Oral Manifestations of Leukemia at the Time of Diagnosis

Abstract

Introduction: Leukemia is a pathology that consistent with modifications derived from hematopoietic stem cells, which can generate signs and symptoms in the patient's body. Objective: To verify the oral manifestations of leukemia at the time of diagnosis. Method: A review of the integrative literature was carried out in May and June of 2018 from the PubMed and BIREME databases, using the words registered in the MESH and the DeCS (Health Descriptors), respectively, in English leukemia AND diagnosis AND oral manifestations. We included studies evaluating oral alterations in leukemic patients at the time of diagnosis, published in the bases cited in Portuguese and English, with any study design, except revision of narrative literature and articles published between 1950 to 2018. We excluded articles that did not address the subject of the study, which included individuals other than leukemic patients, with absence of oral manifestations in leukemic patients and articles not found in its full version. Results: Through the search, 353 articles were found, of which 318 were excluded. Thus, 35 articles remained. Conclusion: According to 
the articles found, the surgeon-dentist has great importance at the time of diagnosis of leukemia, since the  first manifestations of this disease occur in the oral cavity, such as gingival bleeding, hyperplasia, gingival swelling, oral ulceration and petechiae.