Avaliação do Potencial Cardiotóxico do Vp-16 Através de um Modelo Experimental Utilizando Ratas Albinas: Discussão de Achados Anátomo-Patológicos

Authors

  • Gilberto Schvvartsmann Setor de Oncologia do Hospital de Clínicas de Porto Alegre. Porto Alegre (RS), Brasil.
  • Carmem Lúcia Oliveira da Silva Bolsista do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) -MEC, Brasil.
  • Lucas P. Teixeira Departamento de Fisiologia da Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre (RS), Brasil.
  • Luiza Rangel Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre (RS), Brasil.
  • Richard R. Gurski Fundação Faculdade de Ciências Médicas de Porto Alegre. Porto Alegre (RS), Brasil.
  • Fábio Segal Fundação Faculdade de Ciências Médicas de Porto Alegre. Porto Alegre (RS), Brasil.
  • Ligia B. Coutinho Departamento de Patologia. Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre (RS), Brasil.
  • Maria Marques Departamento de Fisiologia. Instituto de Biociências. Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre (RS), Brasil.

DOI:

https://doi.org/10.32635/2176-9745.RBC.1985v31n2.3323

Keywords:

Vp-16, Cardiotoxicity

Abstract

Based on anedoctal reports from the literature suggesting cardiotoxicity due to VP-16, the authors studied the effects on an eight-weekiy intraperitoneal (IP) injection of VP-16 in a group of fifty Albine rats, compared to Controls receiving isotonic saline during the same period of time. Group A (VP-16) received 5mg/kg weight IP weekly for eight courses. Group B (isotonic saline) had the same volume in isotônic saUne IP. Animais from Group A were killed at two-weekly intervals, according to sub-groups G1, G2, G3, G4 and G5 (10 rats in each interval). Animals from Group B were sacrified at the end of experiment. Anatomopathological studies of myocardium from Group A failed to show significant differences between subgroups, in spite of increasing total dosis. When both groups were compared, there were no statystical differences between the animals from Group A and B (P less 0.05). The authors conclude that there is no significant cardiac damage during the VP-16 therapy, at least in experimental conditions. The case reports found in the literature suggesting the possibility of cardiac damage due to VP-16 are probably secondary to unrelated factors.

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Published

2023-08-08

How to Cite

1.
Schvvartsmann G, Silva CLO da, Teixeira LP, Rangel L, Gurski RR, Segal F, Coutinho LB, Marques M. Avaliação do Potencial Cardiotóxico do Vp-16 Através de um Modelo Experimental Utilizando Ratas Albinas: Discussão de Achados Anátomo-Patológicos. Rev. Bras. Cancerol. [Internet]. 2023 Aug. 8 [cited 2024 Jul. 1];31(2):137-42. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/3323

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ORIGINAL ARTICLE