Efeito da dietílnitrosamína, associada ou não a fenobarbital e diazepam, sobre fígado de gerbil (Meriones unguiculatus)
DOI:
https://doi.org/10.32635/2176-9745.RBC.1992v38n1.3068Keywords:
Diethylnitrosamine, Fenobarbital, Diazepam, Gerbil, Hepatotoxicity, HepatocarcinogenesisAbstract
Chemically induced hepatic changes were studied in gerbils submitted to a chronic subcutaneous treatment of diethylnitrosamine in association or not with oral fenobarbital administration and diazepam intraperitoneally inJected. The treatments were carried out for twenty-five weeks and morphological studies were performed between the 25th and the 50th week. Diethylnitrosamine was a potente hepatotoxic agent causing cytomegalia, multifocal necrosis, ductular proliferation and fibrosis. Such effects were markedly reduced following simultaneous administration of phenobarbital. Moreover, hepatocarcinomas were observed (mainly with a trabecular pattern) on the 36th week. Concomitant treatment of diazepam did not alter the hepatotoxicity but could diminish the hepatocarcinogenic effect of diethylnitrosamine because only preneoplastic lesions were registered at the 50th week.
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