Perfil Clínico-Epidemiológico e Qualidade de Vida Relacionada à Saúde de Mulheres com Câncer de Mama durante Tratamento Quimioterápico: Estudo Observacional

Autores

DOI:

https://doi.org/10.32635/2176-9745.RBC.2022v68n4.3164

Palavras-chave:

neoplasias da mama/epidemiologia, neoplasias da mama/tratamento farmacológico, qualidade de vida, saúde da mulher

Resumo

Introdução: O câncer de mama pode acometer diferentes perfis de mulheres ao redor do mundo. Além disso, a quimioterapia para tratar neoplasias mamárias afeta diretamente a qualidade de vida relacionada à saúde. Objetivo: Descrever o perfil clínico-epidemiológico e comparar a qualidade de vida relacionada à saúde geral e específica de mulheres com câncer de mama durante a quimioterapia. Método: Estudo observacional e prospectivo com 140 mulheres com câncer de mama no Nordeste do Brasil avaliadas no ciclo intermediário e ao final da quimioterapia. A qualidade de vida foi avaliada por um instrumento geral (EORTC-QLQ-C30) e um módulo específico (EORTC-QLQ-BR23). Os dados foram comparados com teste não paramétrico pareado, com nível de significância de 5%. Resultados: Em relação ao perfil clínico-epidemiológico, a mediana da idade foi de 50 anos, 82,9% eram pretas ou pardas e 95% moravam em Sergipe, Brasil. Além disso, 50,7% não possuíam ocupação, a mediana da renda familiar foi de um salário-mínimo, bem como a mediana da escolaridade foi de oito anos de estudo, e somente 40,7% tinham ensino médio completo. Considerando os dados dos questionários C30 e BR23, observou-se que a maior parte dos itens e escalas piorou ao final da quimioterapia quando comparados ao ciclo intermediário. Entre os itens e escalas com diferenças significativas, a maioria apresentou tamanho de efeito moderado ou alto. Conclusão: É possível concluir que o perfil clínico-epidemiológico foi desfavorável, e a quimioterapia reduziu diversos aspectos da qualidade de vida relacionada à saúde de mulheres com câncer de mama.

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Referências

Akram M, Iqbal M, Daniyal M, et al. Awareness and current knowledge of breast cancer. Biol Res. 2017;50(1):33. doi: https://doi.org/10.1186/s40659-017-0140-9

Figueiredo FWDS, Adami F. Income inequality and mortality owing to breast cancer: evidence from Brazil. Clin Breast Cancer. 2018;18(4):e651-e658. doi: https://doi.org/10.1016/j.clbc.2017.11.005

Nascimento JHF, Vieira ATS, Souza-Filho BM, et al. Breast cancer in Brazil: screening program and surgical approach. Cancer Epidemiol. 2021;73:101970. doi: https://doi.org/10.1016/j.canep.2021.101970

Dreyer MS, Nattinger AB, McGinley EL, et al. Socioeconomic status and breast cancer treatment. Breast Cancer Res Treat. 2018;167(1):1-8. doi: https://doi.org/10.1007/s10549-017-4490-3

Coughlin SS. Epidemiology of breast cancer in women. Adv Exp Med Biol. 2019;1152:9-29. doi: https://doi.org/10.1007/978-3-030-20301-6_2

Coughlin SS. Social determinants of breast cancer risk, stage, and survival. Breast Cancer Res Treat. 2019;177(3):537-48. doi: https://doi.org/10.1007/s10549-019-05340-7

Bodai BI, Tuso P. Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations. Perm J. 2015;19(2):48-79. doi: https://doi.org/10.7812/tpp/14-241

Youn HJ, Han W. A review of the epidemiology of breast cancer in Asia: focus on risk factors. Asian Pac J Cancer Prev. 2020;21(4):867-80. doi: https://doi.org/10.31557/apjcp.2020.21.4.867

