Qualidade de Vida de Sobreviventes de Câncer Onco-hematológicos Submetidos ao Transplante de Células-Tronco Hematopoiéticas: Revisão Integrativa da Literatura
DOI:
https://doi.org/10.32635/2176-9745.RBC.2022v68n4.2708Palavras-chave:
qualidade de vida, transplante de células-tronco hematopoéticas, hematologia, sobreviventes de câncer, neoplasiasResumo
Introdução: Os avanços no tratamento relacionado ao câncer onco-hematológico têm resultado em um crescente número de pacientes submetidos ao transplante de células tronco-hematopoiéticas (TCTH) com êxito terapêutico, o que exige maior atenção com a qualidade de vida (QV) dos sobreviventes. Objetivo: Identificar a QV dos sobreviventes onco-hematológicos submetidos ao TCTH. Método: Revisão integrativa, entre 2011 a 2021, com busca nas bases de dados LILACS, MEDLINE, IBECS, SciELO e Biblioteca Cochrane. Utilizou-se a estratégia SPIDER para responder às questões norteadoras; e o nível de evidência foi classificado segundo o Instituto Joanna Briggs. Resultados: Vinte e seis artigos foram incluídos. Os instrumentos mais utilizados para medir a QV foram o Quality of Life Questionnare – Core 30 e o Functional Assessment Cancer Therapy-Bone Marrow Transplantation. Variáveis biopsicossociais, educacionais e clínicas, como comorbidades, antecedentes, condições epidemiológicas e tipo de condicionamento não influenciaram significativamente a QV dos sobreviventes onco-hematológico submetidos ao TCTH. A QV apresentou comprometimento na vigência de problemas físicos crônicos, reinternações, encargos financeiros, doença do enxerto contra o hospedeiro, fadiga, sintomas psicológicos, infecções recorrentes, disfunções no funcionamento sexual e fértil, neoplasias secundárias e sintomas físicos como dor e distúrbios do sono. Conclusão: O sobrevivente do TCTH mantém demandas de cuidados biopsicossociais que influenciam negativamente a QV, evidenciando a necessidade de cuidado multidimensional.
Downloads
Referências
González-Ramírez MP, Miravete-Lagunes K, Gómez-de-León A, et al. Health-related quality of life in leukemia survivors of allogeneic hematopoietic stem cell transplantation employing the Mexican reduced-intensity conditioning. Rev Invest Clin [Internet]. 2015 [cited 2019 Sept 30];67(2):109-16. Available from: https://clinicalandtranslationalinvestigation.com/files/ric_2015_67_2_109-116.pdf
Registro Brasileiro de Transplantes: dados númericos da doação de órgãos e transplantes realizados por estado e instituição no período: janeiro/março – 2019 [Internet]. São Paulo: Associação Brasileira de Transplantes de Órgãos. Ano XXV, No 1, 2019 - [acesso 2019 set 30]. Disponível em: http://www.abto.org.br/abtov03/Upload/file/RBT/2019/RBT-2019-1%20trim%20-%20Pop.pdf
Brice L, Gilroy N, Dyer G, et al. Haematopoietic stem cell transplantation survivorship and quality of life: is it a small world after all? Support Care Cancer. 2017;25(2):421-7. doi: https://doi.org/10.1007/s00520-016-3418-5
Matias AB, Oliveira-Cardoso EA, Mastropietro AP, et al. Qualidade de vida e transplante de células-tronco hematopoéticas alogênico: um estudo longitudinal. Estud Psicol (Campinas). 2011;28(2):187-97. doi: https://doi.org/10.1590/S0103-166X2011000200006
Marzorati C, Riva S, Pravettoni G. Who is a cancer survivor? A systematic review of published definitions. J Cancer Educ. 2017;32(2):228-37. doi: https://doi.org/10.1007/s13187-016-0997-2
