Breast Granular Cell Tumor Presenting as a BI-RADS 5 Nodule on Ultrasonography: Case Report
DOI:
https://doi.org/10.32635/2176-9745.RBC.2024v70n2.4609Keywords:
Breast Neoplasms/epidemiology, Granular Cell Tumor/epidemiology, Pathology, Women’s HealthAbstract
Introduction: Granular cell tumor (GCT) is a rare and predominantly benign neoplasm that can be found in various parts of the body, frequently found in the neck and head region. It typically occurs in adults aged 40 to 60 years, with a higher incidence in females. Granular Cell Tumor of the breast represents 5% to 15% of all GCTs, and due to clinical and radiological characteristics that may resemble breast malignancies, histopathological diagnosis is essential. It typically manifests as a solitary, palpable mass, although multicentricity is possible in up to 20% of cases, whether in breast tumors or other sites. Case report: 43-year-old patient with a hypoechoic nodule classified as BI-RADS 5 on ultrasound, located in the superolateral quadrant of the left breast, at 2 o’clock, with an irregular shape, measuring 7.0 x 6.0 mm in the longest axis and 50 mm from the papilla. As it was radiologically suspicious, a breast core biopsy was performed, which microscopically was categorized as a lesion of uncertain malignancy potential. Immunohistochemical analysis revealed positivity for S100 and CD68, indicating Schwann cell origin, associated with negativity for cytokeratins and hormone receptors, disfavoring the epithelial origin of the carcinomas. The therapeutic approach was complete surgical excision of the nodule, and histopathological analysis confirmed it was GCT. Conclusion: Reporting this case is important due to its rarity and potential to mimic breast cancers.
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