Bigoni A, Ferreira Antunes JL, Weiderpass E, et al. Describing mortality trends for major cancer sites in 133 intermediate regions of Brazil and an ecological study of its causes. BMC Cancer. 2019;19(1):940. doi: https://doi.org/10.1186/s12885-019-6184-1

Silva MJS, O'Dwyer G, Osorio-de-Castro CGS. Cancer care in Brazil: structure and geographical distribution. BMC Cancer. 2019;19(1):987. doi: https://doi.org/10.1186/s12885-019-6190-3

Camargo JDAS, Dos Santos J, Simões TC, et al. Mortality due to breast cancer in a region of high socioeconomic vulnerability in Brazil: analysis of the effect of age-period and cohort. PLoS One. 2021;16(8):e0255935. doi: https://doi.org/10.1371/journal.pone.0255935

Livshits Z, Rao RB, Smith SW. An approach to chemotherapy-associated toxicity. Emerg Med Clin North Am. 2014;32(1):167-203. doi: https://doi.org/10.1016/j.emc.2013.09.002

Fisusi FA, Akala EO. Drug combinations in breast cancer therapy. Pharm Nanotechnol. 2019;7(1):3-23. doi: https://doi.org/10.2174/2211738507666190122111224

Mokhtari-Hessari P, Montazeri A. Health-related quality of life in breast cancer patients: review of reviews from 2008 to 2018. Health Qual Life Outcomes. 2020;18(1):338. doi: https://doi.org/10.1186/s12955-020-01591-x

Villar RR, Fernández SP, Garea CC, et al. Quality of life and anxiety in women with breast cancer before and after treatment. Rev Lat Am Enfermagem. 2017;25:e2958. doi: https://doi.org/10.1590/1518-8345.2258.2958

Lopes JV, Bergerot CD, Barbosa LR, et al. Impact of breast cancer and quality of life of women survivors. Rev Bras Enferm. 2018;71(6):2916-21. doi: https://doi.org/10.1590/0034-7167-2018-0081

Carmona-Bayonas A, Calderón C, Hernández R, et al. Prediction of quality of life in early breast cancer upon completion of adjuvant chemotherapy. NPJ Breast Cancer. 2021;7(1):92. doi: https://doi.org/10.1038/s41523-021-00296-8

Malta M, Cardoso LO, Bastos FI, et al. STROBE initiative: guidelines on reporting observational studies. Rev Saude Publica. 2010;44(3):559-65. doi: https://doi.org/10.1590/S0034-89102010000300021

Barone BB, Yeh HC, Snyder CF, et al. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA. 2008;300(23):2754-64. doi: https://doi.org/10.1001/jama.2008.824

Peairs KS, Barone BB, Snyder CF, et al. Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J Clin Oncol. 2011;29(1):40-6. doi: https://doi.org/10.1200/jco.2009.27.3011

Instituto Nacional de Câncer José Gomes Alencar. Estimativa 2016: incidência de Câncer no Brasil. Rio de Janeiro: INCA; 2015.

Michels FAS, Latorre MRDO, Maciel MS. Validity, reliability and understanding of the EORTC-C30 and EORTC-BR23, quality of life questionnaires specific for breast cancer. Rev Bras Epidemiol. 2013;16(2):352-63. doi: https://doi.org/10.1590/s1415-790x2013000200011

Osoba D, Rodrigues G, Myles J, et al. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol. 1998;16(1):139-44. doi: https://doi.org/10.1200/jco.1998.16.1.139

Goodwin PJ, Ambrosone CB, Hong CC. Modifiable lifestyle factors and breast cancer outcomes: current controversies and research recommendations. Adv Exp Med Biol. 2015;862:177-92. doi: https://doi.org/10.1007/978-3-319-16366-6_12

Rojas K, Stuckey A. Breast cancer epidemiology and risk factors. Clin Obstet Gynecol. 2016;59(4):651-72. doi: https://doi.org/10.1097/grf.0000000000000239