Cooke A, Smith D, Booth A. Beyond PICO: the SPIDER tool for qualitative evidence synthesis. Qual Health Res. 2012;22(10):143543. doi: https://doi.org/10.1177/1049732312452938
Joanna Briggs Institute. JBI levels of evidence [Internet]. Adelaide (AU): University of Adelaide; 2020 June [cited 2020 Nov 11] Available from: https://jbi.global/sites/default/files/2020-07/Supporting_Doc_JBI_Levels_of_Evidence.pdf
Mo XD, Xu LP, Liu DH, et al. Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT. Bone Marrow Transplant. 2012;47(9):1201-5. doi: https://doi.org/10.1038/bmt.2011.250
Hamilton JG, Wu LM, Austin JE, et al. Economic survivorship stress is associated with poor health-related quality of life among distressed survivors of hematopoietic stem cell transplantation. Psychooncology. 2013;22(4):911-21. doi: https://doi.org/10.1002/pon.3091
Janicsák H, Masszi T, Reményi P, et al. Quality of life and its socio-demographic and psychological determinants after bone marrow transplantation. Eur J Haematol. 2013;91(2):135-40. doi: https://doi.org/10.1111/ejh.12126
Gifford G, Sim J, Horne A, et al. Health status, late effects and long-term survivorship of allogeneic bone marrow transplantation: a retrospective study. Intern Med J. 2014;44(2):139-47. doi: https://doi.org/10.1111/imj.12336
Bevans MF, Mitchell SA, Barrett JA, et al. Symptom distress predicts long-term health and well-being in allogeneic stem cell transplantation survivors. Biol Blood Marrow Transplant. 2014;20(3):387-95. doi: https://doi.org/10.1016/j.bbmt.2013.12.001
Kurosawa S, Yamaguchi T, Mori T, et al. Patient-reported quality of life after allogeneic hematopoietic cell transplantation or chemotherapy for acute leukemia. Bone Marrow Transplant. 2015;50(9):1241-9. doi: https://doi.org/10.1038/bmt.2015.137
Kenzik K, Huang IC, Rizzo JD, et al. Relationships among symptoms, psychosocial factors, and health-related quality of life in hematopoietic stem cell transplant survivors. Support Care Cancer. 2015;23(3):797-807. doi: https://doi.org/10.1007/s00520-014-2420-z
Rosenberg AR, Syrjala KL, Martin PJ, et al. Resilience, health, and quality of life among long-term survivors of hematopoietic cell transplantation. Cancer. 2015;121(23):4250-7. doi: https://doi.org/10.1002/cncr.29651
Rocha V, Proença SFFS, Marques ACB, et al. Social impairment of patients undergoing hematopoietic stem cell transplant. Rev Bras Enf. 2016;69(3):454-60. doi: https://doi.org/10.1590/0034-7167.2016690310i
Proença SFFS, Machado CM, Coelho RCFP, et al. Quality of life of patients with graft-versus-host disease (GvHD) post-hematopoietic stem cell transplantation. Rev Esc Enfer USP. 2016;50(6):953-8. doi: https://doi.org/10.1590/S0080-623420160000700011
Gifford G, Gilroy N, Dyer G, et al. The experience of survival following allogeneic haematopoietic stem cell transplantation in New South Wales, Australia. Bone Marrow Transplant. 2016;51(10):1361-8. doi: https://doi.org/10.1038/bmt.2016.135
Clavert A, Peric Z, Brissot E, et al. Late complications and quality of life after reduced-intensity conditioning allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2017;23(1):140-6. doi: https://doi.org/10.1016/j.bbmt.2016.10.011
Marques ACB, Proença SFFS, Machado CAM, et al. Quality of life in the first six months post-hematopoietic stem cell transplantation. Texto Contexto Enferm. 2017;26(3):e5040016. doi: https://doi.org/10.1590/0104-07072017005040016
