Cleft Lip/Palate and Cancer: a True Connection

  • Alexandre Rezende Vieira University of Pittsburgh, School of Dental Medicine, Department of Oral & Craniofacial Sciences. Pittsburgh, PA, USA.
Palavras-chave: Cleft Lip, Cleft Palate, Neoplasms

Resumo

Multifactorial cleft lip and palate is relatively common in populations (1 in every 700 livebirths). Individuals born with clefts require lifelong treatment after initial surgical repair and data suggested that their lifespan is shorter, possibly due to cancer or psychiatric conditions. Molecular defects that alter facial development in utero appear to later in life predispose to cancer. Common polymorphisms in e-cadherin and an endoplasmic reticulum transmembrane sensor gene appear to hold the promise to be biomarkers that may help to define individual risks to cancer, in the presence or not of family history of clefts.

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Publicado
2021-09-29
Como Citar
1.
Vieira AR. Cleft Lip/Palate and Cancer: a True Connection. Rev. Bras. Cancerol. [Internet]. 29º de setembro de 2021 [citado 7º de dezembro de 2021];67(4):e-062396. Disponível em: https://rbc.inca.gov.br/revista/index.php/revista/article/view/2396
Seção
ARTIGOS DE OPINIÃO