Review article: chromosomal diagnosis in rhabdomyosarcoma

Authors

  • Plínio Cerqueira dos Santos Cardoso Departamento de Genética, Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP.
  • Marcelo de Oliveira Bahia Departamento de Genética, Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP. Ciências Biológicas, Universidade Federal do Pará, Belém, PA.
  • Marcelo Razera Baruffi Departamento de Pediatria (FMRP-USP), Ribeirão Preto, SP.
  • Juliana Simão Nina de Azevedo Ciências Biológicas, Universidade Federal do Pará, Belém, PA.
  • André Salim Khayat Ciências Biológicas, Universidade Federal do Pará, Belém, PA.
  • Marilia de Arruda Cardoso Smith Disciplina de Genética, Departamento de Morfologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP.
  • Paulo Pimentel de Assumpção Serviço de Cirurgia, Hospital Universitário João de Barros Barreto (UFPA), Belém, PA.
  • Rommel Rodríguez Burbano Ciências Biológicas, Universidade Federal do Pará, Belém, PA. Disciplina de Genética, Departamento de Morfologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP.
  • Luiz Gonzaga Tone Departamento de Pediatria (FMRP-USP), Ribeirão Preto, SP.

DOI:

https://doi.org/10.32635/2176-9745.RBC.2005v51n1.1998

Keywords:

Chromosomes, Cytogenetics, Rhabdomyosarcomas

Abstract

Rhabdomyosarcomas (RMS) are considered clinically aggressive tumors, originated from immature mesenchymal cells and characterized by the presence of cells with an ill-defined differentiation. The use of conventional cytogenetic techniques has contributed considerably to distinguish the alveolar RMSs from the other types of solid tumors in children and adolescents. Besides that, it provides important prognostic informations about alveolar RMSs. Thus, the present work was aimed at reviewing the cytogenetic alterations observed in the different histological subtypes of RMS, focusing not only on the studies performed with conventional cytogenetics, but also on new approaches used in the study of neoplasms, such as FISH, CGH, SKY and M-FISH. These methodologies have contributed significantly to a better understanding of the karyotype heterogeneity observed in RMS.

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Published

2005-03-31

How to Cite

1.
Cardoso PC dos S, Bahia M de O, Baruffi MR, Azevedo JSN de, Khayat AS, Smith M de AC, Assumpção PP de, Burbano RR, Tone LG. Review article: chromosomal diagnosis in rhabdomyosarcoma. Rev. Bras. Cancerol. [Internet]. 2005 Mar. 31 [cited 2024 Jul. 22];51(1):59-65. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/1998

Issue

Vol. 51 No. 1 (2005): Jan./Feb./Mar.

Section

LITERATURE REVIEW

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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