Tratamento de Linfomas Não-Hodgkin Agressivos com CHOP-BLEO: Estudo retrospectivo
DOI:
https://doi.org/10.32635/2176-9745.RBC.1987v33n2.3198Keywords:
Non-Hodgkin Lymphomas, ChemotherapyAbstract
Agressive" non-Hodgkin lymphomas (146 cases) were studied in their response to Chop-Bleo therapy. There were 56.2% of complete remission in the 146 cases. Lmportant factors in prognosis included histologic data, presence of symptoms and clinical staging of the disease. Abdominal tumors (larger than 10cm in diameter) and presence of symptoms were influent on relapses. Five-year survival was 35% and four factors were influent in this aspect: age, previous treatments, presence of abdominal tumor, and, the most influent of all, complete remission. Toxicity was low, with only one death. Results are similar to those obtained by other medical centers.
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References
Grogan Ml, Jones SE - Atlas of the mmunologic, pathologic and clinical aspects of the malignant lymphomas. Tucson, University of Arizona Coliege of Medicine, 1984.
Rosemberg SA - Non-Hodkins iymphomas. in: Calabresi P. et al, medical oncology basic principies and clinicai management of cancer. New York, Macmiilan, 1985; 476-93.
Fisher RI, et aI. - Factors predicting iong-term survivai in diffuse mixed, histiocitic or undifferentiated iymphoma. Blood, 1981; 58:45-51. DOI: https://doi.org/10.1182/blood.V58.1.45.bloodjournal58145
Jagannath S, et al. - Stage iv diffuse iarge-cell lymphoma: a Iong-term analysis. Journal of Clinical Oncology, 1985; 3: 39-47. DOI: https://doi.org/10.1200/JCO.1985.3.1.39
Rodriguez V, et al. - Combination chemotherapy ("Chop-Bieo") in advanced (Non-Hodgkin) mahgnant iymp oma. Biood, 1977; 49:325-33. DOI: https://doi.org/10.1182/blood.V49.3.325.bloodjournal493325
Cochran WG - Statistical methods for strenghtening the common qui-quadrado tests. Biometrics, 10:417-51. DOI: https://doi.org/10.2307/3001616
Anderson 5, et al. - Statistical methods for comparativeStudies. New York, Wiley, 1980.
de Vita Jr V, Heliman 5 - Hodgkins disease and the non-Hodgkins Iymphoma. in: de Vita Jr VT e al. Cancer; principies |and|practice|of oncology. Philadelphia, J.B. Lippincott, 1982; 1926.
Jones ES, et al. - Chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone alone or with ievamrsoie plus BCG for mahgnant Iymphoma: a Southwest Oncology Group Study. Journal of Clinical Oncology, 1985; 3: 1318-24. DOI: https://doi.org/10.1200/JCO.1985.3.10.1318
Lee R, et al. - A 10-year update of Chop-Bleo in the treatment of diffuse large-cell lymphoma. Journal of Clinical Oncology, 1986; 4: 1455-61. DOI: https://doi.org/10.1200/JCO.1986.4.10.1455
Herrmann R, et al. - The influence of histoiogic type on the Iymphomas. Cancer, 1982; 49: 314-22. DOI: https://doi.org/10.1002/1097-0142(19820115)49:2<314::AID-CNCR2820490218>3.0.CO;2-C
Fisher RI, et al - Diffuse agressive iymphomas increased survival after alternating flexible sequences of PROMACE and MOPP chemotherapy. Ann. int. Med., 1983, 98: 304-9. DOI: https://doi.org/10.7326/0003-4819-98-3-304
Lorico DL, de Vita Jr VT - Lymphomas. in: Pinedo HM, Charbner DA. Cancer chemotherapy 1983. Amsterdam, Eisevier, 1983; 248-81.
Gaynor ER, et al. - Treatment of diffuse histiocitic Iymphoma (DHL) With COMLA (Cyclophosphamide, Oncovin, Methotrexate, Leucovorin, Cytosine Arabinoside) a 10-Year experience in a single instituition. J. Chn Oncol., 1985; 3; 1596-604. DOI: https://doi.org/10.1200/JCO.1985.3.12.1596
Newcomer LN, et al. - Randomized study comparing doxorubicin, cyclophosphamide, vincristine, methotrexate with Ieucovor in rescue and cytarabine (ACOMLA) with cyclophosphamide, doxorubicin, vincristine, prednisone, and bieomycin (CHOP-B) in the treatment of diffuse histiocytic lymphoma. Cancer Treat. Rep., 1982; 66: 1279-84.
Klimo P, Connors JM - Macop-B chemotherapy for the treatment of diffuse large-cell Iymphoma. Ann. int. Med., 1985; 102 596-602. DOI: https://doi.org/10.7326/0003-4819-102-5-596
Coiffier B, et al. - Intensive and sequential com bination chemotherapy for aggressive malignant Iymphomas (Protocol LNH-80). J. Chn. Oncol., 1986; 4: 147-53. DOI: https://doi.org/10.1200/JCO.1986.4.2.147