprometida (N+), com 53 pacientes do grupo controle (N+ Cl e 141 pacientes cuja axila não apresentava comprometimento metastático ao exame histológico (N—). Examinamos também a incidência de recidivas e metástases bem como a toxicidade decorrente do tratamento com um período médio de follow-up em torno de 20 meses.
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