Jerônimo AFA, Freitas AGQ, Weller M. Risk factors of breast cancer and knowledge about the disease: an integrative revision of Latin American studies. Cien Saude Colet. 2017;22(1):135-49. doi: https://doi.org/10.1590/1413-81232017221.09272015

Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-76. doi: https://doi.org/10.1093/jnci/85.5.365

Lantz PM, Mujahid M, Schwartz K, et al. The influence of race, ethnicity, and individual socioeconomic factors on breast cancer stage at diagnosis. Am J Public Health. 2006;96(12):2173-8. doi: https://doi.org/10.2105/ajph.2005.072132

Silber JH, Rosenbaum PR, Ross RN, et al. Disparities in breast cancer survival by socioeconomic status despite medicare and medicaid insurance. Milbank Q. 2018;96(4):706-54. doi: https://doi.org/10.1111/1468-0009.12355

Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, et al. Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017;67(5):378-97. doi: https://doi.org/10.3322/caac.21405

Spei ME, Samoli E, Bravi F, et al. Physical activity in breast cancer survivors: a systematic review and meta-analysis on overall and breast cancer survival. Breast. 2019;44:144-52. doi: https://doi.org/10.1016/j.breast.2019.02.001

Kameo SY, Barbosa-Lima R, Ramos MJO, et al. Clinical-epidemiological profile of women undergoing oncological treatment for invasive ductal breast carcinoma. Res Soc Dev. 2021;10(1):e39110111836. doi: https://doi.org/10.33448/rsd-v10i1.11836

Johansson I, Killander F, Linderholm B, et al. Molecular profiling of male breast cancer - lost in translation? Int J Biochem Cell Biol. 2014;53:526-35. doi: https://doi.org/10.1016/j.biocel.2014.05.007

Meng R, Venugopal K, Thomas H, et al. Cancer staging at diagnosis data comparisons in South Australia. Sci Rep. 2020;10:1008. doi: https://doi.org/10.1038/s41598-020-57704-5

Marinho PML, Barbosa-Lima R, Santos JCO, et al. Chemotherapy-related oral mucositis in breast cancer patients: a brief review. Res Soc Dev. 2021;10(3):e25610313338. doi: https://doi.org/10.33448/rsd-v10i3.13338

Mackey JR, Pieńkowski T, Crown J, et al. Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer: BCIRG-005 randomized trial. Ann Oncol. 2016;27(6):1041-47. doi: https://doi.org/10.1093/annonc/mdw098

Jacob SA, Do V, Wilson BE, et al. The value of first-line chemotherapy and targeted therapy in the treatment of breast cancer. Eur J Cancer Care (Engl). 2021;30(1):e13352. doi: https://doi.org/10.1111/ecc.13352

Binotto M, Reinert T, Werutsky G, et al. Health-related quality of life before and during chemotherapy in patients with early-stage breast cancer. Ecancermedicalscience. 2020;14:1007. doi: https://doi.org/10.3332/ecancer.2020.1007

Coelho RCFP, Garcia SN, Marcondes L, et al. Impact on the quality of life of women with breast cancer undergoing chemotherapy in public and private care. Invest Educ Enferm. 2018;36(1):e04. doi: https://doi.org/10.17533/udea.iee.v36n1e04

Garcia SN, Jacowski M, Castro GC, et al. Quality of life domains affected in women with breast cancer. Rev Gaucha Enferm. 2015;36(2):89-96. doi: https://doi.org/10.1590/1983-1447.2015.02.45718

Publicado

2022-12-12

Como Citar

1.
Marinho PML, Lima RB, Santos JC de O, Santos DK da C, Silva GM, Kameo SY, Sawada NO. Perfil Clínico-Epidemiológico e Qualidade de Vida Relacionada à Saúde de Mulheres com Câncer de Mama durante Tratamento Quimioterápico: Estudo Observacional. Rev. Bras. Cancerol. [Internet]. 12º de dezembro de 2022 [citado 3º de julho de 2024];68(4):e-253164. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/3164

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