Quimioterapia com Cisplatinum, Vinblastina e Bleomicina (PVB) em Pacientes Portadores de Tumores Germinativos Avançados do Testiculo
DOI:
https://doi.org/10.32635/2176-9745.RBC.1986v32n2.3238Keywords:
Testicular Tumor, ChemotherapyAbstract
Twenty eight available patients with advanced germ cell testis cancer were treated by combination chemotherapy (CT) with Cisplatinun, Vinblastine and Bleomycin (PVB) and followed by a median period of 35.5 months (range 5-76). Complete remission (CR) with CT alone was achieved in 12/28 (431%) patients, CR with CT associated to radical surgery in 4/28 (14%) patients, with a total of 16/28 (57%) patients becoming disease-free. CR was achieved in 6/7 (86%) patients with minimal advanced disease and alI of them are long term disease free survivors. CR was achieved in 10/21 (47,6%) patients with bulky advanced disease and five (24%) of them are still in their first remission. PVB was an effective and well tolerated treatment for patients with minimal advanced disease but were of less eficacy (only 24% Jong term disease free survivors) in those with bulky disease. Survival curve as described by Kaplan-Meier method, showed a media, survival of 36.6 months and a four-year disease free survival of 48010 patients. Discussion about new chemotherapeutic treatments are presented.
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References
Williams SD, Einhorn LH. Neoplasms of the testis. in: Calabresi P, Schein P, Rosenberg SA, eds Medical oncology: basic principies and clinical management of cancer. New York; Macmillan 1985; 1077-1088.
Einhorn LH, Williams SD. The management of disseminated testicular cancer. In: Einhorn LH, ed Testicular tumors management and treatment. New York; 1980: 117-149.
Einhorn LH, Donohue JP. Peckham MJ, Williams SD, Loehrer PJ. Cancer of the testis. in: De Vita VT, Heilman S, Rosenberg SA, eds Cancer: Principies and pratice of oncology. Philadelphia, JB Lippincott 1985: 979-1011.
Einhorn LH, Donohue JP. Cis-diamminedichioroplatinum, Vinblastine, and Bleomycin combination chemotherapy in disseminated testicular cancer. Ann inter Med 1977; 87: 293-298. DOI: https://doi.org/10.7326/0003-4819-87-3-293
S. Hainsworth JD, Greco FA. Testicular germ cell neoplasms. Amer J Med, 1983; 75: 817-832. DOI: https://doi.org/10.1016/0002-9343(83)90413-8
Stoter G, Vendrik CPJ, Struyvenberg A, et al. Five years survival of patients with disseminated nonseminornatous testicular cancer treated with cisplatinun, vinbIastine and bleomycin. Cancer 1984; 54: 1521-1524. DOI: https://doi.org/10.1002/1097-0142(19841015)54:8<1521::AID-CNCR2820540808>3.0.CO;2-8
Wettfiaufer JN, Feiner AS, Robison WA. Vincristine, cisplatin and bleomycin with surgery in the management of advanced metastatic monseminomatous testis tumors. Cancer. 1984; 53: 203-209. DOI: https://doi.org/10.1002/1097-0142(19840115)53:2<203::AID-CNCR2820530203>3.0.CO;2-U
Einhorn LH, Williams SD. Chemotherapy of disseminated testicular cancer: a random prospective study. Cancer 1980; 46: 1339-1344. DOI: https://doi.org/10.1002/1097-0142(19800915)46:6<1339::AID-CNCR2820460607>3.0.CO;2-J
Huben RP, Williams PD, Pontes JE, Panahon AM, Murphy GP. Seminoma at Roswell Park, 1970 to 1979; an analysis for treatment failures. Cancer 1984; 53:1451-1455. DOI: https://doi.org/10.1002/1097-0142(19840401)53:7<1451::AID-CNCR2820530704>3.0.CO;2-U
Ozois AF, Deisseroth AB, Javadpour N, Bariock A, Messerschimidt GL, Vong RC. Treatment of poor prognostic non-seminomatous testicular cancer with a "high-dose" platinum combination chemotherapy regíment. Cancer 1983; 51: 1803-1807. DOI: https://doi.org/10.1002/1097-0142(19830515)51:10<1803::AID-CNCR2820511008>3.0.CO;2-F
