Quimioterapia Adjuvante com CMF Modificado no Câncer Operável da Mama: Resultados de 4 anos de seguimento
DOI:
https://doi.org/10.32635/2176-9745.RBC.1986v32n4.3280Keywords:
Breast Cancer, Chemotherepy, SurvivalAbstract
Eigthy-six patients with breast cancer and positive axilar limphonodes were subrnitted to a modified radical mastectomy and adjuvant treatment with cyclophosphamyde 600mg/m2, 5-fluouracil 600mg/m2 and methotrexate 40mg/m2 by intravenous route, repetead each 21 days, during six months (eight cycles) (CMF-mod). The CMFmod was started irnmediately after surgery. The results were compared with 186 patients from the same institution (historical controls) treated by Halsted mastectorny and irradiation. At 48 months folllow-up, 72 patients (85%) in the CMFmod treated group were alive with 42 (49%) free of disease. In the control group, 132 (71%) were alive with 94 (51%) free of disease (p=0.70 andp <0.25, NS). There was a trend favoring the CMF treated premenopause woman with 1 to 3 N+: overall survival (SV): 26/26 (100%) and relapse free survival (RFS): 21/26 (81%) when cornpared to controls: SV: 36/44 (83%) and RFS: 30/44 (68%) (p <0. 15 and p <a 80, NS). We conclude that it may be necessary a longer follow-up to confirm the results obtained by Bonadonna.
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