Quimioterapia da Doença Trofoblástica Complicada Estudo retrospectivo de 79 casos
DOI:
https://doi.org/10.32635/2176-9745.RBC.1987v33n2.3199Keywords:
Complicated Trophoblastic Disease, ChemotherapyAbstract
In a study of complicated throphoblastic disease, 78 patients were evaluated. According to the existence of metastases and other factors influencing (bad) prognosis, four groups of patients were considered. Complete long remission was 93% in no-metastases patients of good or bad prognosis. In patients with metastases, remission was 100% present in good prognosis patients, and 48% in patients with metastases. Hysterectomy was necessary in only five cases. Toxicity related to chemotherapy was low as concerned to Methotrexate (whetherassociated or to folinic acid). It was otherwise light in patients who received polychemotherapy. The author considers it necessary to plan a betterstaging in clinical evaluation of this condition, as well as to obtain better therapy shemes for metastases plus bad prognosis patients.
Downloads
References
Belfort P et al. -- Neoplasia trotoblêstica gestac'ionsi n3u rnetost.ds a A popósito da experiência de 124 casos si.ibrrietidos à quimioterapia. H iM K. Caricci, 1985, 2: 29-45
Goldstein DA, Berkowitz RS -. Management of gestational trophoblaslic neoplasms. in Goldstein DA, Leventhal JM, ed Currenl problems in obstetrics and Gynecology, Chicago, Year Book Medical, 1980, 1 42.
Hansor MB - Trophobiaslic disease. In Van Nageli 38, Barber HAK. Modero concepts of Gynecologic oncology. London John Wright, 1982, 327-60
VVoed Jil et al. - Choriocarcinorna melaslatic to lhe brairi, therapy and prognosis. Serrr Oncol, 1982; 9: 208-12
Disaia PJ, Creasman WI - Clinical Gynecoiogic Oncology. Si Locis, CV. Mosby, 1984; 680.
Newlands ES Trealment of trophoblastic disease. Progr Obst Gynecol, 1984, 3: 15872.
Bagsliawe KD.- Aisk and prognoslic faclors irr lrophoblaslic rreoblaslic neoplasia Cancer, 1976; 38 1373-85. DOI: https://doi.org/10.1002/1097-0142(197609)38:3<1373::AID-CNCR2820380342>3.0.CO;2-E
Mitchell MS et al - Effectiveness cf highdose infusion of Melhotresale followed by leucovorin in carcsroma of lhe head and neck Cancer Eles, 1964, 18 1088-94.
Stone M, Bsghawe KD - in analysis of lhe influences of maternal age, gestational age, contraceptive method and the mode of primary treatment of patients wilh hydaxdiform moles on the incidence of subsequent chemotherapy. Br 3 Ohsr Gynaecol, 1979, 86 782-92 DOI: https://doi.org/10.1111/j.1471-0528.1979.tb10694.x
Lurain AJ et al. - Gestational tropboblastic disease: treatmert results at Brewer Troplroblastic Disease Center. Obsl Gynecol, 1982, 60 354-60
Clayton LA et al - the role of surgery in lhe management of gestational trophoblaslic disease. Sem Oncol, 1982; 9 213-20.
Jones WB .. Gestational trophoblastic neoplasms; lhe role of chemotherapy and surgery. Surg Chn Norlh Am, 1978, 58 167-79 DOI: https://doi.org/10.1016/S0039-6109(16)41443-X
Paslorfide GB, Goldstein DP -- Pregnancv alter hydatidiform mole. Obsl Gynecol, 1973,42 67-70
Athanassion A et al - Central riervous system melaslases of choriocarcirioma; 23 years experience at Charing Cross Hospital Cancer, 1983, 52 1728-35 DOI: https://doi.org/10.1002/1097-0142(19831101)52:9<1728::AID-CNCR2820520929>3.0.CO;2-U
Hammond CB et al. - Trealment ot melaslatic trophoblastic disease good and poor prognosis. Am .3 Obst et Gynecol, 1973, 115 451-7. DOI: https://doi.org/10.1016/0002-9378(73)90389-X