King SD, Fitchett G, Murphy PE, et al. Spiritual or religious struggle in hematopoietic cell transplant survivors. Psychooncology. 2017;26(2):270-7. doi: https://doi.org/10.1002/pon.4029
El-Jawahri A, Fishman SR, Vanderklish J, et al. Pilot study of a multimodal intervention to enhance sexual function in survivors of hematopoietic stem cell transplantation. Cancer. 2018;124(11):2438-46. doi: https://doi.org/10.1002/cncr.31333
King SDW, Fitchett G, Murphy PE, et al. Religious/spiritual struggle in young adult hematopoietic cell transplant survivors. J Adolensc Young Adult Oncol. 2018;7(2):210-6. doi: https://doi.org/10.1089/jayao.2017.0069
Devins GM, Mah K, Messner HA, et al. Quality of life trajectories during the first year following hematopoietic cell transplantation: an inception cohort study. Support Care Cancer. 2018;26(7):2379-86. doi: https://doi.org/10.1007/s00520-018-4059-7
Shaw BE, Syrjala KL, Onstad LE, et al. PROMIS Measures can be used to assess symptoms and function in long-term hematopoietic cell transplantation survivors. Cancer. 2018; 124(4):841-9. doi: https://doi.org/10.1002/cncr.31089
Solh MM, Bashey A, Solomon SR, et al. Long term survival among patients who are disease free at 1-year post allogeneic hematopoietic cell transplantation: a single center analysis of 389 consecutive patients. Bone Marrow Transplant. 2018;53(5):576-83. doi: https://doi.org/10.1038/s41409-017-0076-2
Park J, Wehrlen L, Mitchell SA, et al. Fatigue predicts impaired social adjustment in survivors of allogeneic hematopoietic cell transplantation (HCT). Support Care Cancer. 2019;27(4):1355-63. doi: https://doi.org/10.1007/s00520-018-4411-y
Lemieux C, Ahmad I, Bambace NM, et al. Evaluation of the impact of autologous hematopoietic stem cell transplantation on the quality of life of older patients with lymphoma. Biol Blood Marrow Transplant. 2020;26(1):157-61. doi: https://doi.org/10.1016/j.bbmt.2019.09.007
Brice L, McErlean G, Donovan C, et al. Fear of cancer recurrence following allogeneic haematopoietic stem cell transplantation (HSCT) for haematological malignancy: a cross-sectional study. Eur J Oncol Nurs. 2020;49:101845. doi: https://doi.org/10.1016/j.ejon.2020.101845
Georges GE, Bar M, Onstad L, et al. Survivorship after autologous hematopoietic cell transplantation for lymphoma and multiple myeloma: late effects and quality of life. Biol Blood Marrow Transplant. 2020;26(2):407-12. doi: https://doi.org/10.1016/j.bbmt.2019.10.002
Harrison RA, Sharafeldin N, Rexer JL, et al. Neurocognitive impairment after hematopoietic stem cell transplant for hematologic malignancies: phenotype and mechanisms. Oncologist. 2021;26(11):e2021-e2033. doi: https://doi.org/10.1002/onco.13867
Azevedo W. Doença enxerto versus hospedeiro aguda A- GVHD. Rev Bras Hematol Hemoter. 2010;32(Suppl 1):16-21. doi: https://doi.org/10.1590/S1516-84842010005000060
McGowan JV, Chung R, Maulik A, et al. Anthracycline chemotherapy and cardiotoxicity. Cardiovasc Drugs Ther. 2017;31(1):63-75. doi: https://doi.org/10.1007/s10557-016-6711-0
Borges JA, Quintão MMP, Chermont SSMC, et al. Fatigue: a complex symptom and its impact on cancer and heart failure. Int J Cardiovasc Sci. 2018;31(4):433- 42. doi: https://doi.org/10.5935/2359-4802.20180027
Póvoa VCA. Mortalidade relacionada ao transplante e fatores associados em pacientes submetidos ao transplante de células-tronco hematopoiéticas: estudo de coorte [dissertação]. São Paulo: Universidade de São Paulo; 2015.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
